Allokin alfa - instructions for use, reviews, analogues and forms of injection (injections in ampoules for injections № 1,2,3,4,5,6,10 and 20) drugs for the treatment of papillomas, herpes and hepatitis B in adults, children and during pregnancy. Interaction with alcohol

In this article, you can read the instructions for using the drug Allokin alfa. There are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Allokin alfa in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogs Allokin alfa in the presence of existing structural analogues.Use for the treatment of papillomas, herpes and hepatitis B in adults, children, as well as during pregnancy and lactation. Interaction with alcohol.

Allokin alfa - is an oligopeptide. By the nature of the pharmacological action is most similar to Interferon alpha. Alloferon (the active substance of the drug Allokin alfa) is an effective inducer of the synthesis of endogenous interferons and the activator of the natural killer system, it is capable of stimulating the recognition and lysis of defective cells by cytotoxic lymphocytes. The experiments demonstrated high efficiency in relation to infections caused by influenza A and B viruses, hepatitis B and C, herpes of type 1 and type 2 and human papilloma. Alloferon does not have general toxicity, allergenic properties, mutagenic and carcinogenic effects, does not have embryotoxic effect and does not affect reproductive function.

Composition

Histidyl-glycyl-valyl-seryl-glycyl-histidyl-glycyl-glutaminyl-histidyl-glycyl-valyl-histidyl-glycine (Alloferon) + auxiliary substances.

Pharmacokinetics

Quickly penetrates into the blood, where it interacts with immunocompetent cells,after which the determination of the concentration of alloferon is hampered by the close structural similarity of its metabolites to serum proteins. The increase in the concentration of interferon was noted 2 hours after the administration of the drug and remained at a high level (2-2.5 times higher than the usual background) for 6-8 hours with the achievement of the baseline values ​​by the end of the day. Increased functional activity of natural killers was observed within 7 days after drug administration.

Indications

• a chronic papillomavirus infection caused by oncogenic human papillomaviruses;
• chronic recurrent herpes of types 1 and 2;
• in the complex therapy of the moderate (icterus) form of acute hepatitis B.

Forms of release

Lyophilizate for solution for injection (injections in ampoules) № 1,2,3,4,5,6,10 and 20 pieces per package.

Instructions for use and dosing regimen

The drug is administered subcutaneously.

The standard course of treatment for infections caused by oncogenic types of human papillomavirus includes injections of the drug at a dose of 1 mg every other day, total for a course of 6 injections.

The standard course of treatment for recurrence of herpes involves injecting the drug at a dose of 1 mg every other day, total for a course of 3 injections.

For moderate forms of acute hepatitis B, the drug is administered after verification of the diagnosis at a dose of 1 mg 3 times a week for 3 weeks (9 injections in total).

To prepare a solution for injection as a solvent, use 1 ml of a 0.9% solution of sodium chloride.

Side effect

• weakness;
• dizziness;
• the formation of new elements of the rash (with herpetic infection).

Contraindications

• pregnancy and breastfeeding (at the time of treatment, discontinue);
• expressed autoimmune diseases;
• childhood;
• hypersensitivity.

Application in pregnancy and lactation

Contraindicated in pregnancy and lactation.

Use in children

Contraindicated in children.

special instructions

In monotherapy Allokin-alpha is recommended for the treatment of papillomavirus infection caused by oncogenic types of the virus, in the absence of clinical and subclinical lesions of the cervix and anogenital region.

As part of complex therapy - for the treatment of clinical and subclinical forms of cervical and anogenital lesions by papillomavirus infection caused by oncogenic types of the virus.

Treatment of chronic recurrent herpes of types 1 and 2 is recommended to begin when the earliest signs of the disease appear.

With hepatitis B - no later than the 7th day after the onset of jaundice.

Impact on the ability to drive and work with machinery

If there is dizziness, you need to refrain from driving and working with machinery.

Drug Interactions

In the treatment of chronic recurrent genital herpes can be prescribed in combination with Acyclovir and its derivatives (the drugs have a different mechanism of action and complement each other in the treatment of viral infection).

In acute hepatitis B, the drug is prescribed against the background of conventional basal therapy.

Interaction with other drugs, including with ethanol (alcohol) is not revealed.

Analogues of the drug Allokin alpha

Structural analogs for the active substance:

• Alloferon.

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