Indap - instructions for use, analogs, reviews and release forms (capsules or tablets 2.5 mg) of a diuretic for the treatment of edema and pressure in adults, children and pregnancy

In this article, you can read the instructions for using the drug Indap. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Indap in their practice. A big request is to add more actively your comments about the diuretic: the medicine helped to get rid of the disease, which complications and side effects were observed, possibly not declared by the manufacturer in the annotation. Analogues of Indap if there are existing structural analogues. Use to treat edema and reduce pressure in adults, children, as well as during pregnancy and lactation.

Indap - antihypertensive drug, diuretic (diuretic).

Indapamide (active ingredient of the drug Indap) belongs to the group of noniazide sulfonamides, by pharmacological properties is similar to thiazide-like diuretics. Reduces the tone of smooth arteries musculature, reduces OPSS. Has a moderate saluretic and diuretic effect associated with the blockade of the reabsorption of sodium, chlorine, hydrogen ions and, to a lesser extent, potassium ions in the proximal tubules and the cortical segment of the distal tubules of the kidneys. The decrease in OPSS is also due to a decrease in the sensitivity of adrenoreceptors of the vascular wall to norepinephrine (noradrenaline) and angiotensin 2 by an increase in the synthesis of prostaglandins with vasodilating activity.

Indap in therapeutic doses practically does not affect lipid and carbohydrate metabolism.

Antihypertensive effect is manifested by the end of the first week and reaches a maximum 2-12 weeks after the start of the drug.

Composition

Indapamide hemihydrate + excipients.

Pharmacokinetics

After ingestion, Indap is rapidly absorbed from the digestive tract. Binding to plasma proteins is 75%.It is excreted from the body, mainly by the kidneys (about 60%), in most cases in the form of metabolites, 5% - unchanged.

Indications

• arterial hypertension;
• edema.

Forms of release

Capsules 2.5 mg (sometimes mistakenly called pills).

There are no other medicinal forms, including retarded (prolonged action) of the original drug Indap.

Instructions for use and dosing regimen

The drug is given in a dose of 2.5 mg once a day in the morning. Capsule should be swallowed whole, not liquid, squeezed with water.

Side effect

• orthostatic hypotension;
• tachycardia;
• nonspecific changes in the ST segment and U-wave on the ECG;
• nausea, vomiting;
• diarrhea;
• decreased appetite;
• dry mouth;
• pain in epigastrium;
• constipation;
• pancreatitis;
• headache;
• dizziness;
• lethargy;
• fast fatiguability;
• general weakness;
• sleep disorders;
• visual impairment;
• paresthesia;
• thrombocytopenia, leukopenia, agranulocytosis;
• aplastic anemia, hemolytic anemia;
• increased levels of uric acid, residual nitrogen and creatinine;
• skin rash;
• itching.

Contraindications

• acute disorders of cerebral circulation;
• severe liver dysfunction;
• severe renal dysfunction, anuria;
• diabetes mellitus in the stage of decompensation;
• gout;
• hypokalemia;
• pregnancy;
• lactation (breastfeeding);
• children and adolescents under 18;
• hypersensitivity to the components of the drug;
• hypersensitivity to derivatives of sulfonamides.

Application in pregnancy and lactation

Indup is contraindicated for use in pregnancy and lactation (breastfeeding).

Indapamide (like other diuretics) can cause fetoplacental ischemia and disrupt the development of the fetus.

Use in children

Contraindicated in children and adolescents under the age of 18 years.

special instructions

Safety of use and good tolerance of Indapamide make Indap a drug effective in the treatment of hypertension in patients with diabetes mild to moderate severity, chronic renal failure, hyperlipidemia.

The drug can be used as a monotherapy or in combination with other antihypertensive drugs (beta adrenoblockers, calcium channel blockers, ACE inhibitors).

With prolonged use of indapamide, the development of hypomagnesemia (magnesium release in the urine is enhanced), hypokalemia, hyponatremia, hypercalcemia and hypochloremic alkalosis. These disorders are more often observed in patients with heart failure, kidney disease, cirrhosis of the liver, diarrhea, in individuals on a salt-free diet, which necessitates the control of blood electrolytes.

When using indapamide, there may be a decrease in excretion of uric acid from the body, which leads to violations of purine metabolism and exacerbation of latent gout.

An increase in the hypotensive effect of indapamide may be observed with simultaneous use with other antihypertensive drugs that do not have a diuretic effect.

The intake of ethanol (alcohol), barbiturates, narcotic drugs, other antihypertensive drugs can provoke the development of orthostatic hypotension.

Caution should be given to indapamide therapy in patients with liver disease due to the possibility, in rare cases, of the development of metabolic alkalosis and manifestations of hepatic encephalopathy.

In connection with the primary excretion of indapamide by the kidneys, caution should be given to indap patients with impaired renal function.

Indapamide may worsen the course of SLE.

Despite the fact that indapamide has virtually no effect on carbohydrate metabolism, patients with insulin-dependent diabetes mellitus may require an increase in the dose of insulin, and with latent diabetes it is necessary to monitor blood sugar.

Drug Interactions

With the simultaneous use of indapamide with cardiac glycosides or glucocorticosteroids (GCS), the risk of developing hypokalemia increases.

With the simultaneous use of indapamide and lithium preparations, the risk of developing a toxic effect of lithium increases against the background of a decrease in its renal clearance.

Tricyclic antidepressants and antipsychotics can increase the antihypertensive effect of the drug, increase the risk of orthostatic hypotension.

Simultaneous use with ACE inhibitors increases the antihypertensive effect of Indap.

The combined use of indapamide with astemizole, Erythromycin (intravenously), sultopride,terfenadine, antiarrhythmic drugs of the 1st class (quinidine, disopyramide), amiodarone, brethylium, sotalol, non-steroidal anti-inflammatory drugs (NSAIDs) can weaken the hypotensive effect of indapamide and cause cardiac arrhythmias.

With simultaneous application with cyclosporine, an increase in the level of creatinine in the blood plasma is possible.

Indapamide increases the risk of developing kidney failure when using iodine-containing contrast agents in high doses with dehydration of the body. Before using iodine-containing contrast agents, the patient should recover the lost volume of fluid.

Analogs of the drug

Structural analogs for the active substance:

• Acrypamide;
• Acrypamide retard;
• Arindap;
• Arifon;
• Arifon retard;
• Indapamide;
• Indapamide retard;
• Inder;
• Inverse;
• Indians;
• Indyur;
• Ionik;
• Ionik retard;
• Ipres Long;
• Lauras;
• Pamid;
• Ravell;
• Retapres;
• Tenzar.

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