Nemozol - instructions for use, analogs, reviews and release forms (tablets 200 mg and 400 mg, suspension for ingestion) drugs for the treatment of worms (ascaridosis, giardiasis) in adults, children and pregnancy
In this article, you can read the instructions for using the drug Nemosol. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Nemozol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Nemosol in the presence of existing structural analogues. Use to treat worms (ascariasis, giardiasis) in adults, children, as well as during pregnancy and lactation.
Nemosol - anthelmintic preparation.The main mechanism of action is associated with an inhibitory effect on the polymerization of beta-tubulin, which leads to the destruction of cytoplasmic microtubules of intestinal tract cells of helminths; changes the course of biochemical processes (suppresses the utilization of glucose), blocks the movement of secretory granules and other organelles in the muscle cells of roundworms, causing their death. The most active against the larval forms of cestodes is Echinococcus granulosus and Taenia solium, the nematodes are Strongyloides stercolatis.
Composition
Albendazole + auxiliary substances.
Pharmacokinetics
After oral administration, it is poorly absorbed from the digestive tract, unchanged in the blood plasma. Bioavailability when ingested is low, about 30%. Admission simultaneously with fatty foods increases absorption by 5 times. Albendazole is rapidly biotransformed in the liver into the primary metabolite, albendazole sulfoxide, which also has anthelmintic activity. Albendazole sulfoxide is almost completely distributed throughout the body; is found in urine, bile, liver, in the wall of the cyst and cystic fluid, cerebrospinal fluid. It is excreted in the form of various metabolites with urine.
Indications
- Nematodosis (ascariasis, enterobiasis, ankylostomiasis, non-catarosis, trichocephalosis);
- mixed worm infestations;
- strongyloidiasis;
- neurocysticercosis caused by the larval form of Taenia solium;
- echinococcosis of the liver, lungs, peritoneum, caused by the larval form of Echinococcus granulosus;
- giardiasis;
- toxocarosis;
- as an auxiliary in the surgical treatment of echinococcus cysts.
Forms of release
Tablets coated with 200 mg and 400 mg.
Tablets chewing 400 mg.
Suspension for oral administration.
Instructions for use and reception scheme
The average therapeutic dose for the treatment of nematodes for adults and children over 2 years is 400 mg or 20 ml of the suspension orally once.
The drug is taken during meals. It is recommended that all members of the family be treated at the same time.
With neurocysticercosis and echinococcosis, patients with a body weight of 60 kg or more receive 400 mg twice a day; with a body weight of less than 60 kg, the dose is set at a rate of 15 mg / kg per day in 2 divided doses. The maximum daily dose is 800 mg (400 mg twice a day). The course of treatment for neurocysticercosis - 8-30 days; with echinococcosis - 3 cycles of 28 days with a 14-day interval between cycles.
With giardiasis for children, the drug is prescribed at a rate of 10-15 mg / kg once a day for 5-7 days.
With toxocarosis, adults and children over 14 years of age with a body weight of more than 60 kg are prescribed 400 mg twice a day; with a body weight of less than 60 kg - 200 mg twice a day; Children under 14 years of age are given a dose of 10 mg / kg 2 times a day. Duration of therapy is 7-14 days.
Side effect
- impaired liver function with changes in functional liver tests (mild or moderate increase in transaminase activity);
- abdominal pain;
- nausea, vomiting;
- leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia;
- headache;
- dizziness;
- meningeal symptoms;
- reversible alopecia;
- skin rash;
- itching;
- temperature increase;
- increased blood pressure;
- acute renal insufficiency;
- allergic reactions.
Contraindications
- retinal damage;
- pregnancy;
- hypersensitivity to the components of the drug and other benzimidazole derivatives.
Application in pregnancy and lactation
The drug is contraindicated for use in pregnancy. If it is necessary to prescribe the drug during lactation, the question of stopping breastfeeding should be solved.
Before prescribing the drug should be tested for the lack of pregnancy in women of childbearing age. During the period of therapy, reliable methods of contraception should be used.
Use in children
Possible use according to the indications and in doses that take into account the age of the patients.
special instructions
With neurocysticercosis, appropriate treatment with glucocorticosteroids (GCS) and anticonvulsant drugs should be performed. GCS for oral or intravenous administration is used to prevent hypertensive seizures during the first week of anti-cystic therapy.
Against the background of the use of the drug, it is recommended to control the cellular composition of the blood. When leukopenia occurs, the therapy is suspended.
Blood tests should be performed at the beginning of each 28-day cycle every 2 weeks during the treatment with Nemosol. Continue treatment with Nemosol is possible if a decrease in the total content of leukocytes and neutrophilic leukocytes is moderate and does not progress.
Drug Interactions
When combined with albendazole, Dexamethasone and cimetidine increase the concentration of albendazole sulfoxide in the blood.
Analogues of the drug Nemozol
Structural analogs for the active substance:
- Gelmodol-VM;
- Sanoxal.
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