En DE FR ES PL
Ofloxacin - instructions for use, analogs, testimonials and release forms (tablets 100 mg, 200 mg and 400 mg, injections in ampoules, eye ointment 0.3%) of an antibiotic preparation for the treatment of bronchitis and pneumonia in adults, children and pregnancy

Ofloxacin - instructions for use, analogs, testimonials and release forms (tablets 100 mg, 200 mg and 400 mg, injections in ampoules, eye ointment 0.3%) of an antibiotic preparation for the treatment of bronchitis and pneumonia in adults, children and pregnancy

In this article, you can read the instructions for using the drug Ofloxacin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of antibiotic Ofloxacin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ofloxacin in the presence of existing structural analogues.Use for the treatment of bronchitis and pneumonia in adults, children, as well as in pregnancy and lactation. Interaction of the drug with alcohol.

 

Ofloxacin - a broad-spectrum antimicrobial agent from the group of fluoroquinolones, acts on the bacterial DNA-gyrase enzyme, which provides super-convoliation, and so on. stability of bacterial DNA (destabilization of DNA chains leads to their death). Has a bactericidal effect.

 

The antimicrobial spectrum includes gram-positive and gram-negative aerobes, anaerobes.

 

Other: Chlamydia trachomatis, Chlamydia pneumoniae, Gardnerella vaginalis, Legionella pneumophila, Mycoplasma hominis, Mycoplasma pneumoniae, Ureaplasma urealyticum. Most cases are insensitive: Nocardia asteroides, anaerobic bacteria (including Bacteroides spp., Peptococcus spp., Peptostreptococcus spp., Eubacterium spp., Fusobacterium spp., Clostridium difficile), Enterococcus spp., Most Streptococcus spp., Not acts on Treponema pallidum.

 

Pharmacokinetics

 

Absorption after oral administration is rapid and complete (95%). Food can slow absorption, but does not have a significant effect on bioavailability. Distribution: cells (leukocytes, alveolar macrophages), skin, soft tissues, bones, abdominal and pelvic organs, respiratory system, urine, saliva, bile, secretion of the prostate; well penetrates the blood-brain barrier, the placental barrier, is secreted with the mother's milk. It penetrates into the cerebrospinal fluid (14-60%).Metabolized in the liver (about 5%) to form the N-oxide ofloxacin and dimethylfloxacin. It is excreted by the kidneys - 75-90% (unchanged), about 4% - with bile. The extrarenal clearance is less than 20%.

 

Indications

 

Infectious-inflammatory diseases caused by microorganisms sensitive to ofloxacin:

  • respiratory tract (bronchitis, pneumonia);
  • ENT organs (sinusitis, pharyngitis, otitis media, laryngitis, tracheitis);
  • skin, soft tissues (furuncles, carbuncles);
  • bones, joints;
  • organs of the abdominal cavity and biliary tract (cholecystitis, cholangitis);
  • kidneys (pyelonephritis);
  • uncomplicated infections of the lower parts of the urinary tract (cystitis, urethritis);
  • genitals and pelvic organs (endometritis, salpingitis, oophoritis, cervicitis, parametritis, prostatitis, colpitis, orchitis, epididymitis);
  • gonorrhea;
  • chlamydia;
  • ureaplasmosis;
  • prevention of infections in patients with impaired immune status (including neutropenia).

 

Forms of release

 

Tablets coated with 100 mg, 200 mg and 400 mg.

 

Solution for infusions (injections in ampoules for injections).

 

Eye ointment 0.3%.

 

Other forms of release, whether drops or capsules, the antibiotic Ofloxacin does not exist.

 

Instructions for use and dosage

 

Pills

 

Inside.The dose is selected individually depending on the location, the severity of the infection, the sensitivity of microorganisms, as well as the general condition of the patient and the function of the liver and kidneys. Adults - 200-800 mg per day, the course of treatment - 7-10 days, the frequency of application - 2 times a day. A dose of up to 400 mg per day can be given in one session, preferably in the morning. With gonorrhea - 400 mg once.

 

In patients with impaired renal function (with creatinine clearance 50-20 ml / min) 100-200 mg per day. When creatinine clearance is less than 20 ml / min - 100 mg every 24 hours; with hemodialysis and peritoneal dialysis - 100 mg every 24 hours.

