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Cefalexin - instructions for use, reviews, analogs and forms of release (capsules and tablets 250 mg and 500 mg, granules or powder for the preparation of a suspension or syrup) of an antibiotic preparation for the treatment of infections in adults, children and pregnancy

Cefalexin - instructions for use, reviews, analogs and forms of release (capsules and tablets 250 mg and 500 mg, granules or powder for the preparation of a suspension or syrup) of an antibiotic preparation for the treatment of infections in adults, children and pregnancy

In this article, you can read the instructions for using the drug Cephalexin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of antibiotic Cephalexin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cefalexin in the presence of existing structural analogues.Use for the treatment of infectious diseases (pneumonia, bronchitis, tonsillitis) in adults, children, as well as during pregnancy and lactation. Interaction of the drug with alcohol.

 

Cephalexin - 1 generation cephalosporin antibiotic. It acts bactericidal, disrupts the synthesis of the cell wall of microorganisms. Resistant to lactamases.

 

Has a wide range of activities. It is active against gram-positive microorganisms - Staphylococcus spp., (Including penicillinase-producing and non-producing penicillinase strains Staphylococcus aureus, penicillin-sensitive strains of Staphylococcus epidermidis), Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes), Corynebacterium diphtheriae; Gram-negative microorganisms - Neisseria meningitidis, Neisseria gonorrhoeae, Shigella spp., Salmonella spp., Escherichia coli, Klebsiella spp. (including Klebsiella pneumoniae), Moraxella catarrhalis, Proteus mirabilis; Treponema spp., Radiant fungi.

 

Ineffective against Pseudomonas aeruginosa, Proteus spp. (indolpositive strains), Morganella morganii, Mycobacterium tuberculosis, Enterococcus faecalis, Haemophilus spp., Enterobacter spp., Serratia spp., Pseudomonas spp., Aeromonas spp., Acinetobacter spp., methicillin-resistant strains, anaerobic microorganisms.

 

It is resistant to penicillinase of staphylococci, but is destroyed by cephalosporinase of gram-negative microorganisms.

 

Composition

 

Cefalexin monohydrate + excipients.

 

Pharmacokinetics

 

After ingestion quickly and well absorbed. Bioavailability is 90-95%, food intake slows down absorption, but does not affect its completeness.The therapeutic concentration persists for 4-6 hours. It is distributed relatively evenly in various tissues and body fluids: lungs, liver, heart, kidneys, bile, gall bladder, bones, joints, respiratory tract. Poorly penetrates the unchanged blood-brain barrier (BBB). Passes through the placenta, in small amounts excreted in breast milk, is found in the amniotic fluid. It is not metabolized. It is excreted by the kidneys - 70-89% unchanged (2/3 - glomerular filtration, 1/3 - tubular secretion); with bile - 0.5%.

 

Indications

  • upper and lower respiratory tract infections (pharyngitis, otitis media, sinusitis, tonsillitis, bronchitis, acute and exacerbation of chronic pneumonia, bronchopneumonia, empyema and lung abscess);
  • infection of the genitourinary system (pyelonephritis, cystitis, urethritis, prostatitis, epididymitis, endometritis, gonorrhea, vulvovaginitis);
  • infections of the skin and soft tissues (furunculosis, abscess, phlegmon, pyoderma, lymphadenitis, lymphangitis);
  • infection of bones and joints (including osteomyelitis).

 

Forms of release

 

The tablets covered with a cover of 250 mg.

 

Capsules 250 mg and 500 mg.

 

Powder for the preparation of a suspension for ingestion 125 mg, 250 mg and 500 mg. Suspension is sometimes mistakenly termed syrup.

 

Granules for suspension for oral administration 250 mg.

 

There are no other forms, including injections in the form of injections.

 

Instructions for use and dosage

 

Tablets, capsules and granules

 

Inside, 30-60 minutes before meals, washed down with water.

 

The average dose for adults and children over 10 years is 250-500 mg every 6 hours. The daily dose of the drug should be at least 1-2 g, if necessary, can be increased to 4 g. The duration of the course of treatment is 7-14 days. For infections caused by group A beta-hemolytic streptococcus, the minimum duration of treatment is 10 days.

