Dolobene - instructions for use, analogs, reviews and release forms (gel or ointment for external use) drugs for the treatment of bruises, bruises and injuries in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Dolobieni. The reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Dolobene in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Dolobene in the presence of existing structural analogues. Use to treat bruises, bruises and injuries in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Dolobieni - a combined preparation for external use. The effect of the drug is due to the active ingredients that make up its composition: Heparin sodium, dexpanthenol, dimethylsulfoxide.

Dimethyl sulfoxide has anti-inflammatory, anti-edematous and local analgesic effect. Anti-inflammatory activity is associated with some pharmacological effects, the most significant of which is the inactivation of hydroxyl radicals, which are produced in large quantities during the inflammation process and have a destructive effect on the tissue.

Dimethyl sulfoxide exerts a local analgesic effect by reducing the rate of nociceptive (painful) impulses in peripheral neurons. Anti-edematous action is provided by inactivation of hydroxyl radicals and improvement of subcutaneous metabolic reaction at the place of application of the drug. To a certain extent, the anti-edematous effect of dimethyl sulfoxide is due to its hygroscopic properties.

Dimethylsulfoxide (from 50% and more) penetrates through biological membranes, incl.through the skin, promoting better and deeper penetration into the tissues of other medicines used simultaneously with it.

Heparin has an anti-inflammatory effect, promotes the regeneration of connective tissue due to inhibition of hyaluronidase activity. Has a dose-dependent antithrombotic effect, increasing the inhibitory activity of antithrombin 3 on the activation of prothrombin and thrombin. Penetration of heparin through healthy skin is dose-dependent and is confirmed for a dose starting at 300 IU / g.

Dexpanthenol, when applied topically, is transformed into the skin into pantothenic acid (vitamin B). The efficacy of Dexpanthenol is comparable to that of pantothenic acid. Pantothenic acid as a component of coenzyme A participates in various catabolic and anabolic processes in tissues, due to the improvement of granulation and epithelization processes promotes the regeneration of damaged skin areas.

Composition

Heparin sodium + Dexpanthenol + Dimethyl sulfoxide, 10% H2O + auxiliary substances.

Pharmacokinetics

When using dimethylsulfoxide 1 g 3 times a day for 5 days, the average content of it at the site of application on the skin is 3 mg / g,the average content in the underlying muscular tissues and synovial membrane at the site of the synovial junction is 7-10 μg / ml, in the synovial fluid 0.8 μg / g. The concentration of dimethyl sulfoxide in blood plasma is 0.5 μg / g.

Heparin is absorbed slightly when applied externally.

With external use, dexpanthenol is transformed into the skin into pantothenic acid. Good absorption of dexpanthenol has been confirmed experimentally.

12-25% of absorbed dimethyl sulfoxide is excreted within the first 24 hours and 37-48% is excreted within 7 days unchanged by kidneys or in the form of metabolite (dimethylsulfone). 3.5-6% of total dimethyl sulfoxide is discharged through the lungs in the form of dimethyl sulfide 6-12 hours after application of the drug.

Indications

• edema, bruises (bruises) and inflammation of soft tissues, muscles, tendons, tendon sheaths;
• closed injuries, bruises;
• injuries of the joints with sprains and tendons;
• epicondylitis of the shoulder ("elbow of the tennis player"), tendinitis (tendon inflammation), tendovaginitis (inflammation of the tendon sheaths), bursitis (inflammation of the mucous bag of the joint);
• periarthritis of the shoulder joint;
• acute neuralgia.

Forms of release

Gel for external use (sometimes mistakenly called ointment or cream).

There are no other dosage forms, whether it's a pill or a solution.

Instructions for use and how to use them

Dolobien should be applied on the skin over the affected area of ​​the skin 2-4 times a day.

When using the gel under the bandage, apply the gel and wait a few minutes for it to be absorbed by the skin and evaporate the isopropanol. Then you can apply a sealed bandage.

Dolobene can be used for iontophoresis. The drug is applied to the cathode.

Dolobene as a contact gel can be used in ultrasound therapy (phonophoresis). The active substances of the gel complement the therapeutic effect of ultrasonic waves.

The duration of treatment depends on the severity of the symptoms and the severity of the disease.

Side effect

• possible skin reactions (redness, itching, burning sensation at the site of application of the gel), which usually disappear during further treatment;
• hives;
• angioedema;
• the smell of garlic from the mouth (caused by dimethyl sulfide, which is a product of the metabolism of dimethylsulfoxide);
• it is possible to change the taste sensations (disappear after a few minutes after applying the gel);
• nausea;
• diarrhea;
• difficulty breathing;
• headache;
• chills.

Contraindications

• severe violations of liver function;
• severe renal dysfunction;
• bronchial asthma;
• pronounced disorders of the cardiovascular system;
• open wounds at the site of application;
• pregnancy;
• lactation period;
• children under 5 years;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The use of the drug Dolobene is contraindicated in pregnancy due to the lack of data from clinical studies.

The use of Dolobene during breastfeeding is contraindicated, since dimethylsulfoxide is excreted in breast milk.

Use in children

Contraindicated for children under 5 years.

special instructions

Before applying Dolobene should thoroughly clean the skin of other medicines, cosmetics or any chemical agents.

Doloben can not be applied to the mucous membranes of the eyes, nose, mouth, open wounds or to damaged areas of the skin (due to irradiation, severe sunburn, post-operative scars).

During the treatment, the photosensitivity of the skin may be intensified,so during its use should limit the intense sunbathing and visits to the solarium.

In case of skin reactions, treatment should be discontinued.

Due to the high absorption of dimethylsulfoxide, do not use Dolobene in combination with other ointments and gels.

Drug Interactions

With a joint external application, Dolobene can enhance the penetration of other drugs through the skin.

With the simultaneous use of medicines containing sulindac (NSAIDs), the development of peripheral neuropathy is possible with the drug Dolobene.

Analogues of the drug Dolobene

Structural analogs for the active substance:

• Gepatrombin S.

Analogues for the pharmacological group (anticoagulants):

• Angioks;
• Angioflux;
• Anfiber;
• Arikstra;
• Acenocoumarol;
• Warfarex;
• Warfarin;
• Venabos;
• Venolife;
• Viatrom;
• Hemapaksan;
• Gepalpan;
• Heparin;
• Heparin ointment;
• Hepatrombin;
• Yellon gel;
• Calciparin;
• Clexan;
• Cleaver;
• Xarelto;
• Lavenum;
• Lyoton 1000;
• Marewan;
• Nigepan;
• Pelentan;
• Piyavit;
• Medical leech;
• Pradax;
• Seprotin;
• Cincumar;
• Skinlight;
• Trombleuss;
• Thrombophobia;
• Troparin;
• Phenylin;
• Fragmin;
• Fraksiparin;
• Fraksiparin Forte;
• Cibor;
• EXPANT SK;
• Eliwis;
• Emeran;
• Essaven.

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