 

The maximum daily dose for liver failure is 400 mg per day. Tablets are taken whole, washed down with water, before or during meals. The duration of treatment is determined by the sensitivity of the pathogen and the clinical picture; treatment should continue for at least 3 more days after the disappearance of the symptoms of the disease and complete normalization of body temperature. In the treatment of uncomplicated and complicated infections of the lower urinary tract treatment course - 7 and 10 days respectively, with prostatitis - up to 6 weeks, with infections of the pelvic organs - 10-14 days, with infections of the respiratory system and skin - 10 days.

 

Ampoules

 

The drug is administered intravenously drip (dropper).Doses are selected individually depending on the location and severity of the infection, as well as the sensitivity of microorganisms, the general condition of the patient and the function of the liver and kidneys.

 

Therapy is started with intravenous drip (for 30-60 minutes) of the drug at a dose of 200 mg. When the patient's condition is improved, they are transferred to oral intake of the drug at the same daily dose.

 

With infections of the urinary tract, the drug is prescribed at 100 mg 1-2, with infections of the kidneys and genitals - from 100 to 200 mg 2 times a day; with infections of the respiratory tract, as well as ENT organs, infections of the skin and soft tissues, bones and joints, infections of the abdominal cavity, septic infections - 200 mg twice a day. If necessary, increase the dose to 400 mg twice a day.

 

For the prevention of infections in patients with a marked decrease in immunity - 400-600 mg per day.

 

Ointment

 

Locally. For the lower eyelid of the affected eye 2-3 times a day lay a 1 cm strip of ointment (0.12 mg ofloxacin). When chlamydial infections ointment is poured 5-6 times a day.

 

For the introduction of the ointment, gently pull the lower eyelid down and, lightly pressing on the tube, insert into the conjunctival bag a strip of ointment 1 cm long.Then close the eyelid and move the eyeball to distribute the ointment evenly.

 

The duration of treatment is no more than 2 weeks (with chlamydial infections, the course is extended to 4-5 weeks).

 

Side effect

  • gastralgia;
  • anorexia;
  • nausea, vomiting;
  • diarrhea;
  • flatulence;
  • abdominal pain;
  • pseudomembranous enterocolitis;
  • headache;
  • dizziness;
  • uncertainty of movements;
  • tremor;
  • convulsions;
  • numbness and paresthesia of the limbs;
  • nightmarish dreams;
  • anxiety;
  • psychomotor agitation;
  • depression;
  • confusion of consciousness;
  • hallucinations;
  • increased intracranial pressure;
  • violation of color perception;
  • a violation of taste, smell and balance;
  • myalgia;
  • arthralgia;
  • rupture of the tendon;
  • tachycardia;
  • decrease in blood pressure (with a sharp decrease in blood pressure, discontinuation);
  • vasculitis;
  • collapse;
  • leukopenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, hemolytic and aplastic anemia;
  • acute interstitial nephritis;
  • impaired renal function;
  • pinpoint hemorrhages;
  • dermatitis bullous hemorrhagic;
  • papular rash, indicating the defeat of blood vessels (vasculitis);
  • skin rash;
  • itching;
  • hives;
  • allergic pneumonitis;
  • allergic nephritis;
  • fever;
  • angioedema;
  • bronchospasm;
  • Stevens-Johnson syndrome and Lyell syndrome;
  • photosensitization;
  • multiforme exudative erythema;
  • anaphylactic shock;
  • dysbiosis;
  • superinfection;
  • hypoglycemia (in patients with diabetes mellitus);
  • vaginitis;
  • pain and redness at the injection site;
  • thrombophlebitis.

 

Contraindications

  • deficiency of glucose-6-phosphate dehydrogenase;
  • epilepsy (including in the anamnesis);
  • lowering the threshold of convulsive readiness (including after traumatic brain injury, stroke or inflammatory processes in the central nervous system);
  • age to 18 years (until the bone growth of the skeleton is completed);
  • pregnancy;
  • lactation;
  • hypersensitivity to the drug.

