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Magnesia - instructions for use, reviews, analogs and forms of release (injections in ampoules for intramuscular and intravenous injections, powder for the preparation of a suspension) of a medicinal product for the treatment of pressure in adults, children and in pregnancy

Magnesia - instructions for use, reviews, analogs and forms of release (injections in ampoules for intramuscular and intravenous injections, powder for the preparation of a suspension) of a medicinal product for the treatment of pressure in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Magnesia. Comments of visitors of the site - consumers of this medicine, as well as opinions of doctors of specialists on the use of Magnesia in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Magnesia in the presence of existing structural analogues.Use to treat constipation, reduce high blood pressure, carry out tjubazhi in adults, children, as well as during pregnancy and lactation.

 

Magnesia - ingestion has choleretic (reflex action on the receptors of the mucous membrane of the duodenum) and the laxative effect (due to the poor absorbability of the drug in the intestine it creates a high osmotic pressure, there is an accumulation of water in the intestine, the intestinal contents diluted, peristalsis is enhanced). It is an antidote for poisoning with salts of heavy metals. The onset of the effect is 0.5-3 hours, duration - 4-6 hours.

 

In parenteral administration, it has a hypotensive, sedative and anticonvulsive action, and diuretic, arteriodilatirtee, antiarrhythmic, vasodilating (on an artery) effect in high doses - kurarepodobnoe (inhibitory effect on neuromuscular transmission), tocolytic, hypnotic and narcotic effect, suppresses respiratory Centre. Magnesium is a physiological blocker of slow calcium channels and is able to displace it from binding sites.Regulates metabolic processes, interneuronal transmission and muscular excitability, prevents the entry of calcium through the presynaptic membrane, reduces the amount of acetylcholine in the peripheral nervous system and the central nervous system. Relaxes smooth muscles, reduces blood pressure (mostly increased), increases diuresis.

 

The mechanism of anticonvulsant action is associated with a decrease in the release of acetylcholine from neuromuscular synapses, while magnesium suppresses neuromuscular transmission, has a direct inhibitory effect on the central nervous system.

 

The antiarrhythmic effect of magnesium is due to a decrease in the excitability of cardiomyocytes, the restoration of ionic equilibrium, the stabilization of cell membranes, the violation of sodium current, a slow incoming calcium current and a unilateral potassium current. The cardioprotective effect is due to the expansion of the coronary arteries, the decrease in OPSS and platelet aggregation.

 

The tocolytic action develops as a result of inhibition of the contractile ability of the myometrium (decrease in absorption, binding and distribution of calcium in smooth muscle cells) under the influence of the magnesium ion, increasing blood flow in the uterus as a result of the expansion of its vessels.Magnesium is an antidote for poisoning with salts of heavy metals.

 

Systemic effects develop almost instantaneously after intravenous and 1 h after intramuscular injection. The duration of action with / in the introduction - 30 minutes, with / m - 3-4 hours.

 

Composition

 

Magnesium sulfate + auxiliary substances.

 

Pharmacokinetics

 

After ingestion, no more than 20% of the dose taken is absorbed. Penetrates through the blood-brain barrier (GEB) and the placental barrier, excreted in breast milk with a concentration that is 2 times higher than the concentration in the plasma. It is excreted by the kidneys, the rate of renal excretion is proportional to the concentration in the plasma and the level of glomerular filtration.

 

Indications

 

For oral administration:

  • constipation;
  • cholangitis;
  • cholecystitis;
  • dyskinesia of the gallbladder according to the hypotonic type (for carrying out tjubazhes);
  • duodenal sounding (to get a vesicle of bile);
  • Purification of the intestine before the diagnostic manipulation.

 

For parenteral administration:

  • arterial hypertension (including hypertensive crisis with the phenomena of cerebral edema);
  • the threat of premature delivery;
  • convulsions with gestosis;
  • hypomagnesemia (including increased need for magnesium and acute hypomagnesemia - tetany, impaired myocardial function);
  • polymorphic ventricular tachycardia (of the "pirouette" type);
  • eclampsia;
  • encephalopathy;
  • epileptic syndrome;
  • retention of urine;
  • poisoning with salts of heavy metals (mercury, arsenic, tetraethyl lead, barium).