 

Children up to 10 years of age, the drug is recommended to be administered in the form of a suspension for oral administration. With a body weight of less than 40 kg, the average daily dose is 25-100 mg / kg body weight; the frequency of reception is 4 times a day. With average otitis - a dose of 75 mg / kg /, the frequency of reception - 4 times a day. With streptococcal pharyngitis, infections of the skin and soft tissues, the frequency of reception is 2 times a day. In severe infections, the daily dose can be increased to 100 mg / kg of body weight, and the frequency of intake - up to 6 times a day.

 

Preparation of the suspension: in the vial add water to the risks and shake well.The prepared suspension is stable at room temperature for 14 days. Before each use, the suspension must be shaken. 5 ml of the finished suspension contains 250 mg of cephalexin.

 

Powder for the preparation of suspension

 

When prescribing the drug, children are recommended to follow the following scheme:

  • up to 1 year (body weight up to 10 kg) - 0.5 g;
  • from 1 to 6 years - 0.5-1 g;
  • from 6 to 10 years - 1 g;
  • from 10 years to 14 years - 1-2 g.

 

Rules for the preparation of suspension

 

To prepare the suspension, add 80 ml of distilled water to a vial containing 2.5 g of the preparation. In 1 ml of the finished suspension contains 25 mg of cephalexin. Dosage the suspension with a special spoon with two marks: the lower one corresponds to 2.5 ml (62.5 mg) and the upper one - 5 ml (125 mg). Shake the bottle before use.

 

Side effect

  • rash;
  • hives;
  • angioedema;
  • erythema;
  • eosinophilia;
  • toxic epidermal necrolysis;
  • Stevens-Johnson syndrome;
  • anaphylactic shock;
  • pain in the abdomen;
  • dry mouth;
  • anorexia;
  • nausea, vomiting;
  • diarrhea;
  • Candidiasis of the intestine, oral cavity;
  • pseudomembranous enterocolitis;
  • dizziness;
  • weakness;
  • headache;
  • excitation;
  • hallucinations;
  • convulsions;
  • interstitial nephritis;
  • itching of the genitals and anus;
  • vaginitis;
  • vaginal discharge;
  • candidiasis of genital organs;
  • leukopenia, neutropenia, thrombocytopenia;
  • arthralgia.

 

Contraindications

  • Children under 3 years of age (for a dosage form - capsules);
  • hypersensitivity (including to other beta-lactam antibiotics).

 

Application in pregnancy and lactation

 

The use of the drug during pregnancy and during lactation is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

 

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

 

Use in children

 

Contraindicated the use of capsules in children under the age of 3 years. Children up to 10 years of age, the drug is recommended to be administered in the form of a suspension for oral administration.

 

special instructions

 

Patients with allergic reactions to penicillins and carbapenems in history may have increased sensitivity to cephalosporin antibiotics.

 

During treatment with cephalexin, a positive direct Coombs reaction is possible, as well as a false positive urine reaction to glucose.

 

During the treatment it is not recommended to use ethanol (alcohol).

 

In patients with impaired renal function, cumulation is possible (correction of the dosing regimen is required).

 

With staphylococcal infection, there is a cross-resistance between cephalosporins and isoxazolylpenicillins.

 

Drug Interactions

 

When used simultaneously with furosemide, ethacrynic acid, nephrotoxic antibiotics (eg, aminoglycosides), the risk of kidney damage increases.

 

Salicylates and Indomethacin slow the excretion of cephalexin.

 

Cefalexin reduces the prothrombin index, increases the effect of indirect anticoagulants.

 

Analogues of the drug Cephalexin

 

Structural analogs for the active substance:

  • Ceflex;
  • Opexin;
  • Palitrex;
  • Piassan;
  • Soleksin;
  • Soleksin Forte;
  • Felaxin;
  • Cefaklen;
  • Cephalexin AKOS;
  • Cef;
  • Ecocephron.

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Reviews (44):
Guests
Ioannina
I know that many people consider antibiotics a panacea for all diseases and grab for them with the slightest sneeze even without the appointment of a doctor. I, on the contrary, treat them prejudiced and never accepted them. If possible, I tried to treat children either with folk remedies, or with other medicines that are not so potent. But last summer still had to resort to the help of one of the antibiotic drugs - cephalexin.

