Advantan - instructions for use, reviews, analogs and formulations (cream, ointment and emulsion 0.1%) of the drug for the treatment of dermatitis and eczema in adults, children (including newborns) and pregnancy. Composition of the hormonal agent
In this article, you can read the instructions for using the drug Advantan. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Advantan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Advantan in the presence of existing structural analogues. Use to treat dermatitis and eczema in adults, children (including newborns), as well as during pregnancy and lactation. Composition of hormonal means.
Advantan - Glucocorticosteroid (GCS) for external use, is a non-halogenated synthetic steroid (synthetic hormone). With external use, Advantan suppresses inflammatory and allergic skin reactions, as well as reactions associated with increased proliferation, which leads to a decrease in objective symptoms (erythema, edema, lichenification) and subjective sensations (itching, irritation, pain).
When applying methylprednisolone aceponate (active ingredient of the drug Advantan), the systemic effect is externally expressed minimally in both humans and animals. After repeated deposition Advantan on extensive surfaces (40-60% of the skin surface), as well as in the application under an occlusive dressing is not marked disorders of adrenal function: cortisol plasma level and its circadian rhythm remain within the normal range, reducing cortisol level in daily urine not occurs.
In clinical trials with the use of Advantan in the form of an ointment, cream, ointment or emulsion for up to 12 weeks in adults and up to 4 weeks in children (including the early age), there was no development of skin atrophy, telangiectasias, striae and acne vulgaris .
Methylprednisol aceponate (especially its main metabolite - 6alpha-methylprednisolone-17-propionate) binds to intracellular glucocorticoid receptors. The steroid-receptor complex binds to specific regions of DNA, thus causing a series of biological effects.
In particular, binding of the steroid-receptor complex to DNA leads to the induction of macrocortin synthesis. Macrocortin inhibits the release of arachidonic acid and, thereby, the formation of a mediator of inflammation such as prostaglandins and leukotrienes.
Inhibition of GCS synthesis of vasodilating prostaglandins and potentiation of vasoconstrictive action of epinephrine results in a vasoconstrictor effect.
Composition
Methylprednisolone aceponate + auxiliary substances.
Pharmacokinetics
The degree of percutaneous absorption depends on the condition of the skin, the dosage form and the method of administration (with or without occlusive dressing). When applying ointment, cream or oily ointment, percutaneous absorption in children and adults with atopic dermatitis (neurodermatitis) and psoriasis was not more than 2.5%, which is only slightly higher than in healthy volunteers (0.5-1.5%).
When using the preparation in the form of an emulsion, the intensity of absorption through the skin with artificial inflammation was very low (0.27%), which is only slightly higher than through healthy skin (0.17%). In case of treatment of the whole body (for example, with sunburn) the systemic dose is about 4 μg / kg of body weight per day (which excludes systemic effects).
Metabolites of methylprednisolone aceponate are excreted mainly by the kidneys.
Methylprednisolone aceponate and its metabolites are not cumulative in the body.
Indications
Ointment, cream, oily ointment
Inflammatory skin diseases, sensitive to therapy with topical SCS:
- atopic dermatitis, neurodermatitis, childhood eczema;
- true eczema;
- microbial eczema;
- Occupational eczema;
- dyshidrotic eczema;
- simple contact dermatitis;
- allergic (contact) dermatitis.
Emulsion for external use
Inflammatory skin diseases, sensitive to therapy with topical SCS:
- atopic dermatitis, neurodermatitis, childhood eczema;
- simple contact dermatitis;
- allergic (contact) dermatitis;
- true eczema;
- seborrheic dermatitis / eczema;
- microbial eczema;
- photodermatitis, sunburn.
Forms of release
Cream for external use 0.1%.
Ointment for external use 0.1%.
Ointment for external use fat 0.1%.
Emulsion for external use 0.1%.
Instructions for use and how to use them
Outwardly.
Adults and children from 4 months of the drug applied once a day, a thin layer on the affected skin.
Continuous daily application of Advantan in the form of a cream, ointment or oily ointment is for adults not more than 12 weeks, for children - not more than 4 weeks. The course of treatment with Advantan in the form of an emulsion is no more than 2 weeks.
The cream is a dosage form with a low fat content and a high water content, so it is recommended for subacute and acute inflammation without pronounced wetting. The cream provides elimination of the inflammatory process both on smooth skin and on the hairy part, incl. on the skin, prone to fat.
Ointment is a dosage form with a balanced ratio of fat and water, so it is recommended for subacute or chronic inflammatory skin diseases that are not accompanied by wetting. Ointment has a therapeutic effect, also helping to eliminate dry skin and restore its normal fat content.
Oily ointment is an anhydrous dosage form, therefore it is recommended for the treatment of prolonged chronic inflammatory skin processes with very dry skin. The occlusive effect of oily ointment provides a pronounced therapeutic effect even with significant lichenification and infiltration.
The emulsion is applied to the skin with a thin layer, lightly rubbing. With sunburn, the emulsion is applied 1-2 times a day. If the skin is excessively dry when using the emulsion, you must go to the drug form of Advantan with a higher fat content (ointment or oily ointment).
Side effect
- itching;
- burning;
- erythema;
- the formation of a vesicle rash;
- skin atrophy;
- telangiectasia;
- stria;
- acneiform skin changes;
- systemic effects due to absorption of the corticosteroid;
- folliculitis;
- hypertrichosis;
- perioral dermatitis;
- depigmentation of the skin;
- allergic reactions to one of the components of the drug.
Contraindications
- tuberculosis of the skin and skin manifestations of syphilis in the area of application of the drug;
- viral skin lesions in the area of application (for example, with chicken pox, shingles);
- rosacea, perioral dermatitis in the application area;
- skin manifestations of the reaction to vaccination;
- children's age up to 4 months;
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
If you need to use the drug Advantan during pregnancy and lactation, you should carefully weigh the expected benefit of therapy for the mother and the potential risk to the fetus or infant. During these periods, long-term use of the drug on extensive skin surfaces is not recommended.
Nursing mothers should not apply the drug to the mammary glands.
special instructions
In the presence of bacterial dermatoses and / or dermatomycosis, in addition to therapy with Advantan it is necessary to carry out specific antibacterial or antifungal treatment.
Avoid contact with the eyes.
As with systemic corticosteroids, glaucoma may develop with external application of GCS (for example, after high doses or very long-term use, the use of occlusive dressings or application to the skin around the eyes).
Impact on the ability to drive vehicles and manage mechanisms
Not found.
Drug Interactions
Drug interaction of the drug Advantan is not revealed.
Analogues of the drug Advantan
The Advantan has no structural analogs for the active substance.
Analogues containing methylprednisolone:
- Depot-Medrol;
- Lemodus;
- Medrol;
- Metizred;
- Solu-Medrol;
- Urbazon.
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