Panadol - instructions for use, reviews, analogs and formulations (500 mg tablets, Caffeine Extra, Baby Baby suspension or syrup, rectal suppositories) medications for pain and temperature in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Panadol. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Panadol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Panadol in the presence of existing structural analogs.Use to treat various pain and temperature in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Panadol - An analgesic-antipyretic. Has analgesic and antipyretic effect. Panadol Extra contains Paracetamol or a combination of two active ingredients: paracetamol and caffeine.

Paracetamol blocks COX in the central nervous system, affecting the centers of pain and thermoregulation (in cellular tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effect. The absence of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative influence on the water-salt metabolism (sodium and water retention) and gastrointestinal mucosa.

Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance.

Composition

Paracetamol + auxiliary substances.

Paracetamol + Caffeine + excipients (Panadol Extra).

Candles and syrup for children contain only paracetamol.

Pharmacokinetics

Absorption is high.Panadol quickly and almost completely absorbed from the digestive tract. The distribution of paracetamol in body fluids is relatively uniform. Metabolized mainly in the liver with the formation of several metabolites. In newborns of the first two days of life and in children 3-10 years, the main metabolite of paracetamol is paracetamol sulfate, in children 12 years and older - conjugated glucuronide. When receiving therapeutic doses, 90-100% of the dose taken is excreted in the urine within one day. The main amount of the drug is released after conjugation in the liver. In unchanged form, not more than 3% of the received dose of paracetamol is released.

Indications

• headache;
• migraine;
• toothache;
• back pain;
• neuralgia;
• muscular and rheumatic pain;
• painful menstruation;
• symptomatic treatment of colds and flu (to reduce elevated body temperature);
• to reduce elevated body temperature against colds, influenza and childhood infectious diseases (including chicken pox, parotitis, measles, rubella, scarlet fever);
• at a toothache (including at teething), a headache, an earache at an otitis and at a pain in a throat.

Forms of release

Tablets, film-coated 500 mg.

Panadol Extra tablets.

Suspension for oral administration Children's Panadol Baby (sometimes mistakenly called syrup).

Candles rectal 125 mg and 250 mg (for children).

Instructions for use and dosage

Pills

Adults (including the elderly) the drug prescribed 500 mg-1 g (1-2 tablets) up to 4 times a day, if necessary. The interval between doses is not less than 4 hours, a single dose (2 tablets) can be taken no more often than 4 times (8 tablets) for 24 hours.

Children aged 6-9 years are prescribed 1/2 tablet 3-4 times a day, if necessary. The interval between doses is at least 4 hours. The maximum single dose for children 6-9 years is 1/2 tablet (250 mg), the maximum daily intake is 2 tablets (1 g).

Children aged 9-12 years are prescribed 1 tablet up to 4 times a day, if necessary. The interval between doses is not less than 4 hours, a single dose (1 tablet) can be taken no more often than 4 times (4 tablets) for 24 hours.

The drug is not recommended for more than 5 days as an anesthetic and for more than 3 days of an antipyretic agent without prescribing and monitoring the doctor. An increase in the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Extra

Adults (including the elderly) and children over 12 years of age are prescribed 1-2 tablets 3-4 times a day, if necessary. The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets

The drug is not recommended for more than five days as an anesthetic and for more than three days as an antipyretic without prescription and supervision by a physician.

An increase in the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Suspension or syrup

The drug is taken orally. Before use, the contents of the vial should be shaken well. Measuring syringe, embedded inside the package, allows you to correctly and rationally dose the drug.

The dose of the drug depends on the age and body weight of the child.

Children older than 3 months of the drug prescribed 15 mg / kg body weight 3-4 times a day, the maximum daily dose is not more than 60 mg / kg body weight. If necessary, you can take the drug every 4-6 hours in a single dose (15 mg / kg), but no more than 4 times for 24 hours.

Do not exceed the recommended dose.

Duration of admission without consulting a doctor: to reduce the temperature - no more than 3 days, to reduce pain - no more than 5 days.

In the future, as well as in the absence of therapeutic effect, it is necessary to consult a doctor.

Rectal Candles

Inside or rectally in adults and adolescents with a body weight of more than 60 kg used in a single dose of 500 mg, the frequency of intake - up to 4 times a day. The maximum duration of treatment is 5-7 days.

Maximal doses: single dose - 1 g, daily - 4 g.

Single doses for ingestion for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single doses for rectal application in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.

Multiplicity of application - 4 times a day with an interval of at least 4 hours. The maximum duration of treatment is 3 days.

The maximum dose: 4 single doses per day.

Side effect

• rashes on the skin;
• itching;
• angioedema;
• leukopenia, thrombocytopenia, methemoglobinemia, agranulocytosis, hemolytic anemia;
• Dyspeptic disorders (including nausea, epigastric pain);
• sleep disturbance;
• tachycardia.

Contraindications

• severe liver dysfunction;
• severe renal dysfunction;
• arterial hypertension;
• glaucoma;
• sleep disorders;
• epilepsy;
• the period of the newborn;
• children under 12 years (for Panadol Extra);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Caution should be used during pregnancy and lactation.

special instructions

In cases of prolonged use in high doses, monitoring of the blood picture is necessary.

During the intake of the drug, excessive drinking of tea and coffee is not recommended, as this can lead to excitation, sleep disturbance, tachycardia, cardiac arrhythmia.

To avoid toxic damage to the liver, paracetamol should not be combined with the intake of alcoholic beverages, and should also be taken to persons prone to chronic alcohol consumption.

Patients suffering from atonic bronchial asthma, pollinosis, there is an increased risk of allergic reactions.

Can change the results of tests of doping control athletes.

Drug Interactions

When taken for a long time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.

The drug enhances the effect of MAO inhibitors.

Barbiturates, phenytoin, ethanol (alcohol), rifampicin, phenylbutazone, tricyclic antidepressants and other stimulators of microsomal oxidation increase the production of hydroxylatedactive metabolites, causing the possibility of developing severe intoxication with small overdoses.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic effects.

Under the influence of paracetamol, the time of chloramphenicol elimination is increased by 5 times.

Caffeine accelerates the absorption of ergotamine.

Simultaneous reception of paracetamol and alcoholic beverages increases the risk of hepatotoxic effects and acute pancreatitis.

Metoclopramide and Domperidone are increased, and colestramine reduces the rate of absorption of paracetamol.

The drug may reduce the effectiveness of uricosuric drugs.

Analogues of the drug Panadol

Structural analogs for the active substance:

• Akamol Teva;
• Aldolor;
• Apap;
• Acetaminophen;
• Daleron;
• Children's Panadol;
• Children's Tylenol;
• Ithymol;
• Kalpol;
• Xoomapar;
• Lupocet;
• Mexalen;
• Pamol;
• Panadol junior;
• Panadol tablets are soluble;
• Paracetamol;
• Paracetamol (Acetofen);
• Paracetamol for children;
• Paracetamol syrup 2.4%;
• Perfalgan;
• Prohodol;
• Child passed through;
• Sanidol;
• Strymol;
• Tylenol;
• Tylenol for infants;
• Febricet;
• Cefekon D;
• Efferalgan.

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