 

Forms of release

 

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

 

Powder for suspension for oral administration in cans of 20 g, 25 g, 40 g, 50 g.

 

Instructions for use and dosing regimen

 

Intramuscularly or intravenously. Magnesia is used only according to the doctor's prescription. Doses are refined taking into account the therapeutic effect and the concentration of magnesium sulfate in the blood serum.

 

For hypertensive crises, inject in / m or iv slowly, 5-20 ml of 25% solution. With convulsive syndrome, spastic conditions, the drug is given in / m 5-20 ml of a 25% solution in combination with anxiolytic drugs with a pronounced central miorelaxing effect.

 

In acute poisoning with mercury, arsenic, tetraethyl lead 5-10% solution of magnesium sulfate is injected iv in 5-10 ml.

 

Side effect

  • bradycardia;
  • diplopia;
  • a sudden rush of blood to the face;
  • headache;
  • a decrease in blood pressure;
  • nausea, vomiting;
  • diarrhea;
  • flatulence;
  • thirst;
  • dyspnea;
  • blurred speech;
  • weakness;
  • decrease or loss of deep tendon reflexes;
  • depression of the respiratory center;
  • impaired conduction of the heart;
  • heart failure;
  • hyperhidrosis;
  • anxiety;
  • marked sedation;
  • polyuria;
  • atony of the uterus;
  • violation of electrolyte balance (increased fatigue, asthenia, confused consciousness, arrhythmia, convulsions).

 

Contraindications

  • chronic renal failure of a serious degree;
  • increased sensitivity to magnesium sulfate;
  • appendicitis;
  • rectal bleeding (including undiagnosed);
  • intestinal obstruction;
  • dehydration;
  • arterial hypotension;
  • depression of the respiratory center;
  • severe bradycardia;
  • AV blockade;
  • pre-natal period (2 hours before delivery).

 

Application in pregnancy and lactation

 

In pregnancy, Magnesia is used with caution, only in cases where the expected therapeutic effect exceeds the potential risk to the fetus.

 

If it is necessary to use lactation, breastfeeding should be discontinued.

 

special instructions

 

C with caution taken or administered parenterally with heart block, myocardial damage, chronic renal failure, respiratory diseases, acute inflammatory diseases of the digestive tract, pregnancy.

 

Magnesia can be used to relieve the status epilepticus (as part of complex treatment).

 

When an overdose causes CNS depression. As an antidote for an overdose of magnesium sulfate, calcium-calcium chloride or Calcium gluconate preparations are used.

 

Drug Interactions

 

With parenteral application of Magnesia and the simultaneous use of muscle relaxants of peripheral action, there is an intensification of the effects of muscle relaxants of peripheral action.

 

With the simultaneous ingestion of antibiotics from the Tetracycline group, the effect of tetracyclines may decrease due to a decrease in their absorption from the gastrointestinal tract.

 

A case of stopping breathing with the use of gentamycin in an infant with an elevated magnesium concentration in the blood plasma against the background of magnesium sulfate therapy is described.

 

At simultaneous application with Nifedipine the expressed muscular delicacy is possible.

 

Reduces the effectiveness of oral anticoagulants (including coumarin derivatives or derivatives of indanedione), cardiac glycosides, phenothiazines (especially chlorpromazine). Reduces the absorption of ciprofloxacin, etidronic acid, weakens the effects of streptomycin and tobramycin.

 

As an antidote for an overdose of Magnesia, calcium, calcium chloride or calcium gluconate preparations are used.

 

Pharmaceutically incompatible (precipitate forms) with preparations of Ca, ethanol (alcohol) (in high concentrations), carbonates, bicarbonates and phosphates of alkali metals, arsenic acid, barium, strontium, Clindamycin phosphate, Hydrocortisone sodium succinate, polymyxin In sulfate, procaine hydrochloride, salicylates and tartrates.

