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Zinnat - instructions for use, reviews, analogs and forms of release (tablets of 125 mg and 250 mg, granules for the preparation of antibiotic suspensions) drugs for the treatment of angina, pyelonephritis, bronchitis in adults, children and pregnancy

Zinnat - instructions for use, reviews, analogs and forms of release (tablets of 125 mg and 250 mg, granules for the preparation of antibiotic suspensions) drugs for the treatment of angina, pyelonephritis, bronchitis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Zinnat. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of antibiotics Zinnat in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Zinnat in the presence of existing structural analogues. Use for the treatment of angina, pyelonephritis, bronchitis and other infections in adults, children,as well as during pregnancy and lactation.

 

Zinnat 2-generation cephalosporin antibiotic for parenteral use. It acts bactericidal, it breaks the synthesis of the bacterial cell wall. Has a wide range of action.

 

Resistant to the action of most beta-lactamases.

 

Cefuroxime (active ingredient of Zinnat antibiotic) is highly active against aerobic Gram-positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis (including strains resistant to penicillins and with the exception of rare methicillin-resistant strains), Streptococcus pyogenes (and other beta-hemolytic streptococci), Streptococcus pneumoniae, Streptococcus group B (Streptococcus agalactiae), Streptococcus mitis (viridans group), Bordetella pertusis; aerobic Gram-negative bacteria: Escherichia coli, Klebsiella spp., Proteus mirabilis, Providencia spp., Proteus rettgeri, Haemophilus influenzae (including ampicillin-resistant strains), Haemophilus parainfluenzae (including ampicillin-resistant strains), Moraxella (Branhamella) catarrhalis, Neisseria gonorrhoeae including strains that produce and do not produce penicillinase), Neisseria meningitidis, Salmonella spp .; anaerobic Gram-positive bacteria: Peptococcus spp., Peptostreptococcus spp., Clostridium spp, Propionibacterium spp .; anaerobic gram-negative bacteria: Bacteroides spp, Fusobacterium spp .; Also active against Borrelia burgdorferi.

 

By Cefuroxime resistant Clostridium difficile, Pseudomonas spp., Campylobacter spp., Acinetobacter calcoaceticus, Listeria monocytogenes, methicillin-resistant strains of Staphylococcus aureus, methicillin-resistant strains of Staphylococcus epidermidis, Legionella spp.

 

In studies, it has been shown that when combining cefuroxime with antibiotics from the aminoglycoside group, an additive effect is observed, and in some cases - synergism.

 

Composition

 

Cefuroxime (in the form of cefuroxime axetil) + auxiliary substances.

 

Pharmacokinetics

 

After ingestion, Zinnat is absorbed from the digestive tract and rapidly hydrolyzes in the intestinal mucosa and blood with the release of cefuroxime into the systemic bloodstream. The food accelerates the absorption of the cefuroxime axetil suspension. When the suspension is taken, the rate of absorption of cefuroxime axetil is lower than when taking tablets. Cefuroxime is not biotransformed in the body, excreted by the kidneys in an unchanged form by glomerular filtration and tubular secretion.

 

Indications

 

Treatment of infectious-inflammatory diseases caused by microorganisms sensitive to the preparation:

  • respiratory tract infections (including acute and chronic bronchitis, infected bronchiectasis, bacterial pneumonia, lung abscess, postoperative infections of the thorax organs);
  • infections of the ear, throat, nose (including sinusitis, tonsillitis, pharyngitis, acute otitis media);
  • infection of the genitourinary system (incl.acute and chronic pyelonephritis, cystitis, urethritis, asymptomatic bacteriuria);
  • infections of the skin and soft tissues (including furunculosis, pyoderma, impetigo);
  • gonorrhea (including acute uncomplicated gonococcal urethritis and cervicitis);
  • Lyme disease treatment at an early stage and the subsequent prevention of late manifestations in adults and children over 12 years of age.

 

Forms of release

 

Tablets coated with 125 mg and 250 mg.

 

Granules for the preparation of a suspension for oral administration (sometimes mistakenly referred to as syrup).

 

Instructions for use and dosage

 

For adults, a single dose on average is 250 mg, the frequency of admission - 2 times a day.

 

In severe infections of the lower respiratory tract appoint 500 mg twice a day; for infections of mild and moderate severity - 250 mg twice a day.

 

With infections of the urinary tract appoint 125 mg twice a day, with pyelonephritis - 250 mg 2 times a day.

 

In the treatment of uncomplicated gonorrhea appoint 1 g once.

 

With Lyme disease, adults and children over 12 years old - 500 mg twice a day for 20 days.

 

Children under the age of 12 can be given a drug in the form of a suspension. The average dose for children with most infections is 1 tablet (125 mg) 2 times a day.In severe infections or otitis media, in children aged 2 years and older, the average dose is 1 tablet (250 mg) or 2 tablets (125 mg) twice a day.

 

For infectious diseases of mild and moderate severity, a single dose is established at the rate of 10 mg / kg of body weight.

 

With the average otitis and severe infections, a single dose is set at a rate of 15 mg / kg. Multiplicity of admission - 2 times a day.

 

The maximum daily dose is 500 mg.

 

The duration of the drug on average is 7 days (5-10 days).

 

The drug is recommended after eating.

 

Side effect

  • nausea, vomiting;
  • diarrhea;
  • jaundice;
  • cases of pseudomembranous colitis are described;
  • Hemolytic anemia, eosinophilia, neutropenia, thrombocytopenia, leukopenia;
  • skin rash;
  • itching;
  • hives;
  • fever;
  • erythema multiforme;
  • Stevens-Johnson syndrome;
  • toxic epidermal necrolysis;
  • serum sickness;
  • anaphylaxis;
  • headache;
  • a positive Coombs reaction.

 

Contraindications

  • increased sensitivity to antibiotics of the cephalosporin group.

 

Application in pregnancy and lactation

 

Zinnat is used with caution in the first trimester of pregnancy and during lactation.

 

In experimental studies, embryotoxic and teratogenic effects of Zinnata have not been established.

 

Use in children

 

Possible use in children from 3 months of age.

 

special instructions

 

With special care, Zinnat is prescribed to patients with increased sensitivity to antibiotics of the penicillin series, there are reports of cases of cross-allergic reactions.

 

With prolonged use of Zinnat, an increased growth of resistant microorganisms (Candida, Enterococci, Clostridium difficile) is possible, which may require discontinuation of treatment.

 

When there is diarrhea against the background of antibiotics, incl. Zinnata, one should keep in mind the possibility of developing pseudomembranous colitis.

 

When treating Zinnat with Lyme disease, the Jarish-Gersheimer reaction is sometimes noted. This reaction is a direct consequence of the bactericidal action of Zinnat on the causative agent of the spirochaete Borrelia burgdorferi. Patients need to explain that this is a frequent and common, spontaneous passing effect of antibiotic treatment of Lyme disease.

 

When prescribing Zinnat, patients with diabetes should consider the presence of sucrose in the suspension.

 

Since in patients receiving cefuroxime axetil, a test with ferrous chloride can produce a false negative result, glucose oxidase or hexokinase methods are recommended to determine the level of glucose in the blood. Cefuroxime does not affect the results of determining the level of creatinine using alkali and picric acid.

 

Granules or the prepared suspension should not be mixed with hot liquids.

 

Drug Interactions

 

Simultaneous administration of cefuroxime and probenecid results in an increase in the AUC of cefuroxime by 50%.

 

With the simultaneous use of antacids can reduce the bioavailability of Zinnat in the form of a suspension.

 

Analogues of the drug Zinnat

 

Structural analogs for the active substance:

  • Aksetin;
  • Axosafe;
  • Antibioksim;
  • Acenoveis;
  • Zinatsef;
  • Zinoxymor;
  • Ketoceph;
  • Ksorim;
  • Proxim;
  • Super;
  • Cetil Lupine;
  • Cefroxime J;
  • Cefurabol;
  • Cefuroxime;
  • Cefuroxime sodium;
  • Cefuroxime sodium is sterile;
  • Cefuroxime axetil;
  • Cephus.

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Reviews (14):
Guests
Elena
I got somehow in the off-season to dress not for the weather. It was very cold. And my weak on hypothermia kidneys did not take long to wait, soon laying me pyelonephritis with a high temperature in bed. Complicated all this with acute bronchitis and cystitis. For the first time I was confronted with the fact that the temperature can not be knocked down, but it fluctuates in the range 39.5-39.9. Called to the house therapist appointed a drug Zinnat. It is convenient that you need to drink it 3-4 times a day, but only 2. And he miraculously covered all my diseases at the same time with his action. The drug was effective from the first reception. The temperature stopped rising above 39.5. Further - better. The course of my treatment was a maximum of 10 days. Of the side effects, only a headache and a little nausea were observed. But these are such trifles, in comparison with the relatively rapid normalization of temperature, that I did not even pay attention to them.

A neighbor has a daughter, 4.5 years. They suspected pneumonia. And they also successfully treated her with Zinnat, only they drank the drug in the form of a suspension. The taste, however, the girl complained, but the fear to rumble to the hospital was more, so they still drank.The main thing that helps, and the delicacy / insipiability can be tolerated.
Guests
Olesya
To us this antibiotic did not go at all. My daughter is 2.6 years old, has otitis media. With the first spoon began to vomit, I tried to give on an empty stomach before eating, just as everything vomited. She did not give any more.
Guests
Victoria
My son was sick heavily. It started with Orvi, ended with bronchitis with a very high continuous temperature. Assigned zinnat in the form of a syrup from granules. Tear is terrible. They switched to zinnat tablets and normally drank the course, recovered very quickly.
Guests
zilya
Today I called a doctor at home, prescribed zinnat, essential. (I have a weak throat, a little blow, I immediately get sore throat, I do not know how to heal). I will write about the results later ...
Guests
Alexey
A good antibiotic for the treatment of serious diseases. Ill son - 5 years of age. The pediatrician missed pneumonia, eventually was taken to the hospital, where in the beginning they injected some Cef intramuscularly, and then they were already cured by Zinnat.As a result, they helped to save his son, for which thanks to all doctors, except our pediatrician, here he is driven by a broom from medicine.
Guests
Larissa
I have a child of 5 years. They appointed Zinnat. I can not normally give a suspension, immediately vomiting. I can not force it. I did not like.
Administrators
admin
Site visitor question MarinaGoodele moved to the required section:
Hello. I want to ask. To a daughter of 7 years have written out Zinnat 250 suspension on 5 ml for 12 hours. Can I replace the suspension with Zinnat 250 tablets and give 1 tablet 2 times a day. Thank you in advance for your response.

MarinaGoodeleIn 5 ml of suspension of Zinnat antibiotic contains 125 mg of active cefuroxime, it means that in order to observe the dosage prescribed by the doctor for the child, it is necessary to give half the Zinnat 250 tablet, and since this preparation is available in coated tablets, it can not be divided. But there are tablets of Zinnat 125 mg, which will suit your dosage. You can take 1 tablet 125 mg 2 times a day, this will correspond to a suspension of Zinnat 250 to 5 ml 2 times a day.
Guests
Zhenya
Good afternoon.Tell the sachet from the divorced sachet to give 5 ml on the glass floor? The rest is stored in the refrigerator?
Administrators
admin
Zhenya, Dosage of antibiotic Zinnat is necessary depending on the age and weight of the child. And for the preparation of the suspension from the granules, it is necessary to fill the measuring cup attached to the medicine with a volume of 37 ml with warm boiled water and pour this water into the powder bottle and shake to obtain a white suspension very similar to syrup. And this mass has already been dosed as the doctor advised your child. Ready suspension stored in the refrigerator.
Guests
Irina
Hello. Really a very good drug. She gave her daughter when she was 3 years old. The result was noticeable literally the next day.
Guests
Alice
Zinnat is an antibiotic of 2nd generation. Better already take antibiotics 3 generations. They are more expensive, but they are worth it (zinnat about 300 rubles). The difference is huge. Zinnat just need to drink and drink (2 times a day) and 3-5 days to act, also give a bunch of other medicines (antipyretic, from the throat) at this time - because the pace rises.In general, I will not take any more. I regretted taking the advice of a pharmacist. I wanted to save money.
Guests
Victoria
Hello. Explain, please, suspension 125, I diluted 37 ml of water as per the instructions. The child should be given 125 at a time, twice a day. I understood everything, but I can not understand what to breed, and what to add for a one-time reception of 125 from a common bottle.
Administrators
admin
Victoria, I may not quite understand the question (then register, as required by the rules of the Directory and specify it). In the kit to the suspension of the antibiotic Zinnat is a measuring cup to read 37 ml of liquid to dilute the drug powder to a suspension and a measuring spoon. In a vial of antibiotic, pour 37 ml of warm boiled water (measure with a measuring cup), shake the bottle well for several minutes until the powder is completely dissolved. Then we measure the prescribed quantity with a measuring spoon and give it to the child. We do not breed anything further. The spoon is 5 ml, this volume contains 125 mg of the active substance cefuroxime, but how many spoons, that is, the dosage, determines the doctor, depending on the severity of the infectious disease and age-weight of the child.
Guests
Yana
Zinnat did not go to us 0%.

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