Ofloksin - instructions for use, antibiotic analogs, reviews and release forms (tablets 200 mg and 400 mg, solution for infusions in ampoules) of a drug for the treatment of prostatitis, bronchitis and cystitis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Ofloxin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of antibiotic Ofloksina in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ofloxin in the presence of available structural analogs.Use for the treatment of prostatitis, bronchitis and cystitis in adults, children, as well as during pregnancy and lactation. Interaction of the drug with alcohol.

Ofloxin - antimicrobial preparation of a broad spectrum of bactericidal action from the group of fluoroquinolones. Effects on the enzyme DNA-gyrase, which provides super-convolution and, thus, the stability of bacterial DNA (destabilization of DNA chains leads to the death of microorganisms).

It is active against microorganisms producing beta-lactamases, and fast-growing atypical mycobacteria, incl. Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus epidermidis), Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli (E. coli), Citrobacter spp., Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Hafnia spp., Proteus spp., Salmonella spp. (salmonella), Shigella spp. (shigella), Yersinia enterocolitica, Campylobacter jejuni, Aeromonas hydrophila, Plesiomonas shigelloides, Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Haemophilus ducreyi, Chlamydia spp. (chlamydia), Legionella spp. (legionella), Serratia spp., Providencia spp., Bordetella parapertussis, Bordetella pertussis, Moraxella catarrhalis, Propionibacterium acnes, Brucella spp.

Different sensitivity to the drug possess Enterococcus faecalis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus viridans, Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter spp., Mycoplasma hominis (mycoplasma), Mycoplasma pneumoniae, Mycobacterium tuberculosis, and Mycobacterium fortuitum, Ureaplasma urealyticum (Ureaplasma) Clostridium perfringens, Corynebacterium spp., Helicobacter pylori, Listeria monocytogenes, Gardnerella vaginalis.

In most cases, the drug is not sensitive to: Nocardia asteroides, anaerobic bacteria (Bacteroides spp., Peptococcus spp., Peptostreptococcus spp., Eubacterium spp., Fusobacterium spp., Clostridium difficile).

Not active against Treponema pallidum.

Composition

Ofloxacin + excipients.

Pharmacokinetics

After taking the medication, the absorption is rapid and complete (95%). Bioavailability is more than 96%. Eating can slow suction, but does not have a significant effect on bioavailability. Binding to plasma proteins - 20-25%.

Ofloxacin penetrates into many tissues and body fluids, including. saliva, bronchial secretion, bile, urine, tear and spinal fluid, pus, into the lungs, the prostate gland, skin, white blood cells, alveolar macrophages, soft tissues, bones, abdominal and pelvic organs. Well penetrates the blood-brain barrier (GEB), the placental barrier, excreted in breast milk. Penetrates into cerebrospinal fluid with inflamed and non-inflamed meninges (14-60%). Do not cumulate. Metabolized in the liver (about 5%) to form the N-oxide Ofloxacin and dimethylfloxacin. It is excreted by the kidneys in unchanged form - 75-90%, with bile - about 4%. The extrarenal clearance is less than 20%.

Indications

Infectious-inflammatory diseases caused by sensitive microorganisms:

• infections of the respiratory tract (bronchitis, pneumonia);
• infection of the ENT organs (sinusitis, pharyngitis, otitis media, laryngitis);
• infections of the skin and soft tissues;
• infection of bones and joints;
• Infectious and inflammatory diseases of the abdominal cavity and bile ducts;
• kidney infection (pyelonephritis) and urinary tract (cystitis, urethritis);
• infection of the pelvic organs (endometritis, salpingitis, oophoritis, cervicitis, parametritis, prostatitis) and genital organs (colpitis, orchitis, epididymitis);
• gonorrhea;
• chlamydia;
• meningitis.

Prevention of infections in patients with impaired immune status (including neutropenia).

Forms of release

Tablets coated with 200 mg and 400 mg.

Solution for infusions (injections in ampoules for injections).

Other medicinal forms of the drug, whether it be drops for the eyes or ointment, does not exist.

Instructions for use and dosing regimen

Pills

The drug is prescribed inside.

The dose of the drug and the duration of treatment depend on the severity and type of infection, as well as the sensitivity of microorganisms, the general condition of the patient and the function of the liver and kidneys.

Adults are prescribed in a daily dose of 200-600 mg. The duration of treatment is 7-10 days. A dose of up to 400 mg per day can be given in one session, preferably in the morning. A dose of more than 400 mg per day should be divided into 2 divided doses with an equal period of time.

In severe infections or in the treatment of patients with excessive body weight, the daily dose can be increased to 800 mg.

In uncomplicated infections of the lower parts of the urinary tract drug prescribed at a dose of 200 mg per day for 3-5 days.

With gonorrhea prescribed 400 mg once.

In liver failure, the maximum daily dose is 400 mg.

The initiated treatment with ofloxacin intravenously can be continued with the drug in the form of tablets at the same dose (with the improvement of the patient's condition).

Tablets should be taken whole, with water, before or during meals. It is necessary to avoid simultaneous reception with antacids.

Ampoules

Doses are selected individually depending on the location and severity of the infection, as well as the sensitivity of microorganisms, the general condition of the patient and the function of the liver and kidneys.

Intravenous drip introduction begins with a single dose of 200 mg, which is injected slowly for 30-60 minutes. When the patient's condition is improved, they are transferred to oral intake of the drug at the same daily dose.

With infections of the urinary tract drug prescribed in a dose of 100 mg 1-2 times a day.