 

Analogues of medicinal product Magnesia

 

Structural analogs for the active substance:

  • Kormagnezin;
  • Magnesium sulfate;
  • Magnesium sulfate Darnitsa;
  • Magnesium sulfate solution for injection.

Similar medicines:

Other medicines:
Reviews (38):
Guests
Marina
As I remember about this drug - so start. It happened to me at 8 month of pregnancy to run about half a day on the building shops in search of tiles for the bathroom.I bought the tiles, but I was incredibly tired and went to the hospital in the evening to the maternity ward, because under the belly everything was very sore and strongly drawn. The verdict of a gynecologist is the threat of premature birth. Appointed a whole list of different drugs, of all I remember most of Magnesia. 4 hours, while Magnesia is being dripped, it is necessary to lie practically without movement. This is to punish me for a day's march-throw. It was lucky that one dropper was enough, no longer repeated. The effect, of course, weighty - to pull off, and the pain became less. Only without side effects did not happen - I wanted to drink as if I had not had a drink for a week. As a result, the pregnancy was saved and delivered safely. But, remembering the dropper with Magnesia, I did not overdo it anymore.
Guests
Mayan
I made it from a headache (intramuscularly). After severe stress, my head aches, it hurts for several days and nothing helps. She began to chop magnesium, the first three days three times a day (with bouts of pain), then only overnight. A week later the headaches passed.
Guests
Denis
Very good effective drug.
Guests
Tatyana
Decreases the pressure well.
Visitors
grandmother Larissa
By how much you can chop Magnesium in / m so no one in the instructions and does not write. You need to know!
Administrators
admin
grandmother LarissaIntramuscularly 25% magnesia is administered in a standard dosage of 10 ml (as much is contained in 1 ampoule, which facilitates the calculation of the solution administered). For intramuscular injection, the drug can not be diluted, intravenous injection shows dilution with saline or glucose.
Guests
incognita
A very good drug helps with asthma, I drank magnesia, it tastes terrible, but the effect is super. You will not go out from the toilet to build it. Health will be super. Who can, who can I advise!
Guests
Ella Nikolaevna
Has transferred or carried three infarcts of a brain. Until now, with headaches, I take magnesium, intramuscularly, symptomatically.
Guests
mulberry
I am now in the hospital, for the first time a system with magnesia was put. All day I run to the toilet in a small way. Displays excess fluid, the effect is kind of positive.
Guests
Olka
Well helped with constipation, and the last time zero. I drank it in the morning on an empty stomach, it is now 9 pm, and it did not turn out in the toilet with relief.
Guests
Gregory
It was at work. Pressure 180 to 120, made a prick of magnesia. Before the end of the shift, I participated well. At home the pressure died 140 to 90, this is my working pressure, it helped!
Guests
Tatyana
Tell me, does it help with gynecological diseases?
Administrators
admin
Tatyana, I do not know. I have not tried to give Magnesia to my patients in this capacity. There is also no indication in the instructions for this way of using the drug.
Guests
Alla
I hypotonic and I prescribed magnesium. From the first dropper there was vomiting a severe headache. From 2 droppers, a bradycardia pulse of 50-45 min., A pressure of 90 to 60. Not my drug.
Guests
Alla
With a severe headache, no medicine or tablets helped. I was afraid to prick magnesia and in vain, after the first injection in / m improvement went.
Guests
tatjna
I go to droppers. And the head is heavy. Does not pass. Made in / m magnesia and the head relaxed, I even took a nap, and the pressure did not change, a little increased. The prick was a little painful and the bump was, but I smeared it with a warming ointment and it all went away.
Guests
Nurgul
Hello. To my child 1 month. The child is restless and here 2 days cried for 4 hours without a stop, called an ambulance, took away and there they injected magnesium, after the child calmed down.
Guests
Sophia
My mother had high blood pressure 10/10, and the pressure rises even more. Then gave furosemide and again instead of coming down the pressure again rises, right up to 190 \ 110. I called the ambulance, urgently arrived and pricked magnesium and immediately went the process of lowering the pressure, with the word magnesia immediately helped.
Guests
Galina
At me an arterial hypertensia of 3 stages risk 4, there is a pressure zashkalivaet far for 200. I am helped or assisted by magnesia intravenously in an amount of 20 mg. The drug is very good, recommended for use for a long time.
Guests
Lyudmila
Very good drug. There was no strong headache.
Guests
valentine jarokhovich (ryabuhi)
After the introduction of intravenous magnesium, began to inject piracetam - pain to the shoulder joint pulling. From what? Can not it be that they did not dilute magnesium with saline solution?
Administrators
admin
valentine jarokhovich (ryabuhi)Was Magnesia used before? Perhaps this is your individual reaction to the use of the drug, a variant of the pain threshold. And intravenously (not drip), you can enter without dilution. Burning with this, of course, is present.

