Thyreotom - instructions for use, reviews, analogues and form of release (tablets) of the drug for the treatment of hypothyroidism and goiter in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Thyreotome. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of thyrotomus in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of thyrotome in the presence of existing structural analogues. Use for the treatment of hypothyroidism and goiter in adults, children, as well as during pregnancy and lactation. Composition.

Thyreotome - a preparation of synthetic hormones of a thyroid gland.Replenishes the deficiency of thyroid hormones. Increases the need for tissues in oxygen, stimulates their growth and differentiation, increases the level of basal metabolism (proteins, fats and carbohydrates). In small doses anabolic, and in large - catabolic effect. Inhibits the production of thyroid-stimulating hormone. Strengthens energy processes, has a positive effect on the functions of the nervous and cardiovascular systems, the liver and kidneys.

Composition

Levothyroxine + lithotyronine + excipients.

Pharmacokinetics

When administered, levothyroxine is absorbed almost exclusively in the upper part of the small intestine. Absorbed up to 80% of the dose of the drug. Eating lowers the absorption of levothyroxine.

Thyroid hormones are metabolized mainly in the liver, kidneys, brain and muscles. A small amount of the drug is subjected to deamination and decarboxylation, as well as conjugation with sulfuric and glucuronic acids (in the liver). Metabolites are excreted in urine and bile.

Indications

• hypothyroidism;
• euthyroid goiter;
• as a replacement therapy and for the prevention of recurrence of goiter after resection of the thyroid gland;
• thyroid cancer (after surgical treatment);
• Diffuse toxic goiter: after reaching the euthyroid state with thyreostatics (in the form of combined therapy).

Forms of release

Pills.

Instructions for use and dosage

The daily dose is determined individually depending on the indications.

Hypothyroidism

Adults: treatment is started with 1 tablet of thyrotomol per day, then the dose can be increased by 1 tablet every 2-4 weeks until a maintenance daily dose of 2-5 tablets is reached.

Children: when choosing a dose for prolonged treatment, take into account the body weight, height and surface of the child's body. The average recommended maintenance dose is 2-2.5 thyrotoxic tablets per day.

Euthyroid goiter

Adults: the initial dose is 1-2 tablets per day, the maintenance dose is 3-6 tablets per day.

Adolescents: The initial dose is 1-1.5 tablets per day, the maintenance dose is 2.5-3.5 tablets per day.

Children: appoint 1 / 2-1 tablets per day.

Prophylaxis of goitre recurrence after surgical treatment

Adults appoint 2-3 tablets a day.

After surgical treatment for thyroid cancer, the initial dose is 3 tablets per day, maintaining a dose of 6 tablets per day.

The daily dose of the drug is taken once in the morning, at least 30 minutes before breakfast, without chewing and drinking with a sufficient amount of liquid.

The drug should be taken regularly.

The duration of treatment is determined by the form of the disease. As a rule, with hypothyroidism and after thyroidectomy for thyroid cancer treatment is carried out throughout life. Duration of use for euthyroid goiter, as well as for the prevention of recurrence of goiter after surgical treatment, ranges from several months or years to lifelong administration.

Side effect

• allergic reactions;
• progression of heart failure and angina pectoris.

Contraindications

• increased individual sensitivity to the drug;
• untreated thyrotoxicosis;
• acute myocardial infarction, angina 3-4 functional class;
• acute myocarditis;
• untreated adrenal insufficiency.

Application in pregnancy and lactation

During pregnancy and breastfeeding, thyroid hormone therapy prescribed for hypothyroidism should continue.During pregnancy, an increase in the dose of the drug is required due to an increase in the level of thyroxine-binding globulin.

The use of the drug in pregnancy in combination with thyreostatics is contraindicated, since it may be necessary to increase the doses of thyreostatics. Since thyreostatics, in contrast to levothyroxine, can penetrate the placenta, the fetus may develop hypothyroidism.

The number of thyroid hormones secreted with breast milk during lactation (even when treating with high doses of the drug) is not enough to cause any disturbances in the child. However, during breastfeeding, the drug should be taken with caution, strictly at recommended doses under the supervision of a doctor.

special instructions

When hypothyroidism, due to the pituitary lesion, it is necessary to find out whether there is a simultaneous insufficiency of the adrenal cortex. In this case, glucocorticosteroid replacement therapy should be started before thyroid hormone therapy begins to avoid hypothyroidism in order to avoid the development of acute adrenal insufficiency.

Impact on the ability to drive vehicles and manage mechanisms

The drug does not affect the professional activities associated with driving vehicles and controlling mechanisms.

Drug Interactions

Thyreotome enhances the effect of indirect anticoagulants, which may require a reduction in their dose.

The use of tricyclic antidepressants with Thyreotome may lead to an increase in the action of antidepressants.

Thyroid hormones can increase the need for insulin and oral hypoglycemic drugs. More frequent monitoring of blood glucose level is recommended to be carried out during the periods of starting treatment with the drug, as well as changing its dosage regimen.

Thyreotol reduces the action of cardiac glycosides.

With simultaneous application of colestramine, colestipol and aluminum hydroxide reduce the plasma concentration of the drug due to inhibition of its absorption in the intestine.

When used simultaneously with anabolic steroids, asparaginase, tamoxifen, pharmacokinetic interaction at the level of binding to the protein is possible.

With simultaneous use with phenytoin, salicylates, clofibrate, Furosemide in high doses (250 mg), the content of thyroid hormones unrelated to proteins of the blood plasma increases.

Admission of estrogen-containing drugs increases the content of thyroxine-binding globulin, which may increase the need for thyrotoxic in some patients. Somatotropin with simultaneous application with Thyreotome can accelerate the closure of epiphyseal growth zones.

The intake of phenobarbital, Carbamazepine and rifampicin may increase the clearance of levothyroxine and require an increase in the thyrotoxic dose.

Analogues of the drug Thyreotom

Structural analogs for the active substance:

• Novotiral.

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