En DE FR ES PL
De-Nol - instructions for use, analogs, reviews and release forms (tablets 120 mg) of a drug for the treatment of gastritis and stomach and duodenal ulcers in adults, children and in pregnancy

De-Nol - instructions for use, analogs, reviews and release forms (tablets 120 mg) of a drug for the treatment of gastritis and stomach and duodenal ulcers in adults, children and in pregnancy

In this article, you can read the instructions for using the drug De Nol. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of De-Nol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of De-Nol in the presence of existing structural analogs. Use for the treatment of gastritis and ulcers of the stomach and duodenum in adults, children, as well as during pregnancy and lactation.

 

De Nol - antiulcer drug with bactericidal activity against Helicobacter pylori. It also has an anti-inflammatory and astringent effect. Insoluble bismuth oxychloride and citrate are precipitated in the acidic environment of the stomach, and chelate compounds are formed with the protein substrate in the form of a protective film on the surface of ulcers and erosions.

 

Increasing the synthesis of prostaglandin E, the formation of mucus and the secretion of bicarbonate, stimulates the activity of cytoprotective mechanisms, increases the resistance of the gastrointestinal mucosa to the effects of pepsin, hydrochloric acid, enzymes and bile salts.

 

It leads to the accumulation of the epidermal growth factor in the defect area. Reduces the activity of pepsin and pepsinogen.

 

Pharmacokinetics

 

Bismuth titrate dicitrate (active ingredient of the drug De-Nol) is practically not absorbed from the digestive tract. It is excreted mainly with feces. An insignificant amount of bismuth, which enters the plasma, is excreted by the kidneys.

 

Indications

  • peptic ulcer of the stomach and duodenum in the phase of exacerbation (including associated with Helicobacter pylori);
  • chronic gastritis and gastroduodenitis in the phase of exacerbation (including associated with Helicobacter pylori);
  • irritable bowel syndrome, mainly with symptoms of diarrhea;
  • functional dyspepsia, not associated with organic gastrointestinal diseases.

 

Forms of release

 

Tablets coated with 120 mg.

 

Instructions for use and dosing regimen

 

Adults and children over 12 years of age the drug is prescribed 1 tablet 4 times a day for 30 minutes before meals and at night or 2 tablets 2 times a day for 30 minutes before meals.

 

Children aged 8 to 12 years are prescribed 1 tablet 2 times a day for 30 minutes before meals.

 

Children aged 4 to 8 years are prescribed at a dose of 8 mg / kg per day; The daily dose is divided into 2 doses. Take 30 minutes before meals.

 

Tablets should be washed down with a small amount of water.

 

The duration of the course of treatment is 4-8 weeks. For the next 8 weeks, do not take drugs containing bismuth.

 

For the eradication of Helicobacter pylori, it is advisable to use De-Nol in combination with antibacterial drugs possessing anti-Helicobacter pylori activity.

 

Side effect

  • nausea, vomiting;
  • increased frequency of stools;
  • constipation;
  • skin rash;
  • itching of the skin;
  • encephalopathy associated with the accumulation of bismuth in the central nervous system.

 

Contraindications

  • severe renal dysfunction;
  • pregnancy;
  • lactation period;
  • hypersensitivity to the drug.

 

Application in pregnancy and lactation

 

De-Nol is contraindicated for use during pregnancy and lactation.

 

special instructions

 

The drug should not be used for more than 8 weeks.

 

During treatment it is not recommended to exceed the established daily doses for adults and children.

 

During the De-Nol treatment period, other preparations containing bismuth should not be used.

 

At the end of the course treatment with the drug at recommended doses, the concentration of the active substance in the blood plasma does not exceed 3-58 μg / l, and intoxication is observed only at a concentration of more than 100 μg / l.

 

When De-Nol is used, it is possible to stain the stool black due to the formation of bismuth sulphide. Sometimes there is a slight darkening of the tongue.

 

Drug Interactions

 

With the simultaneous intake of other medicines, as well as food and liquids, in particular antacids, milk, fruits and fruit juices, it is possible to change the effectiveness of De-Nol (it is not recommended to take inside for 30 min before and after taking De-Nol).

 

Analogues of the drug De Nol

 

Structural analogs for the active substance:

  • Ventrisol;
  • Bismuth tricalcium dicitrate.

