Midokalm - instructions for use, analogs, reviews and release forms (tablets 50 mg and 150 mg, injections in ampoules (Richter) for injection) of the drug for the treatment of osteochondrosis, arthrosis in adults, children and pregnancy
In this article, you can read the instructions for using the drug Midokalm. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of medical experts on the use of Midokalm in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Midokalm in the presence of existing structural analogues. Use for the treatment of osteochondrosis, arthrosis and other cervical, lumbar and articular syndromes in adults, children, as well as during pregnancy and lactation.
Midokalm - Muscle relaxant of central action.
Tolperisone hydrochloride (the active substance of the drug Midokalm) is the central muscle relaxant. The exact mechanism of action is unknown. As a result of membrane-stabilizing action, it prevents the excitation in primary afferent fibers, blocking mono- and polysynaptic reflexes of the spinal cord. Probably, the secondary mechanism of action is to block the release of the transmitter by blocking the entry of calcium ions into the synapses. Reduces reflex readiness in the reticulospinal tract of the brainstem. Strengthens the peripheral circulation. This effect is not related to the effect of the drug on the central nervous system and may be due to the weak antispasmodic and anti-adrenergic action of tolperisone.
Pharmacokinetics
After ingestion, Tolperisone is well absorbed from the digestive tract. Tolperisone is metabolized in the liver and kidneys. Pharmacological activity of metabolites is unknown. It is excreted by the kidneys in the form of metabolites (99%).
Indications
- treatment of pathologically increased tone and spasms of the striated muscle,arising from organic diseases of the central nervous system (including the defeat of pyramidal tracts, multiple sclerosis, stroke, myelopathy, encephalomyelitis);
- treatment of increased tone and muscle spasms, muscle contractures accompanying diseases of the movement organs (for example, spondylosis, spondyloarthrosis, cervical and lumbar syndromes, arthrosis of large joints);
- Restorative treatment after orthopedic and traumatological operations;
- in the combination therapy of obliterating vascular diseases (obliterating atherosclerosis, diabetic angiopathy, thromboangiitis obliterans, Reynaud's disease, diffuse scleroderma), diseases arising from the disorder of vascular innervation (acrocyanosis, intermittent angioedema dysbasia).
Forms of release
Tablets, film-coated 50 mg and 150 mg.
Solution for injections (injections) (in ampoules for injections of 100 mg + 2.5 mg / ml) under the name Midokalm - Richter.
Instructions for use and dosage
Established individually, depending on the clinical picture and the tolerability of the drug.
Adults appoint 50 mg 2-3 times a day, gradually increasing the dose to 150 mg per day 2-3 times a day.
Tablets are taken after meals, without chewing, with a small amount of water.
For children aged 1 to 6 years, Mydocalm is administered orally at a daily dose of 5 mg / kg (in 3 divided doses during the day); at the age of 7-14 years - in a daily dose of 2-4 mg / kg in 3 divided doses. The tablet, covered with a shell, should be ground if the child can not swallow it. For children, only the use of coated tablets is allowed, 50 mg.
Injuries Midokalm - Richter
Adults daily appoint IM in 100 mg 2 times a day or in / in 100 mg once a day.
Side effect
- nausea, vomiting;
- feeling of discomfort in the abdomen;
- headache;
- itching;
- erythema;
- hives;
- angioedema;
- anaphylactic shock;
- bronchospasm;
- muscle weakness;
- arterial hypotension.
With decreasing dose, adverse reactions usually go away.
Contraindications
- myasthenia gravis;
- children under 1 year;
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
Application of Midokalma during pregnancy (especially in the first trimester) and during lactation (breastfeeding) is possible only if the intended benefit to the mother exceeds the potential risk to the fetus or baby.
Impact on the ability to drive vehicles and manage mechanisms
The use of the drug does not affect the ability of patients to perform work that requires increased attention and speed of psychomotor reactions.
Drug Interactions
Data on the interaction that limits the use of Midokalm is not available.
With the simultaneous use of Midokalm enhances the effect of niflumic acid, so if necessary, this combination should reduce the dose of niflumic acid.
Although tolperisone has an effect on the central nervous system, the drug does not cause sedation, so it can be used in combination with sedatives, hypnotics, and preparations containing ethanol.
Does not affect the effect of ethanol (alcohol) on the central nervous system.
Means for general anesthesia, peripheral muscle relaxants, psychotropic drugs, clonidine enhance the effect of tolperisone.
Analogues of medicinal medicine Midokalm
Structural analogs for the active substance:
- Tolizor;
- Tolperisone;
- Tolperisone hydrochloride.
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