We can also assume an individual reaction of the injected drug with Piracetam, although there are usually no negative consequences when these medicines are used together.
Visitors
SvetlanaPat
Well, I generally have a different reaction to the drug magnesia! To begin with, that all life, and this is 54 years: vegetative-vascular dystonia, low blood pressure, tension headaches, increased nervousness and sensitivity as character traits, dullness and uncertainty. Valerian and motherwort are my regular drugs. There was an acute attack of cervical osteochondrosis, I could not get up from the bed for a week, twice as soon as I took off pain from pain. For the second week the neurologist prescribed magnesia intramuscularly. After the first injection, the investment of pain and most importantly! mental state and general health in spite of the pain is simply positive, joyful, I am full of strength and energy. This is unlike the condition after taking psychotropic and soothing drugs like Elenium and the like. And the panic was, and suddenly at me an intervertebral hernia? And what if it gets worse for me? And how can a child without me at the age of 14 cope independently with me lying? :)) A shot of magnesia - and the mood is excellent.
Guests
Tatyana
Hello. With LCD, can I take magnesium?
Administrators
admin
Tatyana, Magnesia when taken orally in the form of a suspension has a choleretic effect, so you can not take the drug with stones in the gallbladder. Stones can go along the ducts, there will come an obturation with all complications in the form of obstructive jaundice and other consequences.
Guests
love
Pricked injections intravenously at a very high pressure - it helped. And how many days can I take injections?
Administrators
admin
love, Magnesia is used to relieve hypertensive crises. Injection of this drug is a one-time manipulation. On a regular basis, the doctor must choose you antihypertensive therapy with pills for a long time, perhaps for life. Now for this there is a huge list of drugs for every taste and purse.
Guests
Lyudmila
The therapist appointed several drugs in / m and / in, including magnesium 5.0 № 10 (after the hypertensive crisis). I first take this drug and for me it seemed heavy (a strong heat inside, then nausea, etc.).I read that they do it once, but they appointed me for 10 days.
Guests
galena
Similarly ... Mom 86. Three days in a row the pressure of 240. The ambulance dibasol + magnesia. And now the therapist prescribed another 10 injections of magnesia.
Guests
Irina
My father (76 years old) had a pressure of 240 to 120 mm Hg. Art., he suffered a stroke 15 years ago. An ambulance was called. Father went himself, talked with us before the ambulance arrived. The ambulance injected magnesium intravenously. After 7 minutes he became worse before his eyes, began to sweat with a cold sweat, after 10 minutes. he died, the ambulance could not pump out. So decide whether the drug Magnesia is useful to everyone without exception? And no one is guilty either ...
Guests
Olga
My mom makes compresses on the joints with magnesium, says it helps with joint pain.
Guests
serega
Two days ago, at the wheel, I suddenly doubled in the eyes, I do not see the road, I can not go. Nothing hurts, heart does not pound. After about five minutes, my vision adjusted, neatly drove to the village hospital, the pressure was measured - 183/90. Have checked for a heart attack / stroke.Have stuck 5 cubes in a vein. First time in life. I barely stayed - the heat inside, my head became heavy - I asked for a couch. A couple of minutes, the heat rushed to his face. Even a rag soaked and on the forehead)) After a couple of minutes - came clarity, relief. Even would say - sleepiness. A little poznobilo. It helped. Despite the fact that until the end it did not introduce 5 dice, I noticed. And the weight is 105 / 190cm. Sergey 44g.
Guests
Akmaral. Kazakhstan
This drug comes from the Soviet era. And still in demand, then there's a sense.
Guests
Irina
