Fermatron - instructions for use, analogs, reviews and release forms (injections in ampoules for intra-articular injection of a synovial fluid prosthesis) drugs for the treatment of arthrosis and joint stiffness in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Fermatron. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Fermatron in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Fermatron in the presence of existing structural analogs.Use for the treatment of arthrosis and stiffness of joints, including after injuries in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Fermatron - viscoelastic drug, used as an injection in the synovial space of the joints with osteoarthritis. It is a 1% solution of hyaluronate (sodium hyaluronate, sodium salt of hyaluronic acid). Fermatron is an analogue (prosthesis) of the human synovial fluid. Replaces the synovial hyaluronate, damaged by degenerative or traumatic changes in the joint.
The action of Fermatron is due to biocompatibility and physico-chemical properties. The fermatron contains the equivalent of natural human hyaluronate, a high molecular weight polysaccharide consisting of repeated disaccharide residues of N-acetylglucosamine and glucuronic acid, which is a component of synovial fluid of the joints. It is synthesized by fermentation of Streptococcus equi and thoroughly purified. Hyaluronate performs the functions of a shock absorber with direct loads on the joint and lubricant (lubricant) under lateral loads.Stimulates cells of synovia, carries out the function of a filter, which detains cells and molecules that damage cartilage.
Fermatron affects the cause of progression of arthrosis. It restores the visco-elastic and protective properties of the joint fluid, reduces inflammatory reactions in the joint, protects the articular cartilage, restores the homeostasis in the cartilage, stimulates the synthesis of its own hyaluronate (hyaluronic acid). Eliminates pain and stiffness of the knee and other large synovial joints.
A clinically valid result is achieved after the 4th injection of Fermatron; The therapeutic effect persists for up to 6 months or more after the last injection.
The fermatron is ready-to-use - in a sterile syringe for single use with a special protective rubber cap and thread for tight connection with the injection needle clutch, which eliminates the leakage of the drug at the time of insertion into the joint cavity. Due to the form of release (ready-made syringe), the possibility of introducing a secondary infection with intra-articular injection is minimized.
In clinical studies, the absence of toxic, allergic and mutagenic properties was shown in Fermatron.
Composition
Sodium hyaluronate in phosphate buffer + auxiliary substances.
Indications
- relief of pain syndrome and stiffness in the knee and other joints with degenerative and traumatic changes in them (at any stage of osteoarthritis and after arthroscopic interventions).
Forms of release
Solution in a syringe for a single intraarticular injection of a synovial fluid prosthesis 2 ml (blister or ampoule with a syringe).
Instructions for use and how to use them
The mode of administration of Fermatron depends on the severity of degenerative or traumatic changes in the joint and is determined by the physician individually.
The contents of the syringe are sterile and must be injected with a sterile needle of the appropriate size (19 to 20). The syringe is disposable, has a cannula Luer. After use, the syringe and needle should be disposed of.
The fermatron is introduced into the synovial space of the affected joint (intra-articular) with an interval of 7 days (1 time per week). Intra-articular injections are performed by the doctor on an outpatient basis. Before the introduction of Fermatron, the skin should be treated at the site of injection with an antiseptic and wait until it dries completely.In the presence of exudate in the joint cavity, it should be removed before the introduction of Fermatron. The recommended single dose of Fermatron for large joints is 2 ml (20 mg). To achieve a stable effect, usually 4 injections with a break of 1 week, although clinical trials show a good effect after the 3rd injection. It is recommended not more than 5 injections of Fermatron per course.
The duration of the therapeutic effect in patients with moderate and moderate degree of osteoarthritis persists to 6 or more months.
Side effect
- redness, local secondary pain, sensation of heat in the joint, swelling of the joint bag. These side effects are quickly removed by applying a cold on the joint for a short time (5-10 minutes);
- intra-articular exudation (usually minor);
- allergic reactions (registered in a very small number of cases).
As a rule, all the symptoms pass independently a few days after the introduction.
Contraindications
- hypersensitivity to the active substance Fermatron - sodium hyaluronate;
- presence of abrasions, non-healing or infected wounds in the joint region;
- severe infection or inflammation of the joint;
- lymphatic, venous stasis on the side of the damaged joint;
- pregnancy and lactation;
- age to 18 years.
With the development of synovitis, it is not recommended to use Fermatron to stop inflammation, since the drug is diluted with synovial fluid, and the therapeutic effect is reduced.
When carrying out the course of treatment with the drug, it is necessary to exclude the introduction into the cavity of the synovial joint of the anesthetic and other pharmacological agents.
Patients with inflammatory diseases, in particular, with Bechterew's disease and rheumatoid arthritis, Fermatron is not prescribed.
Application in pregnancy and lactation
There is no data on the safety of Fermatron in pregnancy and lactation. Use the drug in pregnancy and lactation is not recommended.
Use in children
Children are not used.
special instructions
It is not recommended to use Fermatron with significant intra-articular effusion in the patient.
During injections, nurses should follow all the precautions that rely on intra-articular injections. The skin at the site of the injection must be treated, but preparations containing quaternary ammonium salts are excluded.The sodium hyaluronate solution is warmed to room temperature before the operation.
Extrararticular (periarticular) administration of Fermatron in the capsule or joint synovial tissues is not allowed. This can cause local side effects. It is inadmissible to get the substance into the blood.
After the administration of the drug, the patient should adhere to a sparing regimen for the first few days and refrain from loading the joint.
Sodium hyaluronate is synthesized by fermentation of Streptococcus equi and thoroughly purified. However, physicians should consider the immunological and potential risks that may be associated with the injection of any biological material.
Store at a temperature of 2-8 degrees Celsius. Freezing the medicine is unacceptable.
Drug Interactions
Medical data on the incompatibility of sodium hyaluronate with other drugs for intra-articular use are not available (co-administration is not recommended). Compatibility with anti-inflammatory and analgesic drugs is confirmed.
Analogues of the drug Fermatron
Structural analogs for the active substance:
- Atri Ing;
- Hyaluron;
- Durolane;
- Ostenil;
- Ostenilmini (Ostenil mini, Miniostenil);
- Ostenil plus (Ostenil plus);
- RusVisk;
- Synvisc;
- Synocrom;
- Synocrom Forte;
- Suplazin (Suplasyn);
- Fermathron Plus;
- Fermatron S (Fermathron S).
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