Similar medicines:

Other medicines:
Reviews (33):
Guests
gudgeon
Good preparation for treatment of gastric ulcer, especially in combination with antibiotics that kill H. pylori bacterium. Just have to be careful, and then de-nol colors chair in black and if a black chair zaiknetsya gastroenterologist, then hospitalization is provided - will look for internal bleeding from ulcers and bring a lot of inconvenience (check for yourself). This point should be borne in mind when taking de in tablets.
Guests
Alexey
Taken de zero with antibiotics to get rid of Helicobacter. Everything is normal, on the control probe decreased the number from three advantages to a plus sign (gastritniki-ulcer understand). True, the chair blackens strongly, but this doctor said the usual thing.Still there was a diarrhea periodic, but it more likely from antibiotics, without them in removal helikobaktera in any way while, painfully angry he became recently.
Guests
leonova.lari
So I did not finish the course, there were too many side effects, at least I have: nausea, and itching, and with a problem chair. About the effect I can not say, probably should be, but I refused the money.
Visitors
Seven-flower
To me appointed or nominated in a complex therapy at treatment of gastroduodenitis and helikobakter on 2 tablets 2 times a day. Of the characteristics of the drug - causes a darkening of the stool, this should be taken into account especially impressed people. After the course of treatment Helicobacter is not found and due to the deletion all small erosions have healed.
Guests
Dividing
I take 1.5 weeks, bitterness in the mouth, constipation, and a terribly black chair, but the pain completely disappeared.
Guests
Marrakech
And I'm delighted with the drug. With exacerbation of gastritis only they are saved. I drink a week, sparing food, and all the oxy))) About the pobochek - did not notice anything special.
Guests
Yura
When will they think up the drug for Helicobacter?
Administrators
admin
YuraEveryone is waiting for this - once drank and everything went away. But while there is no such, it is necessary to be treated by what is. And I will not say that it is inefficient - 80% of cases of Helicobacter infection are cured by existing therapy schemes.
Guests
Lubov Vasilevna
Accepted it, but for some reason I did not understand why she wrote it to me, because I did not do an analysis for Helicobacter, and the FGDS showed that I had tablets, I took ketonal and nyz, tk. the knee ached. After joints, made in the joint, the month was ok, and then just could not walk, and took painkillers, but not in bundles, but in Society. complexities of 7-10 pcs and erosion in the stomach, and all the mucous was inflamed, forgot that I drank in the first case, De-Nol, and Omez, and then the back got sick so I had to take Ibuprofen, and 2 months later again back and again Ibuprofen and again went to the FGD and besides erosion in the stomach, now was added an ulcer in the 12th finger and a hernia in the esophagus and something else in the gatekeeper that, more shortly again De-Nol and Maalox and Sunpresis or Omez, In short, I now again understand that I again do not order, tk.Heartburn me has tortured, and still the feeling of gravity in a stomach was added, as though there stones at me ...
Guests
Alice
A good preparation of a wide profile, to me it or him was appointed or nominated and at an erosive gastritis, and at gastroduodenitis. Of the features of the application - dark feces, otherwise only pluses.
Guests
Valentin Mazaev
The doctor prescribed Helicobacter pylori as a treatment, together with several types of medications, a whole mountain of tablets should be drunk every day. I can say that in the complex, De-nol showed himself a good medicine. The only thing that feces gets because of bismuth in it, black color and at first you can get scared. The stomach has stopped hurting, but not the fact that it is because of the De-Nol.
Guests
Larisa Anatolievna Shishkanova
A very good drug if you follow the rules on nutrition. I am being treated, I have a duodenal ulcer, I forget about it for 3 years. Do not relax and eat everything, yet the restriction should be if you do not want to suffer from pain. An excellent product.And do not look at the chair, the instructions say the same - there may be a discoloration.
Visitors
Light A
Tell me, please, whether it is possible to drink de vial simultaneously with omeprazole?
Administrators
admin
Light A, De-Nol can be used in some treatment regimens with omeprazole. According to the instructions and experience negative side effects from such a joint reception should not be.
Guests
viola
A good remedy for diseases of the gastrointestinal tract, relieves pain and spasms in the stomach, does not cause side effects. With the help of De-nol cured gastritis.
Guests
Екатерна
De-nol is a very good drug if you stick to a diet.
Guests
Magomed
I can not say anything yet. I only accept the second day. I have a question - to continue taking De-Nol, when the feces are painted black? Thank you.
Visitors
Eleka
Hello. Tell me, is it possible to take De-nol with reflux-esophagitis?
Administrators
admin
Eleka, Reflux esophagitis is a consequence of some process or disease. If this Helicobacter pylori-associated gastritis or ulcer-De-Nol is associated with a complex therapy, if it is organ damage to the esophagus and surrounding tissues (impaired patency, hernia, etc.), it will not help.
Visitors
Nazim
Hello. Can I take De-nol concomitantly with Omez for stomach treatment?
Administrators
admin
Magomed, Bismuth in the composition of De Nol can stain the stool black, it is also possible a darkening of the tongue. This is normal. The only danger is not to miss during this treatment bleeding from a stomach ulcer, in which it is also possible staining the stool to black.
Administrators
admin
