Nalgezin - instructions for use, analogs, reviews and release forms (tablets 275 mg, 550 mg Forte) of the drug for the treatment of migraine, radiculitis, lumbulia, headache and dental pain in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Nalgezin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Nalgezin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Nalgezin in the presence of existing structural analogues. Use to treat pain with migraine, radiculitis, lumbulgia, headache and dental in adults, children, as well as during pregnancy and lactation.Composition and interaction of anesthetic drug with alcohol.

Nalgezin non-steroidal anti-inflammatory drug (NSAID). Possesses analgesic, antipyretic and anti-inflammatory action. The mechanism of action is associated with a non-selective inhibition of cyclooxygenase 1 and 2 (COX-1, COX-2) activity.

The tablets, covered with a film membrane, dissolve well, are quickly absorbed from the digestive tract and provide a rapid onset of the analgesic effect.

Composition

Naproxen sodium + auxiliary substances.

Pharmacokinetics

Absorption from the gastrointestinal tract - fast and complete, bioavailability - 95% (the intake of food practically does not affect either the completeness or the rate of absorption). The connection with plasma proteins is more than 99%. Css is determined after 4-5 doses in a single dose (ie on 2-3 days of taking the drug). Metabolized in the liver to dimethylnaproxen with the participation of the enzyme system CYP2C9. 98% of the dose is excreted in the urine, 10% of them are excreted unchanged; with bile is excreted 0.5-2.5%. With renal failure, metabolites can be accumulated.

Indications

• diseases of the musculoskeletal system (rheumatoid arthritis, psoriatic arthritis, juvenile chronic arthritis,ankylosing spondylitis (Bekhterev's disease); gouty arthritis, rheumatic soft tissue, osteoarthritis of peripheral joints and spine, including with a radicular syndrome, tendovaginitis, bursitis);
• pain mild or moderate severity: neuralgia, ossaliya, myalgia, sciatica, post-traumatic pain syndrome (tensile and bruises), accompanied by inflammation, postoperative pain (in traumatology, orthopedics, gynecology, maxillofacial surgery), headache, migraine, tuberculosis, adnexitis, toothache;
• in the complex therapy of infectious and inflammatory diseases of the ear, throat, nose with severe pain syndrome (pharyngitis, tonsillitis, otitis);
• febrile syndrome with "colds" and infectious diseases. Nalgezin is used for symptomatic therapy (to reduce pain, inflammation and decrease in elevated body temperature) and does not affect the progression of the underlying disease.

Forms of release

Tablets coated with a coating of 275 mg.

The tablets covered with a cover of 550 mg (Nalgezin Forte).

Other dosage forms, whether it be ointment, cream or capsules, do not exist.

Instructions for use and dosing regimen

Tablets should be taken with a sufficient amount of water.

When using the drug as an analgesic, the average daily dose is 2-4 tablets (550-1100 mg).

With very severe pain and no history of gastrointestinal diseases, a doctor can increase the daily dose to 6 tablets (1650 mg), but not more than 2 weeks.

When using the drug as an antipyretic agent, the initial dose is 2 Nalgesine tablets, then one tablet (275 mg) every 6-8 hours should be taken.

To prevent migraine attacks, 2 tablets (550 mg) are recommended 2 times a day. However, treatment should be discontinued if the frequency, intensity and duration of migraine attacks do not decrease within 4-6 weeks.

At the first signs of a migraine attack, you should take 3 tablets (825 mg), and if necessary 1-2 tablets (275-550 mg) after 30 minutes.

For the relief of menstrual pains and spasms, pain after injection of IUD (intrauterine spiral) and other gynecological pains, the drug is prescribed in an initial dose of 2 tablets (550 mg), then - 1 tablet (275 mg) every 6-8 hours.

In case of an acute attack of gout, the initial dose is 3 tablets (825 mg), then 2 tablets (550 mg) after 8 hours, and then 1 tablet (275 mg) every 8 hours until the seizure stops.

In rheumatoid diseases (rheumatoid arthritis, osteoarthritis and ankylosing spondylitis), the average initial dose of the drug is 2-4 tablets (550-1100 mg) 2 times a day in the morning and in the evening. The initial daily dose, ranging from 3 (825 mg) to 6 tablets (1,650 mg) is recommended for patients with severe night pain and / or severe morning stiffness, patients switched to treatment with Naproxen sodium from other NSAIDs in high doses, and patients whose pain is the leading symptom.

The average daily dose is 2-4 tablets (550-1100 mg), administered in 2 divided doses. Morning and evening doses may not be the same. After consultation with the attending physician, you can change them depending on the prevalence of symptoms, i.e. night pain and / or morning stiffness.

Children older than 9 years and / or with a body weight of more than 27 kg the drug is prescribed in a daily dose of 10 mg / kg in 2 divided doses.

Side effect

Side effects are most often noted with the use of high doses of Nalgezin:

• constipation, diarrhea;
• abdominal pain;
• dyspepsia;
• nausea;
• ulcerative stomatitis;
• erosive and ulcerative lesions and bleeding from the gastrointestinal tract;
• abnormal liver function;
• jaundice;
• bloody vomiting;
• melena;
• hearing loss;
• dizziness;
• headache;
• drowsiness;
• depression;
• sleep disorders;
• violation of concentration of attention;
• insomnia;
• malaise;
• slowing the reaction rate;
• aseptic meningitis;
• itching;
• increased sweating;
• alopecia;
• photodermatosis;
• noise in ears;
• impaired vision;
• hearing impairment;
• swelling;
• dyspnea;
• palpitation;
• congestive heart failure;
• vasculitis;
• glomerulonephritis;
• hematuria;
• interstitial nephritis;
• nephrotic syndrome;
• kidney failure;
• renal papillary necrosis;
• menstrual cycle disorders;
• eosinophilia, granulocytopenia, leukopenia, thrombocytopenia, aplastic anemia, hemolytic anemia;
• eosinophilic pneumonitis;
• skin rash;
• hives;
• angioedema;
• epidermal necrolysis;
• erythema multiforme;
• Stevens-Johnson syndrome;
• thirst;
• hyperthermia;
• hyperglycemia;
• hypoglycemia;
• prolongation of bleeding time.

