Beklazon Eco - instructions for use, analogs, reviews and release forms (aerosol for inhalation of 50 mcg, 100 mcg and 250 mcg Easy breathing) of a drug for the treatment of bronchial asthma in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Beklazon Eco. Comments of visitors of the site - consumers of this medicine, as well as opinions of doctors of experts on the use of Beclason Eco in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Beckzon Eco in the presence of existing structural analogues.Use for the treatment of bronchial asthma and allergic rhinitis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Beklazon Eco - Glucocorticosteroid (GCS) for inhalation. Has anti-inflammatory and anti-allergic effect.

It inhibits the release of inflammatory mediators, increases the production of lipomodulin, an inhibitor of phospholipase A, reduces the release of arachidonic acid, inhibits the synthesis of prostaglandins. It prevents the accumulation of neutrophils, reducing the formation of inflammatory exudates and production of lymphokines, inhibits the migration of macrophages, which leads to a slowing of the processes of infiltration and granulation.

Increases the number of active beta-adrenergic receptors, neutralizes their desensitization, restores patient's reaction to bronchodilators, allowing to reduce the frequency of their use.

Under the action of beclomethasone, the number of mast cells in the mucous membrane of the bronchi decreases, the epithelial edema decreases and the mucus secretion by the bronchial glands. It causes relaxation of the smooth muscles of the bronchi, reduces their hyperreactivity and improves the function of external respiration.

Does not have mineralocorticoid activity.

In therapeutic doses does not cause side effects, characteristic of systemic GCS.

With intranasal application, it eliminates edema, hyperemia of the nasal mucosa.

The therapeutic effect usually develops after 5-7 days of course use of beclomethasone.

With external and local application has anti-allergic and anti-inflammatory effect.

Composition

Beclomethasone dipropionate + auxiliary substances.

Pharmacokinetics

After inhalation, up to 56% of the dose of the drug settles in the lower respiratory tract; The remaining amount settles in the mouth, pharynx and is swallowed. In the lungs, before absorption of beclomethasone, dipropionate is extensively metabolized to the active metabolite B-17-MP. Systemic absorption of B-17-MP occurs in the lungs (36% of the pulmonary fraction), in the gastrointestinal tract (26% of the dose received when the dose is ingested). The absolute bioavailability of unchanged beclomethasone dipropionate and B-17-MP is approximately 2% and 62% of the inhalation dose, respectively. Beclomethasone dipropionate is rapidly absorbed. The B-17-MP is absorbed more slowly. There is an approximately linear relationship between the dose increase and the system exposure of the drug. Binding to plasma proteins is relatively high - 87%.Output is up to 64% with feces and up to 14% in urine for 96 h mainly in the form of free and conjugated metabolites.

Indications

• for inhalation application: treatment of bronchial asthma (including with insufficient effectiveness of bronchodilators and / or cromoglycate sodium, as well as hormone-dependent bronchial asthma of severe course in adults and children);
• for intranasal use: prevention and treatment of year-round and seasonal allergic rhinitis, including hay fever rhinitis, vasomotor rhinitis;
• for external and topical application: in combination with antimicrobial agents - infectious and inflammatory diseases of the skin and ear.

Forms of release

Aerosol for inhalation dosed with 50 μg (Beclason Eco).

Aerosol for inhalation dosed, activated by inhalation 50 μg, 100 μg and 250 μg (Beclason Eco Light Breathing).

Instructions for use and dosing regimen

Aerosol Beclason Eco

When inhaled, the average dose for adults is 400 mcg per day, the frequency of application is 2-4 times a day. If necessary, the dose may be increased to 1 g per day. For children, a single dose of 50-100 μg, the frequency of application - 2-4 times a day.

With intranasal administration, the dose is 400 μg per day, the frequency of application is 1-4 times a day.

For external and local administration, the dose depends on the indications and the drug dosage form used.

Aerosol Beclason Eco Light Breath

Beklazone Eco Light Breath is only for inhalation.

Beklazone Eko Easy Breathing is used regularly (even in the absence of symptoms of the disease), the dose of beclomethasone dipropionate is selected taking into account the clinical effect in each specific case.

With an easy course of bronchial asthma, the volume of forced expiration (FEV1) or peak expiratory flow (PSV) is more than 80% of the required values ​​with a PSV of less than 20%.

In the medium-heavy course of FEV1 or PSV is 60-80% of the required values, the daily spread of PSV indicators is 20-30%.

In severe FEV1 or PSV, 60% of the required values, the daily spread of PSV indicators is more than 30%.

When switching to a high dose of inhaled beclomethasone dipropionate, many patients receiving systemic GCS can reduce their dose or cancel them altogether.

Initial dose of Beklazone Eco Light Breath is determined by the severity of bronchial asthma. The daily dose is divided into several doses.

Depending on the individual response of the patient, the dose of the drug can be increased to the appearance of a clinical effect or reduced to the minimum effective dose.

Adults and children 12 years of age and older, the recommended initial doses of the drug for bronchial asthma of the lung current are 200-600 μg per day; at a bronchial asthma of an average course - 600-1000 mkg a day; at a bronchial asthma of a heavy current - 1000-2000 mkg a day.