 

Application in pregnancy and lactation

 

The drug is contraindicated for use in pregnancy and lactation.

 

Use in children

 

The drug is contraindicated in children and adolescents under 18 years of age, not completed growth of the skeleton.

 

In children, the drug is used only with life-threatening infections, taking into account the expected clinical efficacy and the potential risk of side effects when it is impossible to use less toxic drugs. The average daily dose in this case is 7.5 mg / kg of body weight, the maximum - 15 mg / kg.

 

special instructions

 

Ofloxacin is not a drug of choice for pneumonia caused by pneumococci, not shown in the treatment of acute tonsillitis.

 

It is not recommended to apply for more than 2 months. Against the background of the use of the drug can not be exposed to sunlight, UV radiation.

 

If there are side effects from the central nervous system, allergic reactions, pseudomembranous colitis, it is necessary to cancel the drug.

 

Rarely developing tendonitis can lead to rupture of tendons (mainly Achilles tendon), especially in elderly patients. In case of signs of tendonitis, it is necessary immediately to stop treatment, to immobilize the Achilles tendon and consult an orthopedist.

 

When using the drug, women are not recommended to use tampon type tampons due to the increased risk of developing candidiasis.

 

Against the backdrop of treatment, myasthenia flow may worsen, and porphyria attacks may be more frequent in predisposed patients.

 

There may be false-negative results in the bacteriological diagnosis of tuberculosis (prevents the release of Mycobacterium tuberculosis).

 

If there is a violation of the liver or kidney function, it is necessary to control the concentration of ofloxacin in the blood plasma. In severe renal and hepatic insufficiency, the risk of toxic effects increases (a decreasing dose adjustment is required).

 

Against the background of the use of the drug, you can not use ethanol (alcohol).

 

Impact on the ability to drive vehicles and manage mechanisms

 

When using the drug should refrain from engaging in potentially dangerous activities that require increased attention and high speed of psychomotor reactions.

 

Drug Interactions

 

With simultaneous use ofloxacin reduces the clearance of theophylline by 25% (with simultaneous use should reduce the dose of theophylline).

 

With simultaneous use of cimetidine, furosemide, Methotrexate and drugs that block tubular secretion, increase the concentration of ofloxacin in plasma.

 

Ofloxacin increases the concentration of glibenclamide in plasma.

 

At simultaneous reception with indirect anticoagulants-antagonists of vitamin K it is necessary to carry out the control of a condition of coagulating system of blood.

 

When combined with non-steroidal anti-inflammatory drugs (NSAIDs), derivatives of nitroimidazole and methylxanthines, the risk of developing neurotoxic effects increases.

 

At simultaneous appointment with glucocorticosteroids (GCS), the risk of rupture of tendons increases, especially in the elderly.

 

When administered with drugs that alkalinize urine (inhibitors of carbonic anhydrase, citrates, sodium bicarbonate), the risk of crystalluria and nephrotoxic effects increases.

 

Pharmaceutical interaction

 

The solution of ofloxacin is compatible with the following infusion solutions: isotonic sodium chloride solution, Ringer's solution, 5% fructose solution, 5% Dextrose solution (glucose).

 

Analogues of the medicinal preparation Ofloxacin

 

Structural analogs for the active substance:

  • Vero Ofloxacin;
  • Glaoufos;
  • Dancyl;
  • Zanotsin;
  • Zofloks;
  • Oflo;
  • Ofloks;
  • Ofloxabol;
  • Ofloxacin DS;
  • Ofloxacin Protek;
  • Ofloxacin Stada;
  • Ofloxacin Promed;
  • Ofloxacin Teva;
  • Ofloxin;
  • Ofloxin 200;
  • Oflomak;
  • Oflotsid;
  • Oflotsid forte;
  • Tarevid;
  • Tariferide;
  • Taricin;
  • Uniflox;
  • Floxal.

