Spazmalgon - instructions for use, reviews, analogs and forms of release (tablets, injections in injectable ampoules) for the treatment of pain, including with menstruation in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Spazmalgon. Comments from visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Spazmalgon in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Spasmalgon in the presence of existing structural analogues. Use for the treatment of pain, including with menstruation in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Spazmalgon - spazmanoanalgikik combined composition, the combination of components which leads to a mutual enhancement of their pharmacological action.

Metamizole sodium is an analgesic-antipyretic, a derivative of pyrazolone. Has a pronounced analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with the inhibition of the synthesis of prostaglandins.

Pitofenone hydrochloride - myotropic antispasmodic, has a direct effect on the smooth muscles of the internal organs and causes its relaxation (papaverin-like action).

Fenpiverinia bromide, being an m-holinoblokatorom, has an additional relaxing effect on smooth muscles.

Composition

Metamizol sodium + Pitophenone (in the form of hydrochloride) + Fenpiperinium bromide + auxiliary substances.

Pharmacokinetics

After intramuscular injection, the active substances of the preparation are rapidly and largely absorbed from the injection site. Binding to plasma proteins is 50-60%. When taken in therapeutic doses, it is excreted in breast milk. It is excreted mainly by the kidneys.

Indications

Weak or moderately expressed pain syndrome with spasms of smooth muscles of internal organs:

• renal colic, spasm of ureter and bladder;
• biliary colic;
• intestinal colic;
• biliary dyskinesia;
• postcholecystectomy syndrome;
• chronic colitis;
• algodismenorea (painful menstruation);
• diseases of the pelvic organs.

For short-term treatment: arthralgia, myalgia, neuralgia, ischialgia.

As an auxiliary medicine: pain syndrome after surgical interventions and diagnostic procedures.

Forms of release

Pills.

Solution for intramuscular injection (injections in ampoules for injection 2 ml and 5 ml).

Instructions for use and dosage

Pills

Inside: adults and adolescents over 15 years: 1-2 tablets 2-3 times a day, without chewing, squeezed a small amount of liquid.

Children 12-14 years: single dose - 1 tablet, maximum daily dose - 6 tablets (1.5 tablets 4 times a day), 8-11 years - 0.5 tablets, maximum daily dose - 4 tablets (1 tablet 4 times a day) , 5-7 years - 0.5 tablets, the maximum daily dose - 2 tablets (0.5 tablets 4 times a day).

Ampoules

For adults, the drug is administered intramuscularly for 2-5 ml of a solution for 2-3 days. The duration of the course of treatment is determined depending on the clinical symptomatology and etiopathogenesis of the disease, but should not exceed 5 days.

The maximum daily dose should not exceed 10 ml (correspondingly 5 g of metamizole sodium).

In the absence of a therapeutic effect, the drug should be discontinued, with a good or satisfactory effect, should be switched to oral or rectal administration.

Before the injection of the injection solution, it should be warmed in the hands.

Side effect

• impaired renal function;
• oliguria;
• anuria;
• proteinuria;
• interstitial nephritis;
• staining the urine in red;
• agranulocytosis, leukopenia, thrombocytopenia;
• dry mouth;
• decreased sweating;
• tachycardia;
• difficulty urinating;
• urticaria (including conjunctiva and mucous membranes of the nasopharynx);
• angioedema;
• malignant exudative erythema (Stevens-Johnson syndrome);
• toxic epidermal necrolysis (Lyell's syndrome);
• bronchospasm;
• anaphylactic shock;
• a decrease in blood pressure;
• infiltrates at the injection site.

Contraindications

• oppression of bone marrow hematopoiesis;
• severe hepatic impairment;
• severe renal failure;
• deficiency of glucose-6-phosphate dehydrogenase;
• tachyarrhythmia;
• severe angina;
• heart failure in the stage of decompensation;
• angle-closure glaucoma;
• hyperplasia of the prostate with clinical manifestations;
• intestinal obstruction;
• megacolon;
• collapse;
• pregnancy (especially 1 and 3 trimester);
• lactation period (breastfeeding);
• children's age till 15 years;
• hypersensitivity to the drug components and other pyrazolone derivatives.

Application in pregnancy and lactation

Contraindicated use of the drug during pregnancy (especially in 1 and 3 trimesters).

If it is necessary to use Spazmalgon during lactation, breastfeeding should be stopped for the duration of the drug intake.

special instructions

If suspected of agranulocytosis or in the presence of thrombocytopenia, the drug should be discontinued.

The use of the drug for the relief of acute pain in the abdomen is unacceptable until the cause of the disease is clarified.

Special care should be taken when administering more than 2 ml of solution (there is a risk of a sharp decrease in blood pressure).

Impact on the ability to drive vehicles and manage mechanisms

Care should be taken during the treatment of drivers of vehicles and persons engaged in potentially hazardous activities requiring quick physical and mental reactions.

Drug Interactions

Contraindicated simultaneous use with radiocontrast drugs, colloid blood substitutes and penicillin.

With the simultaneous use of the drug with cyclosporine, the concentration of the latter in the blood decreases.

With the simultaneous use of metamizole sodium, displacing from the bond with protein oral hypoglycemic agents, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity.

With simultaneous use of phenylbutazone, barbiturates and other inducers of microsomal liver enzymes reduce the effectiveness of metamizole sodium.

When used simultaneously with other non-narcotic analgesics, tricyclic antidepressants, oral hormonal contraceptives and allopurinol, toxicity may be increased.

With the simultaneous use of sedatives and anxiolytics (tranquilizers) enhance the analgesic effect of Spasmalgon.

With simultaneous use of thiamazole and cytotoxic drugs increase the risk of developing leukopenia.

With the simultaneous use of the action of the drug strengthen codeine, histamine H2 receptor blockers and Propranolol (slow inactivation).

With simultaneous use of drugs with myelotoxic effect increase the hematotoxic effect of Spasmalgon.

When co-administered with histamine H1 receptor blockers, butyrophenones, phenothiazines, tricyclic antidepressants, amantadine and quinidine, m-cholinoblocking action is possible.

The use together with chlorpromazine or other phenothiazine derivatives can lead to the development of severe hyperthermia.

With simultaneous application, Spasmalgon enhances the effects of ethanol (alcohol).

Pharmaceutical interaction

Because of the high likelihood of developing pharmaceutical incompatibility, you should not mix it with other drugs in the same syringe.

Analogues of the drug Spazmalgon

Structural analogs for the active substance:

• Baralgetas;
• I took it;
• Bralangin;
• Maxigan;
• Plenalgin;
• Revalgine;
• Renalgan;
• Spasgan;
• Spazmaline;
• Spazmoblok.

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