Nazim, Can. The so-called quadrotherapy in anti-Helicobacter treatment is based on the use of two antibiotics, a proton pump inhibitor (say Omez) and bismuth preparations (De Nol).
Guests
Tatyana.
De Nol and Omeprazole can be taken concomitantly with an interval of 1 hour. Since De Nol suppresses the action of omeprazole. I read the rules of taking these medicines in the internet.
Guests
vera
Will de-nol be effective for treatment against Helicobacter without omeza and other antibacterial agents?
Administrators
admin
Tatyana., From your feedback, it turns out that De Nol and Omeprazole can not be taken together (one suppresses the action of another), in fact, a joint taking of these medications is possible. But to observe the interval to half an hour between taking these drugs is necessary.
Administrators
admin
vera, I have never seen such a thing in practice and literature. Helicobacter is a fairly stable bacterium and sometimes a complete antibacterial course does not lead to its complete destruction, it is necessary to repeat. Therefore, it is doubtful that one De Nol can cope with this infection.
Guests
lads
lads, Moved your feedback to the drug Pylobact, where it is more appropriate.
admin
Guests
a guest
In general, a couple of years ago there was an ulcer. Recently, my stomach began to ache. And what tablets to drink I do not know. It is necessary to go to see a doctor. Ask for a job. I shared with my mother, who is already 63 years old. Recently, he says De propyl nyl. She began to feel better. She to me - you want I'll buy you. Well free for the same. I agreed. I drank the drug. Day on the fifth like the stomach calmed down.
On the sixth day, there was pressure in the heart. Before that, for half a year, something seriously poddavlivalo. Has not connected with De-nol. On the seventh, everything was still pressing, the indisposition did not stop. I went to the ambulance by car, from the house not far, on foot a couple of minutes, but the ice in the late evening is hard to go. In the ambulance did a cardiogram, said a small change. They said that it looks like preinfarction, they pumped morphine, heparin, tablets from blood clots gave 4 pieces. You must take you to the clinic to see the therapist. Cardiologists are not on duty with us. I'm good. I called my wife, explained everything, I left her keys in the ambulance from the car, and myself in the intensive care unit to the hospital. We arrived and took blood.The therapist has looked or seen analyzes and me - admit the day before used? And I to her I two months as do not drink and I do not smoke. The stomach is naughty. It is according to your analysis that the liver falls off. In general, put. For two days I was already in a hospital. Let go. Made fgs. (to all the cores do, ask friends who were lying) FGS showed an erosive gastritis. To the treating cardiologist I speak let's De-nol I will have a drink. I still have left. In an idiot. Began to drink again. The day after the fourth was laid. I slept for a week. Because I felt great. The doctor appointed a survey for coronography in Krasnoyarsk. Turn for a month. In short, I was discharged, but the next day at work again presses. At this point my doubts disappeared. I do not drink the second day today, from dinner, let go. Today there are no drugs at all.
Wife yesterday you are some kind of gray and depressed. I really felt like a corpse. I shared my thoughts on De-nol with her and that I will not drink it. Today she talked to her friend on the phone and about my health in particular, she said for De-nol, and that she, and so my friend (she is single) also with a stomach could be so weak from the denol did not die. I do not know how he died there, but what was bad for him could even be worse than me.
Before this, the ulcer treated with boiled water interfered with the starch and added a few drops of iodine, disgusting, but effective. Now potatoes rub on a grater I add a drop of iodine diluted with water.
In Contra-indications on De-nol anything serious do not write. They lie in secret. The girl here laid out which bismuth poison contained in the drug.
One plus will do coronography.
Treated folk remedies. Cheap and efficient
After lying in the hospital, many people ask why? And it turns out not a few people are found who took this drug and everything was bad to some extent and ineffectively.
Guests
Irina
Thanks for the feedback, I will now take de-nol and omeprazole. If the stomach aches a bit, then there must be Helicobacter? I was prescribed de-nol, but did not take tests. If I drink it will not hurt?
Administrators
admin
Irina, The stomach can hurt for hundreds of reasons. The Helicobacter pylori bacterium does not cause any symptoms in patients who are infected with it, the symptoms that cause the life of this microorganism (gastritis, ulcer, etc.) cause symptoms.
Guests
Sabrina
I take a little over a week. Pain decreased. On a follow-up examination, it will be seen whether this treatment helped.
Guests
Guest of Vera
Irina, in some cases, a doctor can prescribe a treatment based on symptoms. He did a survey, held his palpation? So that was enough. From the fact that you will drink the de-nol on the prescription of the doctor, there will be no harm, he will restore the mucous membrane and due to the fact that he possesses bactericidal activity he will clean the pathogenic flora. Only during the intake, follow the instructions and do not use milk, fruit and fruit juices at the same time. In occasion of omeprazole it is necessary to consult with the doctor, in some cases if it is not necessary, IPPs are not prescribed. In occasion of heliko, it is not obligatory to eat, if the stomach hurts, there are illnesses or diseases GASTROINTESTINAL TRACT even on a background of stresses, it is a lot of reasons.
Guests
lemon
A wonderful drug, he helped me a lot.

Rules for publishing reviews and visitor questions