Platifillin - instructions for use, analogs, reviews and release forms (5 mg tablets, including papaverine, injections in ampoules for injection in solution) medications for the treatment of spasms and colic in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Platyphylline. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Platifillin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Platifillin analogues in the presence of existing structural analogues.Use to treat spasms and colic in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Platyphylline - blocker of m-holinoretseptorov. In comparison with atropine has a less pronounced effect on peripheral m-holinoretseptory (the effect on the smooth muscle cells of the gastrointestinal tract and the circular muscle of the iris is 5-10 times weaker than atropine). Blocking m-holinoretseptory, violates the transmission of nerve impulses from postganglionic cholinergic nerves to the effector organs and tissues innervated by them (heart, smooth muscle organs, external secretion glands); suppresses also n-holinoretseptory (much weaker). Holin-blocking effect is more pronounced against a background of increased tone of the parasympathetic part of the autonomic nervous system or the action of m-cholinostimulators.

To a lesser extent than atropine, causes tachycardia, especially when used in high doses. Decreasing the effect of n.vagus, improves the conductivity of the heart, increases the excitability of the myocardium, increases the minute volume. It has a direct myotropic antispasmodic effect, causes the expansion of small vessels of the skin.In high doses, the vasomotor center depresses and blocks sympathetic ganglia, as a result of which vessels dilate and blood pressure decreases (mainly with intravenous administration). Weaker atropine depresses the secretion of endocrine glands; causes a marked decrease in the tone of smooth muscles, the amplitude and frequency of peristaltic contractions of the stomach, duodenum, small and large intestine, a moderate decrease in the tone of the gallbladder (in persons with hyperkinesia of bile ducts); at a hypokinesia - a tonus of a cholic bubble raises or increases up to a normal status. It causes relaxation of the smooth muscles of the uterus, bladder and urinary tract; providing spasmolytic action, eliminates pain syndrome. Relaxes the smooth musculature of the bronchi, caused by an increase in the tone of n.vagus or holinostimuljatorami, increases the volume of breathing, inhibits the secretion of the bronchial glands; reduces the tone of sphincters.

When instilled into the conjunctival sac of the eye and parenteral administration, the pupil dilates due to relaxation of the circular muscle of the iris. At the same time, the intraocular pressure rises and paralysis of accommodation sets in (ciliary muscle relaxationciliary body). In comparison with atropine, the effect on accommodation is less and shorter. Excites the brain and respiratory center, mostly - the spinal cord (in high doses, cramps, CNS depression, vasomotor and respiratory centers are possible). Penetrates through the blood-brain barrier (BBB).

Papaverine is an antispasmodic agent that has an antihypertensive effect. It inhibits PDE, lowers tone and relaxes the smooth muscles of internal organs (GIT, respiratory and genitourinary system) and vessels.

Composition

Platifillina hydrotartrate + auxiliary substances.

Platifillina hydrotartrate + Papaverine hydrochloride + excipients.

Pharmacokinetics

After oral administration, it is well absorbed from the digestive tract. It is subjected to hydrolysis with the formation of platinetsin and platinetic acid.

Indications

Spasm of smooth muscles:

• abdominal cavity organs (cholecystitis, pilorospasm, spastic colitis, cholelithiasis, intestinal colic, renal colic, biliary colic);
• vessels of the brain;
• endarteritis;
• angina pectoris (as part of complex therapy);
• bronchospasm;
• peptic ulcer of the stomach and duodenum.

Expansion of the pupil with a diagnostic purpose (incl.examination of the fundus, determination of the true refraction of the eye); acute inflammatory diseases of the eyes (including iritis, iridocyclitis, keratitis), eye trauma.

Forms of release

Solution for subcutaneous injection (injections in ampoules for injection).

Tablets 5 mg (including with papaverine).

Instructions for use and dosage

Applied internally, parenterally (subcutaneously), rectally, topically in ophthalmology.

Subcutaneously - 2-4 mg 3 times a day. The highest single dose - 10 mg, daily - 30 mg.

Pills

Inside, 1 tablet 2-3 times a day.

Side effect

• dry mouth;
• thirst;
• intestinal atony;
• a decrease in blood pressure;
• tachycardia;
• CNS excitation;
• dizziness;
• dilated pupils;
• paralysis of accommodation;
• headache;
• photophobia;
• convulsions;
• acute psychosis;
• difficulty urinating;
• retention of urine;
• atelectasis of the lung.

Contraindications

• hypersensitivity to platyphylline.

Application in pregnancy and lactation

Data on the safety of platyphylline during pregnancy and lactation (breastfeeding) are not available.