Children aged 4 to 12 years, the dose of the drug is up to 400 micrograms per day in several receptions.

There is no need to adjust the dose of Beklazone Eco Light Breathing in the elderly, in patients with renal or hepatic insufficiency.

If you miss an inhalation accidentally, the next dose should be taken at the appropriate time in accordance with the treatment regimen.

Beklazone Eco Light Breath with a dose of 250 μg of beclomethasone is not intended for pediatric use.

Instructions for use of the inhaler

While holding the inhaler in the vertical position, open the lid. Make a deep exhalation. Tightly grasp the mouthpiece with your lips. Make sure that the hand does not block the ventilation holes on the top of the inhaler, and the inhaler is in an upright position. Make a slow maximum breath through the mouthpiece.Hold your breath for 10 seconds or as long as possible. Then the inhaler should be removed from the oral cavity and exhaled slowly. After use, keep the inhaler in an upright position. Close the cover. If more than one inhalation is necessary, close the lid, wait at least 1 minute, and then repeat the inhalation process.

Cleaning the inhaler

Remove the upper part of the inhaler. Remove the metal can. Rinse the bottom of the inhaler in warm water and dry. Insert the can into place. Close the cover and screw the upper part of the inhaler to its housing. Do not wash the top of the inhaler. If the inhaler does not work properly, unscrew its upper part and manually press the can.

Side effect

• hoarseness;
• feeling of irritation in the throat;
• sneeze;
• cough;
• eosinophilic pneumonia;
• paradoxical bronchospasm;
• with intranasal application - perforation of the nasal septum;
• candidiasis of the oral cavity and upper respiratory tract, especially with prolonged use, taking place with local antifungal therapy without discontinuing treatment;
• rash;
• hives;
• itching;
• erythema and swelling of the eyes, face, lips and throat;
• decreased function of the adrenal cortex;
• osteoporosis;
• cataract;
• glaucoma;
• stunted growth in children.

Contraindications

• severe attacks of bronchial asthma requiring intensive care;
• tuberculosis;
• Candidomycosis of the upper respiratory tract;
• 1 trimester of pregnancy;
• hypersensitivity to beclomethasone.

Application in pregnancy and lactation

Contraindicated in the 1st trimester of pregnancy.

The use in 2 and 3 trimesters of pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus. Newborns, whose mothers received Beclason Eco in pregnancy, should be carefully screened for the lack of adrenal function.

If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.

Use in children

Beklazon Eco

Preparations for inhalation use, containing 1 dose of 250 μg beclomethasone, are not intended for children under 12 years of age. When inhaled for children, a single dose of 50-100 μg, the frequency of application - 2-4 times a day.

Beklazone Eco Light Breath

Contraindicated in children under 4 years. Children aged 4 to 12 years, the dose of the drug is up to 400 micrograms per day in several receptions.

special instructions

Beklazone Eco is not intended for relief of acute asthmatic attacks. It should also not be used in severe asthma attacks requiring intensive care. The recommended route of administration for the dosage form to be used should be strictly observed.

With special care and under close supervision of the doctor, beclomethasone should be used in patients with adrenal insufficiency.

The transfer of patients permanently taking GCS inside, on inhalation forms can be performed only in a stable state.

In the case of the possibility of developing paradoxical bronchospasm for 10-15 minutes before the administration of Beclason, Eco is administered inhalation of bronchodilators (eg, salbutamol).

With the development of candidiasis of the oral cavity and upper respiratory tract, local antifungal therapy is indicated without discontinuing beclomethasone treatment. Infectious and inflammatory diseases of the nasal cavity and paranasal sinuses in the appointment of appropriate therapy are not a contraindication for treatment with beclomethasone.

It is not recommended to abruptly cancel the drug Beklazone Eco Light Breath.

It is necessary to protect eyes from getting the drug. By washing after inhalation, it is possible to prevent damage to the skin of the eyelids and nose.

Balloon with Beclazone Eco Light Breathing can not be pierced, disassembled or thrown into the fire, even if it is empty. Like most other inhalation agents in aerosol packs, Beclason Eco Light Breathing can be less effective at low temperatures. When cooling the can, it is recommended to remove it from the plastic case and warm it with your hands for several minutes.

Drug Interactions

With the simultaneous use of beclomethasone with other GCS for systemic or intranasal use, it is possible to enhance the suppression of adrenal cortex function. The previous inhalation use of beta-adrenostimulants may increase the clinical efficacy of beclomethasone.

Analogs of the drug Beklazon Eco

Structural analogs for the active substance:

• Aldecin;
• Beklazone;
• Beklazone Easy Breath;
• Beklazone Eco Light Breath;
• Behlat;
• Beclodget 250;
• Beclomet Ishihiler;
• Beclomethasone;
• Beclomethasone dipropionate;
• Beclospir;
• Becloforte;
• Baconase;
• Bechotide;
• Clenil;
• Nasobek;
• Plibékot;
• Rinocyclenyl.

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