Ceforol solute - instruction on the use of antibiotic, reviews, analogs and forms of release (tablets 400 mg) drugs for the treatment of bronchitis, cystitis and gonorrhea in adults, children and pregnancy

In this article, you can read the instructions for using the drug Ceforal solutab. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of antibiotic Ceforal solute in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ceforal soluteba in the presence of existing structural analogues. Use for the treatment of bronchitis, cystitis and gonorrhea in adults, children, as well as during pregnancy and lactation.

Ceforal solutab - semisynthetic antibiotic from the group of cephalosporins of the 3rd generation for oral administration. Has a bactericidal effect. The mechanism of action is associated with the inhibition of bacterial cell wall synthesis. Cefixime is resistant to the action of broad-spectrum beta-lactamases produced by many Gram-positive and Gram-negative bacteria.

In clinical practice, the efficacy of cefixime has been confirmed in infections caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.

Cefixime is also active against Gram-positive - Streptococcus agalactiae and Gram-negative bacteria - Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus.

The drug is resistant to Pseudomonas spp., Enterococcus spp., Listeria monocytogenes, most strains Enterobacter spp., Staphylococcus spp. (including methicillin-resistant strains), Bacteroides fragilis, Clostridium spp.

Composition

Cefaxime trihydrate + excipients.

Pharmacokinetics

When administered, the bioavailability is 40-50% and does not depend on food intake. About 65% of ceficimin binds to plasma proteins. The highest concentrations of cefixime create in the urine and bile. Cefixime penetrates the placenta. In breast milk, the drug is not determined. Cefixime is not metabolized in the liver; 50-55% of the accepted dose is excreted unchanged in urine within 24 hours.About 10% of cefixime is excreted with bile.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to the preparation:

• Streptococcal tonsillitis (tonsillitis) and pharyngitis;
• sinusitis;
• acute bronchitis;
• exacerbation of chronic bronchitis;
• acute otitis media;
• uncomplicated urinary tract infections (cystitis, pyelonephritis);
• uncomplicated gonorrhea;
• shigellosis.

Forms of release

Tablets are dispersible 400 mg.

Instructions for use and dosing regimen

For adults and children with a body weight of more than 50 kg, the daily dose is 400 mg in 1 or 2 divided doses.

Children with a body weight of 25-50 kg of the drug is administered at a dose of 200 mg per day in a single dose.

The tablet can be swallowed by washing with a sufficient amount of water, or diluted in water and drunk the resulting suspension immediately after preparation. The drug can be taken regardless of food intake.

The duration of treatment depends on the nature of the course of the disease and the type of infection. After the disappearance of the symptoms of infection and / or fever, it is advisable to continue taking the drug for at least 48-72 hours.

The course of treatment for respiratory tract infections and ENT organs is 7-14 days.

With tonsillofaringitis caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days.

With uncomplicated gonorrhea, the drug is prescribed at a dose of 400 mg once.

In uncomplicated infections of the lower urinary tract in women, the drug is prescribed for 3-7 days, with uncomplicated upper urinary tract infections in women - within 14 days.

In uncomplicated infections of the upper and lower urinary tract in men, the duration of treatment is 7-14 days.

Side effect

• transient leukopenia, agranulocytosis, pancytopenia, hemolytic anemia, thrombocytopenia or eosinophilia;
• blood clotting disorders;
• hives;
• itching;
• Lyell's syndrome (in this case the drug should be immediately canceled);
• drug fever;
• interstitial nephritis;
• headache;
• dizziness;
• dysphoria;
• stomach ache;
• digestive disorders;
• nausea, vomiting;
• diarrhea;
• pseudomembranous colitis;
• hematuria.

Contraindications

• increased sensitivity to cephalosporins or penicillins;
• hypersensitivity to cefixime or the components of the drug.

Application in pregnancy and lactation

The use of the drug Ceforal Solutab during pregnancy is possible in the event that the intended use for the mother exceeds the potential risk to the fetus.

If it is necessary to use the drug during lactation, breastfeeding should be temporarily stopped.

special instructions

In connection with the possibility of the occurrence of cross-allergic reactions with penicillins, it is recommended to carefully evaluate the patient's history. If an allergic reaction occurs, the drug should be discontinued immediately.

With prolonged use of the drug, it is possible to disrupt the normal intestinal microflora, which can lead to excessive reproduction of Clostridium difficile and the development of pseudomembranous colitis. When light forms of antibiotic-associated diarrhea appear, it is usually enough to stop taking the drug. In more severe forms, a corrective treatment is recommended (for example, administration of Vancomycin orally 250 mg 4 times per day). Antidiarrhoeal drugs that inhibit gastrointestinal motility are contraindicated in the development of pseudomembranous colitis.

In the case of the use of the drug Ceforal Solutab concomitantly with aminoglycosides, polymyxin B, sodium colistimetate,"loop" diuretics (furosemide, ethacrynic acid) in high doses, it is necessary to closely monitor the kidney function. After a long treatment with Cephorol Solutab, the condition of the hematopoietic function should be checked.

Dispersible tablets should be dissolved only in water.

During treatment, a false positive Coombs reaction and a false positive urine reaction to glucose are possible with some test systems for express diagnostics.

Impact on the ability to drive vehicles and manage mechanisms

Studies of the effect of Ceforal Solutab on the ability to drive vehicles and mechanisms have not been carried out. Due to possible adverse effects (eg, dizziness), care should be taken.

Drug Interactions

The tubular secretion blockers (including probenecid) slow the excretion of cefixime in the urine, which can lead to overdose symptoms.

Ceforal soluteab reduces the prothrombin index, increases the effect of indirect anticoagulants.

With the simultaneous use of cefixime withcarbamazepine, an increase in plasma concentration was observed; in such cases it is advisable to carry out therapeutic drug monitoring.

Analogues of the drug Ceforal solute

Structural analogs for the active substance:

• Ixim Lupine;
• Panzef;
• Supraks;
• Cemidexor;
• Cefspan.

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