Use in children

Use with caution in chronic lung diseases in young children (reduced bronchialsecretion can lead to a thickening of the secret and the formation of congestion in the bronchi); brain damage in children (effects from the central nervous system may be intensified); Down's disease (perhaps unusual dilated pupils and an increase in heart rate), cerebral palsy (response to anticholinergics may be most pronounced).

special instructions

C use caution in patients with diseases of the cardiovascular system, in which an increase in heart rate may be undesirable:

• atrial fibrillation, tachycardia, chronic heart failure, IHD, mitral stenosis, arterial hypertension, acute bleeding;
• with thyrotoxicosis (tachycardia may be increased);

and:

• elevated temperature (may still increase due to suppression of the activity of sweat glands);
• in reflux esophagitis, hiatal hernia, combined with the reflux oesophagitis (decreased motility of the esophagus and stomach and lower esophageal sphincter relaxation may help slow gastric emptying and increased gastroesophageal reflux through sphincter with impaired function);
• with gastrointestinal diseases accompanied by obstruction - achalasia of the esophagus, stenosis of the pylorus (there may be a decrease in motor and tone, leading to obstruction and retention of the contents of the stomach), intestinal atony in elderly patients or weakened patients (possible obstruction), paralytic ileus;
• when the intraocular pressure rises, a closed-angle (mydriatic effect, leading to an increase in intraocular pressure, can cause an acute attack) and open-angle glaucoma (mydriatic effect may cause some increase in intraocular pressure and may require correction of therapy);
• with nonspecific ulcerative colitis (high doses can inhibit intestinal peristalsis, increasing the probability of paralytic intestinal obstruction, in addition, manifestation or exacerbation of such a serious complication as a toxic megacolon);
• when dry in the mouth (prolonged use may cause a further increase in the severity of xerostomia);
• with hepatic insufficiency (decreased metabolism) and renal failure (risk of side effects due to reduced excretion);
• with chronic lung diseases, especially in young children and weakened patients (a decrease in bronchial secretion can lead to a thickening of the secret and the formation of congestion in the bronchi);
• with myasthenia gravis (the condition may worsen due to inhibition of the action of acetylcholine);
• hypertrophy of the prostate without obstruction of the urinary tract, urinary retention or predisposition to it or diseases accompanied by urinary tract obstruction (including the bladder neck due to prostatic hypertrophy);
• at gestosis (hypertension is possible);
• brain damage in children (effects from the central nervous system may be intensified);
• Down's disease (perhaps unusual dilated pupils and an increase in heart rate), cerebral palsy (response to anticholinergics may be most pronounced).

Impact on the ability to drive vehicles and manage mechanisms

It is necessary to refrain from potentially dangerous activities requiring increased attention and speed of psychomotor reactions.

Drug Interactions

With simultaneous use with Haloperidol in patients with schizophrenia may reduce the antipsychotic effect.

Platifillin is a proserin antagonist.

With simultaneous use, the duration of the hypnotics of phenobarbital, ethaminal sodium, magnesium sulfate increases.

When applied simultaneously with the other m-holinoblokatorami, as well as drugs having m-anticholinergic activity (including amantadine, haloperidol, phenothiazines, MAO inhibitors, tricyclic antidepressants, some antihistamines) increases the risk of side effects.

Morphine increases the inhibitory effect of platyphylline on the cardiovascular system.

When used simultaneously with MAO inhibitors, a positive chrono- and batmotropic effect is observed; with cardiac glycosides - a positive butmotropic effect.

When the pain associated with spasms of smooth muscles, the action platifillina strengthen analgesics, sedatives, and anxiolytics, vascular spasm - hypotensive and sedative.

Papaverine reduces the effect of methyldopa.

Analogues of the drug Platifylline

Structural analogs for the active substance:

• Platifillin hydrotartrate.

Analogues on the pharmacological group (antispasmodics):

• Avisan;
• Altalex;
• Andipal;
• Bendazole;
• Galidor;
• Dibazol;
• Dicetel;
• Driptan;
• Droverin;
• Drotaverine;
• Duspatalin;
• Kellin;
• Librax;
• Niaspam;
• Nikoshpan;
• But the spine;
• But the forte;
• But-shpalgin;
• Novitropane;
• Nomigren;
• Oxybutine;
• Papaverine;
• Pape;
• Plantex;
• Platyphylline with papaverine;
• Ple-Spa;
• Candles with papaverine hydrochloride;
• Spazmoveralgin Neo;
• Spazmol;
• Spasmodic;
• Spasmonet;
• Spasmonet forte;
• Spasmocystenal;
• Cosporeine;
• Spacock;
• Sparex;
• Theodibaverin;
• Trigan;
• Urolesan;
• Cystenal;
• Cystrin;
• Enablex;
• Yunispaz.

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