The younger son had been fishing with his father for several days on fishing, they returned both cooled down, I foamed their feet, drank tea with lemon and honey, dried mustard in socks - and slept. And at night both have a temperature under 40, called an ambulance, the doctor diagnosed angina and prescribed cephalexin. I pay tribute to this antibiotic - I put my husband and son to my feet for 4 days (my husband drank pills, my son - a suspension). Thank God, no one had any allergic reactions and intolerance, although they did not manage to avoid diarrhea. In general, I think that the drug coped with its task successfully, although I remain at my opinion: antibiotics are created only for extreme cases and, if possible, better do without them.
Guests
Irina
I have a question. My daughter is 3 years old. Cough, very strong, sore throat. Assigned cephalexin 250 ml 3 r per day. Is it possible for my daughter? Is it not harmful? After all, an antibiotic? And is it possible to take amoxiclav instead? What is their difference? Thank you!!!!
Administrators
admin
Irina, Cefalexin can be given to children. Amoxiclav is another antibiotic according to the active ingredient. Accept the one that the doctor appointed to you, since your doctor is responsible for your appointment, but not an online consultant.
Guests
Alyona
Whether it is possible to reduce a frequency of reception of a preparation Cefalexin up to 2 times, but already in greater dosage, for example on 500 mg. every 12 hours? To the child 2 years - a bronchitis.
Administrators
admin
AlyonaIn this case, the effectiveness of antibiotic therapy will be halved. The interval of taking antibiotics is not just invented. It is in the 6-hour interval that the greatest antibacterial concentration of the drug lies in the blood. Increase the interval - reduce the desired concentration.As a result, bacteria remain and have to increase the duration of treatment or fight complications.
Guests
Tatyana
Good day! Tell me, please, is it possible to take Cephalexin in conjunction with Diabeton and Metformin, with purulent hydradenitis? Thank you in advance for your response.
Administrators
admin
Tatyana, It is possible, but more careful control over the level of sugars in the blood is necessary, since it is possible to potentiate the hypoglycemic action of Glyclazide (Diabeton) with an antibiotic. In general, it is neatly possible, there is still no choice in purulent hydradenitis.
Visitors
MarinaGoodele
Your question is transferred to the drug Zinnat, where it is more appropriate.
admin
Visitors
Siciliia
Hello! To the son 2 years, a heat, a throat. The doctor prescribed a suspension, but we are allergic. How correctly to apply and what dose? Thank you in advance.
Administrators
admin
Siciliia, For children from 1 year to 6 years, the dosage is 0.5 -1 grams. In 1 ml of the finished suspension contains 25 mg of the active ingredient. The rest you will count. Specifically, how much to take medicine for your child, too, the doctor must decide internally, depending on the severity of the disease (for light and moderate weight, you can do 0.5-0.75 grams of antibiotic, with a serious infection can be raised to a gram and even higher for particularly severe infections) .

Your child is allergic and the doctor must know and consider this fact when prescribing the medicine. But if you can not do without an antibiotic - you need to try and look at the state of the child's health, how he will react to taking Cephalexin's suspension. If the allergy was specifically for Cephalexin or other antibiotics of the Cephalosporin group, then it should not be used and replacement with antibiotics of another group is necessary.
Guests
olga
Cefalexin was advised by a pharmacist. At reception has felt inexplicable vivacity and there was no hypoglycemic action. I went to the doctor - prescribed a 500 glevo and immediately a strong hunger, sweating, a worse mood, heavily overeaten, sugar 7.5 after eating immediately,I return to cephalexin - it has an anorexigenic effect and treats without side effects. And what's strange - it invigorates me.
Visitors
MarLenSvo
Good day! Tell me, please, whether along with cephalexin should take antiallergic drugs and drugs that normalize the intestinal microflora. Thank you!
Administrators
admin
MarLenSvoIt is not necessary to take these medications when treated with any antibiotic. Because the allergic reaction, if it is extinguished with antiallergic drugs during the antibiotic intake, will not manifest itself anyway, and not the fact that it is not more severe, down to an anaphylactic reaction, which is life threatening.

And bacterial preparations with simultaneous administration of antibiotics are also useless, since all the useful microbes entering the body are immediately destroyed by an antibiotic, which, without parsing, kills all the harmful and beneficial in the body, sterilizing the microflora. So it's better to leave preparations of bifido-, lacto- and other bacteria for admission after the end of the course of treatment with Cephalexin.Although this is also not necessary, even if there is an easing of the stool, it passes when eating live kefir or curdled milk.
Guests
Irina
Hello can I take a suspension of Cephalexin and Nurofen suppositories at the same time?
Administrators
admin
Irina, Of course you can. Often it is this combination, say, children with bronchitis and concomitant fever (elevated temperature) and appoint. According to the instructions and from the experience of using negative side effects when taking together the drugs mentioned in the question should not be.
Guests
Olga
Hello to my daughter for 5 months. The diagnosis of obstructive bronchitis of the first degree and the temperature is already 4 days then falls, then rises. In what doses can you give cephalexin?
Administrators
admin
Olga, Acute bronchitis is treated with antibiotics. Your daughter has an obstructive and independent prescription of antibiotics without affecting the obstructive componentnothing will. Your child needs comprehensive treatment with a specialist, not online advice on the prescription of antibiotics. It is possible that the increase in temperature is caused not by bronchitis, and joined ARVI, but you will be authentically answered only by the district pediatrician who observes the child.
Guests
liana
Tell me, please, a child of 6 years was diagnosed with lymphadenitis and prescribed sumamed 250 mg. What is better than sumamed or cephalexin?
Administrators
admin
liana, A 6-year-old child is allowed to give both Sumamed in tablets of 125 mg, and a suspension of the antibiotic Cephalexin. So take the medicine that is recommended by your child's doctor. Any of the means is acceptable to use at your age.
Guests
Irina
Good afternoon. Tell me, the child is 1.6 years old, cough, temperature, the doctor prescribed cephalexin in capsules, take 5 days already, and the temperature does not fall, why? Maybe they do not fit or just a little time has passed? Thank you!
Administrators
admin
Irina, For 5 days of taking an antibiotic, changes in the course of the illness should already have occurred, at least minimal if the condition is severe. I advise you to contact the attending physician to take the necessary tests and make corrections to the treatment.
Visitors
Lenok212
Good afternoon! You can take cephalexin 500 with gv, how often? I can not change anything, only this remedy for purulent sore throat helps.
Administrators
admin
Lenok212, Everything is in the instructions to the drug: "If you need to prescribe the drug during lactation, you should stop breastfeeding." Breast milk for the time of antibiotic treatment is expressed and discarded, and the infant is fed the formula. Otherwise, do not seek other antibiotics (for example, Vilprafen Solutab can be used with breastfeeding and without interrupting feeding).
Guests
Ayshat
Hello! My son has 10 months of red throat, snot and cough.The temperature lasted 2 days, now it's normal. The doctor prescribed cefalexin 2.5 ml 3 r per day. After it, a rash on the back and a stain on the face.
Visitors
nadezcda
Good afternoon. Tell me, please, the child was 2.8 years old about. bronchitis? ARVI. A stuffy nose, a red throat, a cough. An antibiotic sumamed 125 mg was prescribed. for 3 days, and then told to change to cephalexin a suspension of 1 tsp. 3 times a day. Tell or say at a suspension one dosage or different? The doctor did not indicate the dosage at discharge of the medicine. How to be, if different, what to buy? Thank you so much.
Administrators
admin
nadezcda, Cephalexin Suspension has three dosages of 125 mg, 250 mg and 500 mg. And what to buy is better to clarify with the doctor, because I can answer only the lines from the instruction: "In children with a body weight of less than 40 kg, the average daily dose is 25-50 mg / kg (depending on the severity of the disease), with severe infection, the dosage may be increased to 100 mg / kg. " In your case, for a child weighing 2.8 kg, the dosage will be in the range of 70-140 mg of cephalexin on average and the frequency of reception 4 times a day, rather than 3 as recommended by the child's attending physician.
Guests
Olesya
Hello, we were prescribed Suprax from the initial stage of bronchitis and acute pharyngitis. The question is whether it can be replaced with cephalexin. Just six months ago with pharyngitis appointed him, and now a doroguschee prescribed medicine.
Administrators
admin
Olesya, Supraks - cephalosporin of the 3rd generation, Cephalexin - cephalosporin of the 1st generation. According to the active substance and the pharmacological group, the preparations are not identical, replacement is possible only through the attending physician, who can assess the severity of the infectious process in the patient and prescribe the necessary antibiotic.
Guests
Kika
Can I mix cephalexin with alcohol?
Administrators
admin
Kika, No. Antibiotics are forbidden to be used together with alcohol, the liver does not say thank you for it.
Visitors
missbombina
The doctor prescribed cefotaxime in injections for the treatment of bronchitis and chronic pyelonephritis. But I have a small baby and I do not have the opportunity to give injections.Cefotaxime is an antibiotic of the 3rd generation and is its analogue of the 1st generation - Cephalexin. Get rid of Klebsiella pneumoniae and Staphylococcus epidermidis. In the sensitivity analysis, it was cefotaxime that proved resistant to bacteria. Also I breastfeed and stop feeding for the period of treatment for certain reasons I can not. Can I replace Cefotaxime with cephalexin, as I understand it is antibiotics from one group, but of different generations. Plus, Cefalexin is in capsules.
Administrators
admin
missbombina, The first point - to treat with a made antibioticogram is necessary, of course, sensitive to all established pathogens antibiotics. If the bacteria are resistant to Cefotaxime - this is a bad choice to start treatment. The second point - all the antibiotics indicated in the question (Cefalexin and Cefotaxime) pass into breast milk and their use in the treatment of the mother with simultaneous breastfeeding may adversely affect the baby's microflora. It turns out the child will be treated with the same antibiotics and he needs it? So the baby is fed for the time of treatment with the mixtures, and the milk is decanted and thrown away.Or select sensitive antibiotics that can be used for feeding, for example, Jozamycin and its analogs.
Guests
Olga
Hello. The eldest son of 2.3 years has not had a coughing barking for a week, and the temperature has appeared since yesterday. The doctor prescribed to drink cefalexin, the cough became rare, but still still coughs up everything from him, and the temperature does not go away, plus more snot-transparent runaways (it's only 2 days we take an antibiotic). Tell me, for what time of admission should come the improvement and the arrival of temperature in the norm? Thank you in advance.
Administrators
admin
OlgaIf the improvement does not occur 3-4 days after the start of antibiotic intake, you can ask about the ineffectiveness of this drug in a particular patient and replace it with another medicine.
Visitors
AnnaCarpo
Good afternoon, and how many days after taking the drug you can drink alcohol? In advance it is grateful for the answer.
Administrators
admin
AnnaCarpo, Alcohol in general is harmful, it is not the product without which you can not do without. Completely removed cephalexin in a healthy person for 8 hours after the last reception. So that the next day you can assume that the traces of antibiotic in the blood will not be exactly.
Guests
a guest
Hello. The doctor prescribed the child cefalexin 125 mg to take 5 ml, but in the pharmacies found only cephalexin 250 mg, said if given on 2.5 ml, it turns out the same as cephalexin 125 mg of 5 ml. Is it so?
Administrators
admin
a guest, It turns out so it is with all other things being equal.
Visitors
olja-solnce
Hello. The dermatologist has appointed or nominated to me a cephalexin from illness ZHibera, but this virus disease how much or as far as I have understood. Is this antibiotic effective against viruses?
Administrators
admin
olja-solnce, The cause of Zhibera's disease or pink lichen is currently unknown, so they write with the same uncertainty that possible causes can be caused by both bacteria and viruses, in particular the herpes virus.I'm more inclined to the viral theory of the origin of this disease, since the process is activated after the catarrhal infections, hypothermia and other negative, but rather nonspecific factors. Therefore, when diagnosing this particular disease, I would not use the antibiotic Cefalexin. But to be treated by your doctor, so I would consult with another dermatologist to resolve all the questions and doubts, remotely setting the correct diagnosis will be difficult, and skin diseases have a similar symptomatology in the highest degree.
Guests
Marzipan
Does cephalexin in the capsules smell? It seems to me that it stinks a lot of koshatin.
Administrators
admin
MarzipanMost antibacterial drugs have a specific odor and Cephalexin is no exception. This is a normal phenomenon, but already everyone smells like this is a question of his horizons, for some he is very wide :)
Visitors
Nat04
Hello. Prompt, at a cystitis it is possible to apply cefalexin on thoracal feeding? To the child 1 year, I can not interrupt feeding.
Administrators
admin
Nat04, In strict adherence, the use of the antibiotic Cefalexin in nursing mothers is permissible. For the state of the child, it is necessary to monitor and abolish breastfeeding or replace the drug with another one on the recommendation of the doctor if you have any incomprehensible symptoms in your baby.

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