Similar medicines:

Other medicines:

Reviews (13):
Guests
Yuliya
Refused to use the drug, because there were side effects such as dizziness, decreased concentration, sleep disorders.
Guests
Alyona
They refused the drug, since the pressure began to gallop.
Guests
Lexi
The doctor prescribed this medicine from gonorrhea. Took a long and tedious, since the diarrhea was permanent already on the 5th day of admission. It can be seen that everything kills everything well, since he got rid of his gonorrhea, but the stomach then restored the month with various yogurt and linseed to get everything back to normal. So it is possible, but only on the recommendation of a doctor, do not try yourself - a very strong antibiotic.
Administrators
admin
Question from the site visitor Victoria11, moved to the required section:
Hello. The gynecologist has appointed ofloksatsin + metronidazolum, whether it is possible to accept together with them omeprazole, a pancreatin and a bronhomunal?

Victoria11, Yes, all the medications you specify are combined and according to the instruction of negative side effects, when a joint admission should not be. True, there are a lot of drugs, there are also quite strong antibiotics, so that the side effect of an isolated individual treatment component is not excluded. Care must be taken to monitor your sensations during treatment.
In the treatment of colds with high temperature, with ofloxacin in the treatment scheme, the appetite completely lost, there was a taste disorder, for many days all food had the same taste. All this has not yet come back to normal within 3 weeks after she completed the course of treatment. There was sometimes a metallic ringing in my ears, a terrible memory. Did anyone have this when taking ofloxacin? In the instructions to him, hearing and taste disorders, decreased appetite are indicated as possible side effects.

Yet.Mother (age-related, active and energetic before the illness) at the beginning of the year caught a cold, had bronchitis, and ofloxacin was also prescribed. I fell in time right after treatment to the hospital with tachycardia (which the therapist mixed up with another disease) and acute headache. In ofloxacin, according to the instructions, tachycardia and headache are possible as a side effect, how often does it occur in practice? It that, too there were by-effects of ofloxacinum?
Administrators
admin
Natalia 08042015, The statistics thing is thin. Someone has a side effect (that means 100% probability), someone does not (it means 0% probability). I here one will not understand, if Ofloksatsin already gave any by-effects why you continue to pump up the mother with such strong antibiotics. Perhaps you should start with drugs weaker and the problem with the side effects of a strong antibiotic will disappear by itself.
Pumping? In no case.

Mom was given ofloxacin at the beginning of this year, when she caught a cold.After this treatment, she again went to the hospital and her mixed up with tachycardia atrial fibrillation, and complete LBBB admitted for a heart attack and was being treated for a heart attack (City cardiologist said that LBBB could arise with a strong cough, and he and my mother was very heavy).

Recently, I hurt myself (first cold, then bronchitis) and came under the most ofloxacin as intended, has suffered and I realized that my mother's tachycardia and acute headaches can easily be pobochki antibiotic. To give my mom ofloxacin after such, of course, I will not risk, and in case of his recommendation I will talk with a doctor who will recommend it so that he knows about a possible reaction.
Administrators
admin
Natalia 08042015, It is clear, it means that your doctors went to fashion for Ofloxacin. I would start treatment with antibiotics weaker. So it will be more correct.
Guests
Yana
My gallbladder got worse and I received a drug. For 5 days of treatment, everything went away, and then I could not sleep and there were severe pains, thank you! I liked ofloxacin, I drank 2 r per day for 200 mg.
Guests
Islam
At the moment I take ofloxacin 400 mg, first 3 times a day, and then 2 times. Today is the 7th day, while there are no side effects. The doctor appointed him for inflammation of the urinary canals.
Guests
Crimea
And after the single tablet ofloxacin I had a swelling of Quincke. Thanks to the quick arrival of the ambulance, everything worked out. Be careful!
Guests
Zhenya
After taking one pill, severe headaches, dizziness, a whole day's muddiness, still hurt my heart, I have a 2-degree malformation. The doctor wrote the urologist, the name was another - Norfloxacin, was sold in Ukraine, the principle of the drug is the same, but before such pobochek was not. I bought specially Ofloxacin Teva, the wife drank Ofloxacin, the Russian company Ozone, had the same symptoms as me, after the second pill I threw.
Guests
Lyolya
It is difficult to judge the effectiveness of an antibiotic, because everything depends on the spectrum of action and the correctness of the diagnosis.But in our case ofloxacin showed itself from the best side, my husband quickly helped to remove the acute stage of prostatitis.

Rules for publishing reviews and visitor questions