Calcium gluconate - instructions for use, analogs, reviews and release forms (tablets 500 mg, injections in ampoules for intramuscular and intravenous injections) of the drug for the treatment of hypocalcemia in adults, children and in pregnancy
In this article, you can read the instructions for using the drug Calcium gluconate. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Calcium gluconate in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Calcium gluconate in the presence of existing structural analogues.Use to treat osteoporosis and other forms of calcium deficiency in the body in adults, children, as well as during pregnancy and lactation.
Calcium gluconate - The calcium preparation replenishes the deficiency of calcium ions necessary for the process of nerve impulse transmission, reduction of skeletal and smooth muscles, myocardial activity, bone formation, and blood coagulation.
Calcium - a macronutrient involved in the formation of bone tissue, the process of blood coagulation, is necessary to maintain stable cardiac activity, the processes of transmission of nerve impulses. Improves muscle contraction in muscular dystrophy, myasthenia gravis, reduces vascular permeability. With intravenous administration of calcium causes the excitation of the sympathetic nervous system and increased adrenal secretion of the adrenal glands; has a moderate diuretic effect.
Pharmacokinetics
Approximately 1 / 5-1 / 3 part of the orally administered drug is absorbed into the small intestine; this process depends on the presence of vitamin D, pH, dietary characteristics and the presence of factors that can bind calcium ions.The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) is removed from the intestinal contents.
Indications
- diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), impaired conduction of nerve impulses in muscle tissue;
- hypoparathyroidism (latent tetany, osteoporosis), metabolic disorders of vitamin D: rickets (spasmophilia, osteomalacia), hyperphosphataemia in patients with chronic renal insufficiency;
- increased need for calcium ions (pregnancy, lactation period, period of increased body growth), insufficient calcium ions in food, a violation of its metabolism (in the postmenopausal period);
- increased excretion of calcium ions (prolonged bed rest, chronic diarrhea, secondary hypocalcemia, long-term use of diuretics and antiepileptic drugs, glucocorticosteroids);
- poisoning with salts of magnesium ions, oxalic and fluoric acids and their soluble salts (in the interaction with calcium gluconate insoluble and non-toxic calcium oxalate and calcium fluoride are formed);
- hypercalcemic form of paroxysmal myoplegia.
Forms of release
Tablets 500 mg
Tablets chewing 500 mg.
Solution for intravenous and intramuscular injection (injections) in ampoules of 100 mg / ml.
Instructions for use and dosage
Grind before consumption.
Inside, before meals or 1-1.5 hours after intake (squeezed milk). Adults - 1-3 g 2-3 times a day (the maximum daily dose - 9 g).
Pregnant and lactating mothers - 1-3 g 2-3 times a day (maximum daily dose - 9 g).
Children: 3-4 years - 1 g (maximum daily dose - 3.0 g); 5-6 years - 1-1.5 g (maximum daily dose - 4.5 g); 7-9 years - 1.5-2 g (the maximum daily dose - 6 g); 10-14 years - 2-3 g (the maximum daily dose - 9 g); the frequency of reception is 2-3 times a day.
With intravenous or intramuscular administration of calcium gluconate solution, a single dose of the drug should correspond to 2.25-4.5 mmol of calcium. Calcium chloride solution is given intravenously (slowly) in a single dose of 500 mg, iv dropwise in a single dose of 0.5-1 g.
Side effect
- constipation;
- irritation of the mucous membrane of the gastrointestinal tract;
- hypercalcemia.
Contraindications
- hypersensitivity;
- hypercalcemia (concentration of calcium ions should not exceed 12 mg%);
- severe hypercalciuria;
- nefrourolitiaz (calcium);
- propensity to thrombosis;
- sarcoidosis;
- simultaneous reception of cardiac glycosides (risk of arrhythmias);
- children under 3 years.
Application in pregnancy and lactation
The application is possible according to the dosing regimen.
special instructions
In patients with minor hypercalciuria, a decrease in glomerular filtration or with nephrourolythiasis in history, treatment should be controlled by the concentration of calcium ions in the urine.
Drinking plenty is recommended to reduce the risk of nephrourolythiasis.
Calcium gluconate is similar in effect to calcium chloride, but it has less irritating effect.
Drug Interactions
Forms insoluble complexes with antibiotics of the Tetracycline series (reduces the antibacterial effect).
With simultaneous application with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine.
Slows the absorption of tetracyclines, digoxin, oral iron preparations (the interval between their methods should be at least 2 hours).
When combined with thiazide diuretics can increase hypercalcemia.Reduces the effect of calcitonin in hypercalcemia. Reduces the bioavailability of phenytoin.
Analogues of the drug Calcium gluconate
Structural analogs for the active substance:
- Calcium gluconate B. Brown;
- Calcium gluconate is stabilized;
- Calcium gluconate-Vial;
- Calcium gluconate-lekT;
- Calcium gluconate injection 10%.
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