With infections of the kidneys and genitalia - 100-200 mg 2 times a day.

For infections of the respiratory tract, as well as ENT organs, infections of the skin and soft tissues, bones and joints, infections of the abdominal cavity, septic infections - 200 mg 2 times a day. If necessary, increase the dose to 400 mg twice a day.

For the prevention of infections in patients with a marked decrease in immunity - in / in drip 200 mg in a 5% solution of glucose. The duration of the infusion is 30 minutes. Use only freshly prepared solutions.

Side effect

• anorexia;
• nausea, vomiting;
• diarrhea;
• flatulence;
• abdominal pain (including gastralgia);
• cholestatic jaundice;
• pseudomembranous enterocolitis;
• hepatitis;
• headache;
• dizziness;
• uncertainty of movements;
• tremor;
• convulsions;
• numbness and paresthesia of the limbs;
• nightmarish dreams;
• psychotic reactions;
• anxiety;
• increased excitability;
• phobias;
• depression;
• confusion of consciousness;
• hallucinations;
• increased intracranial pressure;
• violation of color perception;
• diplopia;
• impairment of taste, smell, hearing and balance;
• tachycardia;
• a decrease in blood pressure;
• vasculitis;
• collapse;
• arthralgia;
• tenosynovitis;
• rupture of the tendon;
• muscle weakness;
• leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic and aplastic anemia;
• point hemorrhages (petechiae);
• bullous hemorrhagic dermatitis;
• papular rash with a crust;
• vasculitis;
• photosensitization;
• acute interstitial nephritis;
• impaired renal function;
• increased urea in the blood;
• skin rash;
• itching;
• hives;
• fever;
• angioedema;
• bronchospasm;
• Stevens-Johnson syndrome;
• Lyell's syndrome;
• exudative erythema multiforme;
• anaphylactic shock;
• dysbiosis;
• superinfection;
• vaginitis.

Contraindications

• epilepsy (including in the anamnesis);
• reduction of convulsive threshold (including after traumatic brain injury, stroke or inflammatory processes in the central nervous system);
• the defeat of the tendons during the previous treatment with quinolones;
• age to 18 years (because the skeleton has not been completed);
• pregnancy;
• lactation (breastfeeding);
• deficiency of glucose-6-phosphate dehydrogenase;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

Use in children

Contraindicated in children and adolescents under the age of 18 (since the skeleton has not been completed).

special instructions

Ofloksin is not a drug of choice for pneumonia caused by pneumococci.

Not indicated for the treatment of acute tonsillitis.

It is not recommended to use the drug for more than 2 months. Avoid exposure to sunlight or UV irradiation (mercury quartz lamps, solarium).

In the event of side effects from the central nervous system, allergic reactions, pseudomembranous colitis, drug withdrawal is necessary. With pseudomembranous colitis, confirmed colonoscopically and / or histologically, oral administration of Vancomycin and Metronidazole is indicated.

It should be borne in mind that with the use of Ofloksin, rarely occurring tendonitis can lead to rupture of tendons (mainly Achilles tendon), especially in elderly patients. In case of symptoms of tendonitis, it is necessary to immediately stop treatment, immobilize the Achilles tendon and consult an orthopedist.

When using the drug, women are not recommended to use tampons due to the increased risk of developing vaginal candidiasis.

Against the backdrop of treatment, myasthenia flow may worsen, and porphyria attacks may be more frequent in predisposed patients.

When using the drug, false-negative results are possible with bacteriological diagnosis of tuberculosis (prevents the release of Mycobacterium tuberculosis).

In patients with impaired liver or kidney function, it is necessary to monitor the concentration of ofloxacin in the blood plasma. In severe renal and hepatic insufficiency, the risk of toxic effects increases (dose adjustment is required).

During the treatment with the drug should avoid drinking alcohol.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

Foods, antacids containing aluminum, calcium, magnesium, or iron salts reduce the absorption of ofloxacin, forming insoluble complexes (therefore, the interval between prescribing of Ofloxin and these drugs should be at least 2 hours).

When co-administered with drugs that extend the QT interval (antiarrhythmic drugs of classes 1A and 3, tricyclic antidepressants, macrolides), the risk of prolonging the QT interval increases.

With simultaneous use ofloxacin reduces the clearance of theophylline by 25% (with this combination should reduce the dose of theophylline).

With simultaneous use of cimetidine, furosemide, Methotrexate and drugs that block tubular secretion, increase the concentration of ofloxacin in plasma.

Ofloxacin increases the concentration of glibenclamide in the blood plasma.

At simultaneous reception with antagonists of vitamin K it is necessary to carry out the control of a condition of coagulating system of blood.

When combined with non-steroidal anti-inflammatory drugs (NSAIDs), derivatives of nitroimidazole and methylxanthines, the risk of developing neurotoxic effects increases.

At simultaneous appointment with glucocorticosteroids (GCS), the risk of rupture of tendons increases, especially in the elderly.

When administered with drugs that alkalinize urine (inhibitors of carbonic anhydrase, citrates, sodium bicarbonate), the risk of developing crystalluria and nephrotoxic effects increases.

Analogues of the drug Ofloxin

Structural analogs for the active substance:

• Vero Ofloxacin;
• Glaoufos;
• Dancyl;
• Zanotsin;
• Zofloks;
• Oflo;
• Ofloks;
• Ofloxabol;
• Ofloxacin;
• Ofloxin 200;
• Oflomak;
• Oflotsid;
• Oflotsid forte;
• Tarevid;
• Tariferide;
• Taricin;
• Uniflox;
• Floxal.

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