At me vdd with astenovenovragennyj a syndrome. BP at 32 years went off to 180/110, rhythm 120, trembling in the body, headaches for months, which only did not appoint and calming the strong, and from the pressure. One doctor advised magnesia iv in 4 cubes and enalapril 5 mg. I pierced and felt immediately after the first injection of muscle relaxation, calmness and after this drug removed all soothing saws only enalapril, although the pressure was 130/90. After magnesia, seizures that recurred almost every day stopped, but before that I suffered 3 years. It is very happy with this preparation!
Visitors
Smurfetta
Hello. On the 12th week of pregnancy, I was sent to a hospital for preservation, since I was found to have a retrochoric hematoma with a threat of placental abruption and miscarriage. In the hospital, from the very first day, injections were given - intramuscular progesterone (1 ml), intramuscularly to transex (5 ml), intravenous glucose for the control of toxicosis, intramuscular magnesium (10 ml twice daily) and, as necessary, other drugs vitamins B6 and B12 intramuscularly, alternating every other day). All the shots that I received in the ass, were a sore, but especially painful prick, of course, was magnesia. In the first days of treatment, somehow it was tolerable, since it was necessary, so you need to endure, for the sake of the baby. The nurses got good, put the injections of magnesia neatly, slowly injecting the medicine, but nevertheless, on the third day, seals and bruises began to appear on my buttocks. My buttocks began to quickly turn into a sieve, it became painful to sit, I felt the aching from the injections round the clock, at night the pain also gave up in the leg from that side of the body on which you lay your side. I was already beginning to be scared by the sounds of the opening door to our room, and if a nurse with a 10-cubic-meter syringe in her hands appeared on the threshold,then my knees began to tremble, I wouldfully lay down on the bed, buried my face in the pillow, stripped off the fifth point and with fear awaited another painful injection of magnesia. Nurses treated us with sympathy before they pricked me, they asked me to relax the buttocks as much as possible, I tried to grope my finger on the buttock with the smallest cones and seals, and then only pierced the needle. By the end of the treatment, on the 10th day of my stay at the hospital, the injections in the ass became so unbearable that I was ready to scream with pain, especially when they put magnesia, but did nothing, managed it, for the sake of the health of my baby. When the nurse put me the last, 20th injection of magnesia, she said that magnesium preparations are the basis of treatment, they serve to relax the muscles of the uterus and remove the tone. Already at home, two weeks later, when my buttocks rested from the injections and there was a aching pain, I really appreciated and understood the whole benefit from the injections of magnesia.
Guests
Valya
I was given intravenously every other day. All winter sick, no drugs did not help, and after magnesia I felt better, the pressure normalized, the headaches moved away.It after the transferred or carried strokes.
Visitors
sergey1975
Hello, Doctor. I have a question for you, as an additional consultation. I have a diagnosis of intracranial hypertension, I'm sorry if I do not write correctly and high blood pressure. To me the doctor the therapist has appointed or nominated now Magnesium sulfate, a preparation old, but checked up, and so vascular, meksidol, nootropil, a cerebrolysin, on 5 ml. Can they be done in one day or in a day? Thank you.
Administrators
admin
sergey1975, I would do in a day, because too many injections will be in one day. But in the joint use of all the drugs mentioned in the question on the same day, there is nothing to worry about either, only administer the medication in different syringes and change the buttocks so that not all the injections will fall into one.

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