Ornidazole - instructions for use, antibiotic analogs, testimonials and release forms (500 mg tablets, injections in injections) of a medicament for the treatment of giardiasis and trichomoniasis in adults, children and pregnancy. Composition and alcohol
In this article, you can read the instructions for using the drug Ornidazole. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of the antibiotic Ornidazole in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ornidazole in the presence of existing structural analogues.Use to treat giardiasis and trichomoniasis in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.
Ornidazole - antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of ornidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of ornidazole reacts with DNA cells of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
It is active against Trichomonas vaginalis (Trichomonads), Gardnerella vaginalis (Gardnerella), Giardia intestinalis, Entamoeba histolitica, Lamblia spp. (lamblia), as well as obligate anaerobes Bacteroides spp. (including Bacteroides fraglis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonela spp., Prevotella (P.bivia, P. buccae, P.disiens), and some gram-positive microorganisms (Eubacterium spp ., Clostridium).
Orniferous microorganisms are not sensitive to ornidazole.
Composition
Ornidazole + excipients (tablets).
Metronidazole + auxiliary substances (solution for infusions).
Pharmacokinetics
After oral administration, ornidazole is rapidly absorbed in the gastrointestinal tract (GIT). Absorption is about 90%. The association of ornidazole with proteins is about 13%.Penetrates into the cerebrospinal fluid, other body fluids and tissues. Ornidazole is metabolized in the liver with the formation of mainly 2-hydroxymethyl and alpha-hydroxymethylmetabolites. Both metabolites are less active against Trichomonas vaginalis and anaerobic bacteria than unchanged ornidazole. After a single dose, 85% of the dose is withdrawn within the first 5 days, mainly in the form of metabolites. About 4% of the accepted dose is excreted through the kidneys in unchanged form, and 20-25% by the intestine.
Indications
- trichomoniasis;
- amebiasis: amoebic dysentery, extraintestinal amoebiasis (including amoebic liver abscess);
- giardiasis;
- prevention of infections caused by anaerobic bacteria, in operations on the colon and in gynecology.
Forms of release
The tablets covered with a cover of 500 mg.
Solution for infusions (injections in ampoules for injections).
Instructions for use and dosing regimen
Pills
Ornidazole is taken orally after a meal, with a small amount of water.
With trichomoniasis. Treatment is carried out for 5 days, 500 mg orally 2 times a day (morning and evening). In order to reduce the risk of re-infection at the same time, the course treatment of the sexual partner is carried out.
Children older than 12 years - inside 25 mg / kg for 5 days.
With intestinal amebiasis. Adults and children weighing more than 35 kg - 1.5 g once a day, with a body weight of more than 60 kg - 2 g per day. Children with a body weight of less than 35 kg - 40 mg / kg per day. The course of treatment is 3 days.
With extraintestinal amebiasis. Adults and children over 12 years of age - 0.5 grams inside, morning and evening for 5-10 days. With giardiasis
Adults and children weighing more than 35 kg - 1.5 g per day; Children weighing less than 35 kg - 40 mg / kg per day. Duration of treatment is 1-2 days.
Prevention of infections caused by anaerobic bacteria 0.5-1 g before surgery, after surgery - 0.5 g 2 times a day for 3-5 days.
Ampoules
Intravenous administration of ornidazole is indicated in severe infections, as well as in the absence of the possibility of taking the drug inside.
Usually a single dose for adults and children over 12 years is 500 mg, I / O speed of a continuous (jet) or dropwise administration (dropper) is 5 ml per min. The interval between the administrations is 8 hours. The duration of treatment is determined individually. The maximum daily dose is no more than 2 g. According to the indications, depending on the nature of the infection, the transition to maintenance therapy with oral forms of Metronidazole is carried out.
When trichomoniasis: adults - 0.5 g 3 times a day for 5 days or 1 g in combination with intravaginal injection of 500 mg (vaginal tablets) at night. Children - in a single dose, at the rate of 25 mg / kg of body weight per day.
With amoebic dysentery adults and children weighing over 35 kg - 1.5 g per day with a body weight of more than 60 kg 2 g per day. Children with body weight less than 35 kg 40 mg / kg per day. Duration of treatment - 3 days.
For the treatment of other forms of amoebiasis: adults and children weighing more than 35 kg - 0.5 grams orally 2 times a day, with a weight of 35 kg - 25 mg / kg once for 5-10 days. Single doses for children: aged 7-12 years - 0.375 g; 1-6 years - 0.25 g; up to 1 year - 0.125 g; multiplicity of appointment -2 times a day (morning and evening); the duration of treatment is 5-10 days.
With giardiasis: adults and children weighing over 35 kg - 1.5 g per day; Children with body weight up to 35 kg - 40 mg / kg per day. Duration of treatment is 1-2 days.
Prevention of postoperative infectious complications caused by anaerobic bacteria - 0.5 g before surgery, then every 12 hours for 0.5 g, for 3-5 days.
Side effect
- drowsiness;
- headache;
- abnormal gastrointestinal function (including nausea);
- dizziness;
- tremor;
- stiff muscles;
- violation of coordination of movement;
- convulsions;
- fatigue;
- temporary loss of consciousness;
- sensory or mixed peripheral neuropathy;
- perversion of taste sensations;
- change in the activity of "liver" enzymes;
- allergic reactions.
Contraindications
- hypersensitivity;
- pregnancy (1 trimester);
- lactation period;
- in connection with the indivisibility of the dosage form is not prescribed to children with a body weight of less than 12 kg (for tablets).
Application in pregnancy and lactation
Contraindicated in pregnancy (1st trimester) and lactation.
Use in children
Due to the indivisibility of the dosage form, children with a body weight of less than 12 kg (for tablets) are not prescribed.
special instructions
With caution apply for diseases of the central nervous system (including epilepsy, multiple sclerosis), liver disease, alcoholism.
When treating trichomoniasis, simultaneous treatment of sexual partners should be carried out.
Drug Interactions
Strengthens the effect of anticoagulants coumarinic series, prolongs the miorelaksiruyuschee effect of vecuronium bromide.
Ornidazole tablets are compatible with ethanol (alcohol) (does not inhibit acetaldehyde) in contrast to other imidazole derivatives (metronidazole).
Analogues of the drug Ornidazole
Structural analogs for the active substance:
- Avrazor;
- Gairo;
- Dazolik;
- Lornisol;
- Ornidazole Vero;
- Ornion;
- Ornisid;
- Ornisid Forte;
- Tiberal.
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