Contraindications

• period after aortocoronary shunting;
• erosive and ulcerative lesions of the stomach or duodenum, active gastrointestinal bleeding;
• inflammatory bowel disease in the phase of exacerbation (NNC, Crohn's disease);
• cerebrovascular bleeding or other bleeding and hemostasis disorders;
• severe hepatic impairment or active liver disease;
• expressed renal failure (CC less than 20 ml / min), incl. confirmed hyperkalemia, progressive kidney disease;
• oppression of bone marrow hematopoiesis;
• pregnancy;
• the period of breastfeeding;
• anamnestic data on the attack of bronchospasm, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs (complete or incomplete acetylsalicylic acid intolerance syndrome - rhinosinusitis, urticaria, polyps of the nasal mucosa, asthma);
• hypersensitivity to naproxen or naproxen sodium.

Application in pregnancy and lactation

It is not recommended to appoint Nalgezin and Nalgezin Forte during pregnancy and lactation (breastfeeding).

Use in children

Contraindicated in children under 9 years old (Nalgezin), at the age of 15 years (Nalgezin Forte).

In children aged 9 to 12 years, the drug Nalgesin is used only as prescribed by the doctor.

Application in elderly patients

Elderly people (over 65 years of age) are prescribed no more than 2 tablets per day.

special instructions

To reduce the risk of developing adverse events on the part of the gastrointestinal tract, a minimum effective dose should be used with the minimum possible short course.

If pain and fever persists or becomes worse, you should consult your doctor.

With caution should prescribe the drug in IHD, cerebrovascular diseases, congestive heart failure, dyslipidemia / hyperlipidemia, diabetes, peripheral artery disease, smoking, CC less than 60 ml / min, anamnestic data on the development of gastric ulcer, the presence of Helicobacter pylori (Helicobacter) infection, , long-term use of NSAIDs, frequent use of alcohol (possibly the development of erosions, gastrointestinal ulcers and bleeding), severe somatic diseases, elderly patients, concomitant therapy uyuschimi drugs: anticoagulant (e.g., warfarin), antiplatelet agents (e.g.,acetylsalicylic acid, clopidogrel), oral steroids (corticosteroids) (e.g., prednisolone), selective serotonin reuptake inhibitor (such as citalopram, fluoxetine, paroxetine, sertraline).

With caution and only after consultation with your doctor should take the drug to patients with bronchial asthma, with bleeding disorders, as well as in patients with hypersensitivity to other analgesics.

Caution should be given to patients with liver disease and kidney failure. In patients with renal insufficiency, it is necessary to control the clearance of creatinine. When QC is below 20 ml / min, naproxen is not recommended. In chronic alcoholic and other forms of cirrhosis, the concentration of unbound naproxen increases, so such patients are recommended to take the drug at lower doses.

Older patients are also recommended to administer the drug at lower doses.

Nalgezin should not be taken with other anti-inflammatory drugs and analgesics, except for doctor's prescriptions.

You should avoid taking naproxen for 48 hours before surgery.

If it is necessary to determine 17-corticosteroids, the drug should be discontinued 48 hours before the study. Similarly, naproxen may affect the determination of 5-hydroxyindoleacetic acid in the urine.

Each Nalgezin tablet contains approximately 25 mg of sodium. This should be taken into account when observing a diet with a restriction of salt intake.

Impact on the ability to drive vehicles and manage mechanisms

Naproxen slows the reaction rate in patients. This should be taken into account when driving a car and performing tasks that require special attention.

Drug Interactions

In the treatment of anticoagulants should be borne in mind that naproxen can increase the time of bleeding.

Do not use the drug simultaneously with other NSAIDs (increased risk of side effects).

Patients who simultaneously receive hydantoins, anticoagulants, or other medications that bind to a large extent with plasma proteins should monitor signs of potentiation of the action or overdose of these drugs.

The drug Nalgezin can reduce the antihypertensive effect of Propranolol and other beta-blockers,and may also increase the risk of renal failure associated with the use of ACE inhibitors.

Under the action of naproxenum, natriuretic action of Furosemide is inhibited.

Inhibition of renal clearance of lithium leads to an increase in the concentration of lithium in plasma.

The use of probenecid increases the level of naproxen in plasma.

Cyclosporine with simultaneous application with naproxen increases the risk of developing kidney failure.

Naproxen slows the excretion of methotrexate, phenytoin, sulfonamides, increasing the risk of developing their toxic effects.

Antacid preparations containing magnesium and aluminum reduce the absorption of naproxen.

Analogues of Nalhezin

Structural analogs for the active substance:

• Ultrazir Ultra;
• Aliv;
• Apranaks;
• Nalgezin forte;
• Naprios;
• Naprobeene;
• Naproxen;
• Naproxen sodium;
• Pronaxen;
• Sanaprox.

Similar medicines:

Other medicines: