Drotaverin - instructions for use, reviews, analogs and forms of release (tablets 40 mg hydrochloride and 80 mg forte, injections in ampoules for injection) drugs for the treatment of muscle and vascular spasm in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Drotaverine. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Drotaverina hydrochloride in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Drotaverin in the presence of existing structural analogues.Use to treat spasm of muscles and vessels leading to headache, kidney colic in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Drotaverine - Myotropic antispasmodic. The chemical structure and pharmacological properties are close to papaverine, but it has a stronger and longer action. Reduces the flow of ionized active calcium into smooth muscle cells by inhibiting phosphodiesterase and intracellular accumulation of CAMP. Reduces the tone of smooth muscles of internal organs, reduces their motor activity, dilates blood vessels. Does not affect the autonomic nervous system, does not penetrate the central nervous system. Due to direct influence on smooth muscles, it can be used as an antispasmodic in cases when drugs from the group of holinoblockers are contraindicated (closed-angle glaucoma, prostate adenoma).

Composition

Drotaverina hydrochloride + excipients.

Pharmacokinetics

When taken orally, absorption is high, the half-absorption period is 12 min. Bioavailability is 100%.Evenly distributed on the tissues, penetrates into the smooth muscle cells. It is mainly excreted by the kidneys, to a lesser extent - with bile. Does not penetrate the blood-brain barrier.

Indications

• spasm of smooth muscles of internal organs: renal colic, biliary colic, dyskinesia of bile ducts and gallbladder according to hyperkinetic type, intestinal colic;
• pielit, cholecystitis;
• spastic constipation, spastic colitis, proctitis, tenesmus;
• pilorospasm;
• peptic ulcer of the stomach and duodenum (in the phase of exacerbation, as part of complex therapy);
• pain syndrome with spasms of peripheral arterial vessels (endarteritis), cerebral vessels, coronary arteries;
• Algodismenorea, threatening miscarriage, threatening premature birth;
• spasm of the uterus pharynx during labor, prolonged opening of the throat, postnatal contractions;
• for carrying out some instrumental studies, cholecystography.

Forms of release

Tablets of 40 mg.

Tablets 80 mg Drotaverin forte.

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

Instructions for use and dosage

Adults, inside of 40-80 mg (1-2 tablets) 2-3 times a day.

Children, inside at the age of 3-6 years - 40-120 mg in 2-3 doses, the maximum daily dose - 120 mg; 6-18 years - 80-200 mg in 2-5 receptions, the maximum daily dose - 240 mg.

Side effect

• dizziness;
• headache;
• insomnia;
• palpitation;
• tachycardia;
• sensation of heat;
• increased sweating;
• nausea;
• constipation;
• lowering blood pressure;
• allergic skin reactions;
• angioedema;
• hives;
• rash;
• itching.

Contraindications

• hypersensitivity to the components of the drug;
• expressed hepatic, renal insufficiency;
• lactation period;
• children under 3 years;
• intolerance to galactose;
• deficiency of lactase;
• glucose-galactose malabsorption.

Application in pregnancy and lactation

Controlled studies in pregnant women have not been conducted, but the potential benefit can justify the use of drotaverine for the mother, despite the possible risk to the fetus. Contraindicated during breastfeeding.

Drotaverine does not have teratogenic and embryotoxic effects.

special instructions

When treating gastric ulcer and duodenal ulcer are used in combination with other antiulcer drugs.

During the treatment period it is necessary to refrain from driving motor vehicles and practicing other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

With the simultaneous use of drotaverine can weaken the antiparkinsonian effect of levodopa. Strengthens the effect of papaverine, bendazole and other antispasmodics (including m-holinoblokatorov), lowering arterial pressure caused by tricyclic antidepressants, quinidine and procainamide.

Phenobarbital increases the severity of spasmolytic action of drotaverine. Reduces the spasmogenic activity of morphine.

Analogues of the drug Drotaverine

Structural analogs for the active substance:

• Vero-Drotaverine;
• Droverin;
• Drotaverin MS;
• Drotaverin forte;
• Drotaverin UBF;
• Drotaverin FPO;
• Drotaverine Ellara;
• Drotaverina hydrochloride;
• But-shpa;
• But-shpa fort;
• Nosh-Bra;
• Ple-Spa;
• Spazmol;
• Spasmonet;
• Spasmonet forte;
• Cosporeine;
• Spacock.

Similar medicines:

Other medicines: