Tetracycline - instructions for use, reviews, analogs and formulations (100 mg tablets, ointment for external use 3% and ophthalmic 1%) medicinal product for the treatment of bronchitis, blepharitis, acne in adults, children and pregnancy

In this article, you can read the instructions for using the drug Tetracycline. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Tetracycline in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tetracycline in the presence of existing structural analogues.Use for the treatment of bronchitis, pneumonia, acne (acne), blepharitis and conjunctivitis in adults, children, as well as during pregnancy and lactation.

Tetracycline - broad spectrum antibiotic. Has a bacteriostatic effect due to suppression of protein synthesis of pathogens.

It is active against aerobic gram-positive and gram-negative bacteria, anaerobic bacteria.

It is also active against Rickettsia spp., Chlamydia spp., Mycoplasma spp., Spirochaetaceae.

Pseudomonas aeruginosa, Proteus spp., Serratia spp., Most strains of Bacteroides fragilis, most fungi, small viruses are resistant to tetracycline.

Pharmacokinetics

After ingestion, 60-80% of the dose is absorbed from the digestive tract. Quickly distributed in most tissues and body fluids. Penetrates through the placental barrier, excreted in breast milk. It is excreted in urine and feces unchanged.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to tetracycline:

• pneumonia;
• bronchitis;
• empyema of the pleura;
• angina;
• cholecystitis;
• pyelonephritis;
• intestinal infections;
• endocarditis;
• endometritis;
• prostatitis;
• syphilis;
• gonorrhea;
• brucellosis;
• rickettsiosis;
• purulent infections of soft tissues;
• osteomyelitis;
• trachoma;
• conjunctivitis;
• blepharitis;
• acne (pimples).

Forms of release

Tablets coated with 100 mg.

Ointment eye 1%.

Ointment for external use 3%.

Instructions for use and dosage

Pills

Inside adults - 250-500 mg every 6 hours. Children older than 8 years - 25-50 mg / kg every 6 hours.

The maximum daily intake for adults with oral intake is 4 g.

Ointment

External apply several times a day, if necessary, impose a weak bandage.

Locally - 3-5 times a day.

Side effect

• nausea, vomiting;
• anorexia;
• stomach ache;
• diarrhea;
• constipation;
• dry mouth;
• glossitis;
• changing the color of the language;
• esophagitis;
• dizziness;
• headache;
• neutropenia, thrombocytopenia, hemolytic anemia;
• skin rash;
• itching;
• eosinophilia;
• angioedema;
• photosensitization;
• candidiasis stomatitis;
• candidiasis vulvovaginitis;
• intestinal dysbiosis;
• vitamin B vitamins.

Contraindications

• liver failure;
• leukopenia;
• mycoses;
• children's age till 8 years;
• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to tetracycline.

Application in pregnancy and lactation

Tetracycline is contraindicated in pregnancy and lactation.

Penetrates through the placental barrier.May cause long-term discoloration of the teeth, hypoplasia of the enamel, suppression of the growth of the bones of the fetal skeleton. In addition, tetracycline may be the cause of the development of fatty liver infiltration.

special instructions

With prolonged use, it is necessary to periodically monitor the functions of the kidneys, liver, and hematopoiesis.

The use of tetracycline in children during the development of teeth can lead to an irreversible change in their color.

During the treatment for the prevention of hypovitaminosis should be used Vitamins B, K, brewer's yeast.

Tetracycline should not be taken concomitantly with milk and other dairy products. at the same time, absorption of the antibiotic is impaired.

Drug Interactions

Preparations containing metal ions (antacids, preparations containing iron, magnesium, calcium) form inactive chelates with tetracycline, therefore it is necessary to avoid their simultaneous appointment.

It is necessary to avoid the combination with penicillins, cephalosporins, which have bactericidal action and are antagonists of bacteriostatic antibiotics (including tetracycline).

With the simultaneous use of tetracycline with Retinol may develop intracranial hypertension.

When used simultaneously with colestyramine or colestipol, there is a violation of absorption of tetracycline.

Analogues of the drug Tetracycline

Structural analogs for the active substance:

• Tetracycline-AKOS;
• Tetracycline-LekT;
• Tetracycline hydrochloride.

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