Fezam - instructions for use, reviews, analogs and forms of release (tablets, capsules 400 mg) drugs for the treatment of cerebral circulatory insufficiency in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Fezam. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Fezam in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Fezam in the presence of existing structural analogues. Use for the treatment of cerebral circulatory insufficiency in adults, children, as well as in pregnancy and breast-feeding. Composition.
Fezam - Combined drug with pronounced antihypoxic, nootropic and vasodilating action.
Pyracetam is a nootropic agent. Activates metabolic processes in the brain by enhancing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia. Improves interneuronal transmission in the central nervous system and regional blood flow in the ischemic zone.
Cinnarizine is a blocker of calcium channels. Inhibits the entry of calcium ions into cells and reduces their content in the depot of the plasmolemma. Reduces the tone of the smooth muscle arterioles, reduces their response to biogenic vasoconstrictors (adrenaline, norepinephrine, dopamine, angiotensin, vasopressin). Has a vasodilating effect (especially with respect to cerebral vessels, enhancing the antihypoxic effect of piracetam), without having a significant effect on blood pressure. It shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, increases the tone of the sympathetic nervous system. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces the viscosity of the blood.
Composition
Piracetam + cinnarizine + auxiliary substances.
Pharmacokinetics
Quickly and completely absorbed from the digestive tract. Pyracetam does not bind to plasma proteins. Penetrates into all organs and tissues, penetrates the placental barrier. Selectively accumulates in the cerebral cortex, mainly in the frontal, parietal and occipital lobes, the cerebellum and basal ganglia. Cinnarizine is actively and completely metabolized. Pyracetam is not metabolized. 1/3 metabolites are excreted in the urine, 2/3 - with feces.
Indications
- insufficiency of cerebral circulation (atherosclerosis of cerebral vessels, recovery period of ischemic and hemorrhagic strokes, after craniocerebral injuries, encephalopathy of various origins);
- intoxication;
- diseases of the central nervous system, accompanied by a decrease in intellectual-mnestic functions (memory, attention, mood);
- psychoorganic syndrome with symptoms of asthenia and adynamia;
- asthenic syndrome;
- labyrinthopathy;
- Meniere's syndrome;
- prevention of kinetosis;
- prevention of migraine;
- the lag of intellectual development in children.
Forms of release
Capsules 400 mg + 25 mg (sometimes mistakenly called tablets, but tablet forms of Fezam do not exist).
Instructions for use and dosing regimen
Adults prescribe 1-2 capsules 3 times a day for 1-3 months, depending on the severity of the disease. The course of treatment - 2-3 times a year.
Children older than 5 years are prescribed 1-2 capsules 1-2 times per day (no more than 3 months).
Side effect
- dyspepsia;
- headache;
- sleep disorders;
- allergic reactions in the form of skin rashes.
Contraindications
- severe violations of liver function;
- severe renal dysfunction;
- Parkinsonism;
- pregnancy;
- lactation (breastfeeding);
- children under 5 years;
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
Fezam is contraindicated in pregnancy and lactation.
special instructions
For renal insufficiency of mild and moderate severity (CC less than 60 ml / min), the therapeutic dose should be reduced or the interval between doses should be increased.
In patients with impaired liver function, it is necessary to monitor the content of liver enzymes.
Avoid drinking alcohol while taking Fezam.
Fezam should be administered with caution at increased intraocular pressure.
The drug can cause a positive reaction in athletes during the doping test, and also possible changes in the results of the determination of radioactive Iodine (the dyes in the shell of the capsule contain iodine).
Impact on the ability to drive vehicles and manage mechanisms
When taking the drug Fezam patients should be careful when driving vehicles and working with machines and equipment.
Drug Interactions
With simultaneous application with Fezam, it is possible to increase the sedative effect of drugs that depress the central nervous system, as well as ethanol (alcohol), nootropic and hypotensive drugs.
With the simultaneous use of vasodilators enhance the effect of Fezam.
Fezam improves the tolerability of antipsychotic drugs and tricyclic antidepressants.
Analogues of the medicament Fezam
Structural analogs for the active substance:
- Combbitropyl;
- NooCam;
- Omaron;
- Piracazine.
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