Tsifran - instructions for use, reviews, analogs and forms of release (tablets 250 mg and 500 mg ST and OD, eye drops, injections in ampoules) for the treatment of angina and conjunctivitis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Tsifran. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Cyphrane in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cyphrane in the presence of existing structural analogs. Use for the treatment of angina and conjunctivitis in adults, children, as well as during pregnancy and lactation.

Cyphrane - a broad spectrum antimicrobial agent of the fluoroquinolones group. Has a bactericidal effect. Suppresses DNA-gyrase and inhibits the synthesis of bacterial DNA.

Highly active against most Gram-negative bacteria: Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Shigella spp., Salmonella spp., Neisseria meningitidis, Neisseria gonorrhoeae.

It is active against Staphylococcus spp. (including strains producing and not producing penicillinase, methicillin-resistant strains), some strains of Enterococcus spp., Campylobacter spp., Legionella spp., Mycoplasma spp., Chlamydia spp., Mycobacterium spp.

Ciprofloxacin (the active substance of the preparation Cyphran) is active against bacteria that produce beta-lactamases.

Ciprofloxacin is resistant to Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. The action against Treponema pallidum has not been adequately studied.

Tinidazole is an antiprotozoal and antimicrobial agent, an imidazole derivative, effective against anaerobic microorganisms, such as Clostridium difficile, Clostridium perfringens, Bacteroides fragilis, Peptococcus and Peptostreptococcus anaerobius.

Pharmacokinetics

Quickly absorbed from the digestive tract. The intake of food slightly affects the absorption of Cyphrane. The binding with plasma proteins is 20-40%. It is distributed in tissues and body fluids. Penetrates into the cerebrospinal fluid: the concentration of Ciprofloxacin in non-inflamed meninges reaches 10%, with inflamed - up to 37%. High concentrations are achieved in bile. Excreted in urine and bile.

Indications

• Infectious-inflammatory diseases caused by microorganisms susceptible to ciprofloxacin, incl. diseases of the respiratory tract, abdominal cavity and pelvic organs, bones, joints, skin; septicemia; severe infections of the ENT organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity;
• for topical application: acute and subacute conjunctivitis, blepharoconjunctivitis, blepharitis, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meibomites. Infectious lesions of the eyes after injuries or foreign bodies. Preoperative prophylaxis in ophthalmic surgery.

Forms of release

Tablets coated with 250 mg and 500 mg (OD - prolonged action and CT - contains tinidazole).

Eye drops.

Solution for infusions (injections in ampoules for injections).

Instructions for use and dosing regimen

Individual. Inside - 250-750 mg 2 times a day. The duration of treatment is from 7-10 days to 4 weeks.

For intravenous administration, a single dose of 200-400 mg, multiplicity of administration - 2 times a day; duration of treatment - 1-2 weeks, if necessary and more.It may be administered intravenously, but more preferably a drip infusion (dropper) for 30 minutes.

When topical application is instilled in 1-2 drops in the lower conjunctival sac of the affected eye every 1-4 hours. After improvement, the intervals between instillations can be increased.

The maximum daily intake for adults when ingested is 1.5 g.

Side effect

• nausea, vomiting;
• diarrhea;
• stomach ache;
• pseudomembranous colitis;
• headache;
• dizziness;
• feeling tired;
• sleep disorders;
• nightmarish dreams;
• hallucinations;
• fainting;
• visual impairment;
• glomerulonephritis;
• dysuria;
• polyuria;
• albuminuria;
• hematuria;
• eosinophilia, leukopenia, neutropenia, change in the number of platelets;
• tachycardia;
• heart rhythm disturbances;
• arterial hypotension;
• itching;
• hives;
• angioedema;
• Stevens-Johnson syndrome;
• candidiasis;
• vasculitis;
• phlebitis (with iv introduction);
• slight soreness and congestion hyperemia (eye drops).

Contraindications

• pregnancy;
• lactation (breastfeeding);
• children and adolescence up to 15 years;
• increased sensitivity to ciprofloxacin and other drugs of the quinolone series.

Application in pregnancy and lactation

Tsifran penetrates through the placental barrier, excreted in breast milk. Application in pregnancy or breast-feeding is undesirable.

special instructions

Patients with impaired renal function require a correction of the dosing regimen. They are used with caution in elderly patients, with atherosclerosis of cerebral vessels, cerebral circulation disorders, epilepsy, convulsive syndrome of unclear etiology.

During treatment, patients should receive a sufficient amount of fluid.

In case of persistent diarrhea, Cyphran should be discarded.

With simultaneous intravenous administration of ciprofloxacin and barbiturates, it is necessary to monitor heart rate, blood pressure, and ECG. During the treatment, it is necessary to control the concentration in the blood of urea, creatinine, hepatic transaminases.

During the treatment period, a decrease in the reactivity is possible (especially when used simultaneously with alcohol).

Do not put Cyfran subconjunctivalally or directly into the anterior chamber of the eye.

Drug Interactions

With the simultaneous use of ciprofloxacin with didanosine, ciprofloxacin absorption decreases due to the formation of ciprofloxacin complexones with aluminum and magnesium buffers in didanosine.

With simultaneous use with warfarin, the risk of bleeding increases.

With the simultaneous use of Cyfran and theophylline, an increase in the concentration of theophylline in the blood plasma, an increase in T1 / 2 theophylline, which leads to an increased risk of toxic action associated with theophylline.

Simultaneous reception of antacids, as well as preparations containing ions of aluminum, zinc, iron or magnesium, can cause a decrease in absorption of ciprofloxacin, so the interval between the appointment of these drugs should be at least 4 hours.

Analogues of the drug Tsifran

Structural analogs for the active substance:

• Altsipro;
• Afenoxin;
• Basijen;
• Betaciprol;
• Vero-Ciprofloxacin;
• Zindolin 250;
• Isfipro;
• Quintor;
• Quipro;
• Liprokhin;
• Microfleks;
• Oftotsipro;
• PROCIPRO;
• Recipro;
• Siflox;
• Ceprova;
• Ciloxane;
• Cipraz;
• Ciprinol;
• Ciprobay;
• Ciprobide;
• Ciprobrin;
• Citrodox;
• Ciprolake;
• Tsiprolet;
• Ciprolone;
• Cipromed;
• Cipropane;
• Ciprosan;
• Ciprosine;
• Ciprosol;
• Ciprofloxabol;
• Ciprofloxacin;
• Cytar;
• Cifloxinal;
• The figure of OD;
• Tsifran ST;
• Ecocylol.

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