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Ospamox - instructions for use, reviews, analogs and formulations (granules and powder for the preparation of 125 mg suspension, 250 mg and 500 mg, 1000 mg tablets and capsules) antibiotic for the treatment of infections in adults, children and in pregnancy

Ospamox - instructions for use, reviews, analogs and formulations (granules and powder for the preparation of 125 mg suspension, 250 mg and 500 mg, 1000 mg tablets and capsules) antibiotic for the treatment of infections in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Ospamox. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ospomox antibiotic in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ospamox in the presence of existing structural analogues. Use for the treatment of infectious diseases in adults, children, as well as during pregnancy and lactation.

 

Ospamox - an antibiotic of a group of semisynthetic penicillins of a wide spectrum of action. It is a 4-hydroxyl analogue of ampicillin. Has a bactericidal effect. It is active against aerobic gram-positive bacteria: Staphylococcus spp. (except for strains producing penicillinase) (staphylococcus), Streptococcus spp (streptococcus); aerobic Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli (E. coli), Shigella spp. (Shigella), Salmonella spp. (salmonella), Klebsiella spp. (Klebsiella).

 

Amoxicillin (the active substance of Ospamox) is resistant to microorganisms that produce penicillinase.

 

In combination with metronidazole, it shows activity against Helicobacter pylori (Helicobacter). It is believed that Amoxicillin inhibits the development of Helicobacter pylori resistance to metronidazole.

 

There is cross resistance between Ospamox and ampicillin.

 

The spectrum of antibacterial action expands with simultaneous use of amoxicillin and clavulanic acid beta-lactamase inhibitor. In this combination, amoxicillin activity increases with respect to Bacteroides spp., Legionella spp. (Legionella), Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other Gram-negative bacteria remain resistant.

 

Composition

 

Amoxicillin trihydrate + excipients.

 

Pharmacokinetics

 

When ingestion Ospamox quickly and completely absorbed from the digestive tract, does not break down in the acidic environment of the stomach. When the dose is doubled, the concentration also doubles. In the presence of food in the stomach does not reduce the total absorption. With intravenous, intramuscular administration and ingestion, similar concentrations of amoxicillin are achieved in the blood. The binding of amoxicillin with plasma proteins is about 20%. Widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver are reported. About 60% of the dose taken orally is excreted unchanged in the urine by glomerular filtration and tubular secretion; at a dose of 250 mg, the concentration of amoxicillin in urine is more than 300 μg / ml. Some amount of amoxicillin is determined in the feces. In small quantities, amoxicillin penetrates the blood-brain barrier (BBB) ​​with inflammation of the pia mater. Amoxicillin is removed by hemodialysis.

 

Indications

 

For use in the form of monotherapy and in combination with clavulanic acid: infectious and inflammatory diseases caused by sensitive microorganisms, incl.bronchitis, pneumonia, tonsillitis, otitis media, tracheitis, laryngitis, pyelonephritis, urethritis, cystitis, gastrointestinal infections (cholecystitis, cholangitis), gynecological infections, infectious diseases of the skin and soft tissues (furunculosis), listeriosis, leptospirosis, gonorrhea.

 

For use in combination with metronidazole: chronic gastritis in the phase of exacerbation, peptic ulcer of the stomach and duodenum in the acute phase associated with Helicobacter pylori.

 

Forms of release

 

Powder for the preparation of the suspension for ingestion 125 mg, 250 mg and 500 mg (the suspension is sometimes mistakenly called a syrup).

 

Granules for the preparation of a suspension for oral administration of 125 mg and 250 mg.

 

Capsules 250 mg.

 

Tablets coated with 500 mg and 1000 mg.

 

Instructions for use and dosage

 

Inside, squeezed a lot of water. Adults and adolescents - 1500-2000 mg per day; children - at a rate of 30-60 mg / kg per day. Treatment continues for 2-5 days after the disappearance of the symptoms. With streptococcal infection - at least 10 days.

 

In severe disease, the daily dose is increased: adults up to 6000 mg per day and children up to 100 mg / kg per day. Adults with acute infections of the digestive tract (typhoid, paratyphoid) and biliary tract,accompanied by an increase in body temperature, gynecological infections: 1500-2000 mg 3 times a day or 1000-1500 mg 4 times a day, with leptospirosis - 500-750 mg 4 times a day for 6-12 days, with chronic salmonellosis ( carriage) - 1500-2000 mg 3 times a day for 2-4 weeks. Prevention of secondary endocarditis in the removal of teeth: adults 3000-4000 mg for 1 hour before the intervention, if necessary, again - after 8-9 hours; children are prescribed a 1/2 adult dose.

 

How to dilute and take Ospamox suspension

 

Before using the drug, it is necessary to prepare a suspension, first add drinking water to half the vial, shake thoroughly until a uniform suspension is formed and top up with drinking water to the label on the vial. Before each use, the preparation should be shaken carefully. The drug is taken regardless of food intake, it is recommended to take the drug at regular intervals. The duration of the course of treatment and the dose of the drug is determined by the attending physician individually for each patient.

 

The daily dose for children should be divided into 2-3 divided doses.

 

Average dosage of suspension in children:

  • Children under the age of 1 year are usually prescribed 2.5-5ml suspension Ospamox 125 mg / 5ml 2 times a day.It is not recommended to dilute the suspension with tea or milk, but after taking the drug, you can give the child tea or water.
  • Children aged 1 to 3 years are usually prescribed 2.5-5ml suspension Ospamox 250 mg / 5ml 2 times a day.
  • Children aged 3 to 6 years are usually prescribed 5-7.5 ml suspension Ospamox 250 mg / 5 ml 2 times a day.
  • Children aged 6 to 10 years are usually prescribed 2.5-5ml suspension Ospamox 500 mg / 5ml 2 times a day.
  • Children aged 10 to 14 years are usually prescribed 5-7.5 ml suspension Ospamox 500 mg / 5 ml 2 times a day.

 

Children with a body weight of more than 40 kg of the drug is usually prescribed in doses corresponding to the doses recommended for adults.

 

Side effect

  • hives;
  • erythema;
  • angioedema;
  • rhinitis;
  • conjunctivitis;
  • fever;
  • pain in the joints;
  • eosinophilia;
  • anaphylactic shock;
  • possible development of superinfections (especially in patients with chronic diseases or reduced resistance of the body);
  • dizziness;
  • confusion of consciousness;
  • depression;
  • peripheral neuropathies;
  • convulsions;
  • nausea, vomiting;
  • anorexia;
  • diarrhea, constipation;
  • pain in epigastrium;
  • stomatitis;
  • pseudomembranous colitis;
  • interstitial nephritis;
  • cholestatic jaundice;
  • hepatitis;
  • erythema multiforme;
  • toxic epidermal necrolysis;
  • exfoliative dermatitis.

 

Contraindications

  • Infectious mononucleosis;
  • lymphocytic leukemia;
  • severe GI infections accompanied by diarrhea or vomiting;
  • respiratory viral infections;
  • allergic diathesis;
  • bronchial asthma;
  • hay fever;
  • increased sensitivity to penicillins and / or cephalosporins;
  • diseases of the nervous system;
  • disorders of hematopoiesis;
  • lymphocytic leukemia.

 

Application in pregnancy and lactation

 

Ospamox penetrates the placental barrier, in small quantities excreted in breast milk.

 

If you need to use Ospamox during pregnancy, you should carefully weigh the expected benefit of therapy for the mother and the potential risk to the fetus.

 

Be wary of using amoxicillin during lactation (breastfeeding).

 

Use in children

 

Use in children is possible according to the dosing regimen.

 

Ospamox in combination with Metronidazole is not recommended for use in patients younger than 18 years.

 

special instructions

 

Use with caution in patients prone to allergic reactions.

 

Against the background of combined therapy with metronidazole, it is not recommended to drink alcohol.

 

Drug Interactions

 

Ospamox can reduce the effectiveness of oral contraceptives.

 

With the simultaneous use of amoxicillin with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin), synergy appears; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

 

Amoxicillin strengthens the effect of indirect anticoagulants suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.

 

Ospamox reduces the effect of drugs, in the process of metabolism which forms PABC.

 

Probenecid, diuretics, allopurinol, phenylbutazone, nonsteroidal anti-inflammatory drugs (NSAIDS) reduce tubular secretion of amoxycillin, which may be accompanied by an increase in its concentration in plasma.

 

Antacids, glucosamine, laxatives, aminoglycosides slow down and decrease, and Ascorbic acid increases the absorption of amoxicillin.

 

With the combined use of amoxicillin and clavulanic acid, the pharmacokinetics of both components do not change.

 

Analogues of the drug Ospamox

 

Structural analogs for the active substance:

  • Amoxisar;
  • Amoxicillin;
  • Amosin;
  • Gonoform;
  • Grunamox;
  • Danemox;
  • Flemoxin Solutab;
  • Hiconcile;
  • EcoBall.

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Reviews (3):
Guests
Blooming Sally
Assigned ospamox from purulent otitis media. He was treated for a long time and now his ears are covered with water and other cold. In principle, this antibiotic coped with its task and the otitis was cured. I did not see any special pores, so I only went to the toilet more often, but without diarrhea.
Guests
Perisate
Here we think to take a 7 month old baby. He has a sore throat, yet he is an antibiotic, we are afraid.
Administrators
admin
Perisate, Angina is treated with antibiotics, and already the choice of a specific drug on the treating doctor of the child.If your child Ospamox was recommended by a pediatrician, then what doubts can there be.

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