Buscopan - instructions for use, analogs, testimonials and release forms (rectal suppositories 10 mg, tablets 10 mg) of a drug for the treatment of renal and biliary colic in adults, children and pregnancy

In this article, you can read the instructions for using the drug Buscopan. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Buskopan in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Buskopan in the presence of existing structural analogues. Use for the treatment of renal and biliary colic in adults, children, as well as during pregnancy and lactation.

Buscopan - blocker of m-holinoretseptorov. Has a local spasmolytic effect on the smooth muscles of the internal organs (digestive tract, bile ducts, urinary tract), reduces the secretion of digestive glands. Local spasmolytic effect is explained by ganglion blocking and m-cholinoblocking activity of the drug.

Being a quaternary ammonium derivative, hyoscine butyl bromide (the active substance of the preparation Buskopan) does not penetrate the blood-brain barrier (BBB), therefore, there is no anticholinergic effect on the CNS.

Composition

Hyoscine butyl bromide + excipients.

Pharmacokinetics

Being a quaternary ammonium derivative and having a high polarity, hyoscine butyl bromide is slightly absorbed into the digestive tract. After application, the absorption of the drug is 8%. The average absolute bioavailability is less than 1%. Hyoscine butyl bromide, due to its high affinity for m- and n-cholinergic receptors, is mainly distributed in the muscle cells of the abdominal and pelvic organs, as well as in the intramural ganglia of the abdominal organs. After oral administration of the drug occurs with feces and urine.

Indications

• renal colic;
• biliary colic;
• spastic dyskinesia of the bile duct and gall bladder;
• cholecystitis;
• intestinal colic;
• pilorospasm;
• peptic ulcer of the stomach and duodenum in the phase of exacerbation (as part of complex therapy);
• algodismenorea.

Forms of release

The tablets covered with a cover of 10 mg.

Candles rectal 10 mg.

Other forms of the drug, whether syrup, solution in ampoules or vaginal candles at the time of publication did not exist.

Instructions for use and reception scheme

Pills

Adults and children over 6 years of age are prescribed 1-2 tablets 3-5 times a day.

Tablets should be taken orally, with water.

The drug should not be used daily for more than 3 days without consulting a doctor.

Candles

Rectally 1-2 candles 3 times a day. The duration of treatment is determined by the doctor.

The suppository is introduced into the rectum with a pointed end forward.

Side effect

• dry mouth;
• dry skin;
• tachycardia;
• retention of urine;
• cutaneous manifestations;
• anaphylaxis with episodes of shortness of breath;
• anaphylactic shock;
• anaphylactic reactions;
• dyspnea;
• skin reactions (eg, urticaria, rash, erythema, pruritus);
• dyshidrotic eczema.

Contraindications

• myasthenia gravis;
• megacolon;
• children's age till 6 years;
• pregnancy;
• lactation period;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Data on the use of the drug in pregnancy and on the penetration of the drug and its metabolites into breast milk are limited.

Studies on the effect of the drug on fertility have not been conducted.

As a precaution, the use of the drug during pregnancy and during lactation is not recommended.

special instructions

Caution should be given to the drug in the following clinical situations: suspicion of intestinal obstruction (including stenosis of the pylorus); obstruction of the urinary tract (including benign prostatic hyperplasia), tachyarrhythmias (including ciliary tachyarrhythmia), angle-closure glaucoma.

In cases where abdominal pain of unknown origin persists or worsens, or when symptoms such as fever, nausea, vomiting, changes in stool consistency and frequency of stool, sensitivity of the abdomen, a decrease in blood pressure, fainting or feces occur simultaneously, it is necessary to immediately consult for medical advice.

It is unclear the based hearing about the use of Buscopan for relaxing the smooth muscles of the uterine cervix during labor and during the final trimester of pregnancy. The lack of proof of this statement by clinical studies requires special caution in the appointment.

Impact on the ability to drive vehicles and manage mechanisms

Studies on the effect of the drug on the ability to drive vehicles and control mechanisms have not been conducted.

Drug Interactions

Buscopan can enhance the anticholinergic effect of tricyclic and tetracyclic antidepressants, antihistamines, antipsychotics, quinidine, amantadine, disopyramide, anticholinergics (eg, tiotropium bromide, ipratropium bromide, atropine-like compounds).

Simultaneous application of Buscopan and dopamine antagonists (for example, metoclopramide) results in a weakening of the action on the gastrointestinal tract of both drugs.

Buscopan can enhance tachycardia caused by beta-adrenomimetics.

Analogues of the drug Buscupan

Buskopan does not have a structural analogue for the active substance.

Analogues for the pharmacological group (m-cholinolytics):

• Atrovent;
• Atropine;
• Vesicar;
• Gastrozem;
• Gastrotsepin;
• Glypine;
• Detruzitol;
• Driptan;
• Ipravent;
• Ipratropium Steri Neb;
• Orlovs extract;
• Metacin;
• Midratsil;
• Midrim;
• Novitropane;
• Oxybutine;
• Pyrene;
• Pitophenone hydrochloride;
• Platyphylline;
• Riabal;
• Rolitan;
• Spazmeks;
• Spiriva;
• Trigan;
• Tropicamide;
• Truvent;
• Urotol;
• Fenpiverinia bromide;
• Cyclosyl;
• Cyclomed;
• Cycloptic;
• Cystrin.

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