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Omeprazole - instructions for use, analogs, reviews and release forms (capsules 10 mg, 20 mg, 40 mg) of the drug for the treatment of gastritis and peptic ulcer of the stomach and duodenum in adults, children and during pregnancy

Omeprazole - instructions for use, analogs, reviews and release forms (capsules 10 mg, 20 mg, 40 mg) of the drug for the treatment of gastritis and peptic ulcer of the stomach and duodenum in adults, children and during pregnancy

In this article, you can read the instructions for using the drug Omeprazole. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Omeprazole in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of omeprazole in the presence of existing structural analogues. Use for the treatment of gastritis and peptic ulcer of the stomach and duodenum in adults, children, as well as during pregnancy and lactation.

 

Omeprazole proton pump inhibitor.Reduces acid production - inhibits the activity of H + / K + ATPase in parietal cells of the stomach and blocks, thus, the final stage of secretion of hydrochloric acid.

 

Reduces basal and stimulated secretion irrespective of the nature of the stimulus. The antisecretory effect after taking 20 mg occurs within the first hour, a maximum after 2 hours. Inhibition of 50% of maximum secretion lasts 24 hours.

 

A single dose per day provides fast and effective suppression of day and night gastric secretion, reaching its maximum after 4 days of treatment and disappearing by the end of 3-4 days after the end of the admission. In patients with duodenal ulcer, taking 20 mg of omeprazole maintains an intragastric pH of 3 for 17 hours.

 

Pharmacokinetics

 

Absorption is high. Almost completely metabolized in the liver with the formation of 6 metabolites (hydroxyomeprazole, sulfide and sulfone derivatives and others), pharmacologically inactive. Kidney excretion (70-80%) and with bile (20-30%).

 

Indications

  • peptic ulcer of the stomach and duodenum (including the prevention of relapses);
  • reflux esophagitis;
  • hypersecretory conditions (Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, polyendocrine adenomatosis, systemic mastocytosis);
  • NSAIDs-gastropathy;
  • eradication of Helicobacter pylori in infected patients with peptic ulcer of the stomach and duodenum (as part of combination therapy).

 

Forms of release

 

Capsules soluble in the intestines 10 mg, 20 mg and 40 mg.

 

Instructions for use and dosing regimen

 

Individual. When administered orally, a single dose of 20-40 mg. The daily dose is 20-80 mg; Frequency of application - 1-2 times a day. Duration of treatment is 2-8 weeks.

 

Inside, squeezed with a small amount of water (the contents of the capsule can not be chewed).

 

Peptic ulcer of duodenum in the phase of exacerbation - 1 caps. (20 mg) per day for 2-4 weeks (in resistant cases - up to 2 capsules per day).

 

Stomach ulcer in the phase of exacerbation and erosive-ulcerative esophagitis - 1-2 caps. per day for 4-8 weeks.

 

Erosive-ulcerative lesions of the gastrointestinal tract caused by the intake of NSAIDs - 1 caps. per day for 4-8 weeks.

 

Eradication Helicobacter pylori - 1 caps. 2 times a day for 7 days in combination with antibacterial agents.

 

Antrepid treatment of peptic ulcer of the stomach and duodenum - 1 caps. per day.

 

Antrepid treatment of reflux esophagitis - 1 caps.per day for a long time (up to 6 months).

 

Zollinger-Ellison syndrome - the dose is selected individually depending on the initial level of gastric secretion, usually from 60 mg / day. If necessary, the dose is increased to 80-120 mg / day, in this case it is divided into 2 divided doses.

 

Side effect

  • nausea;
  • diarrhea, constipation;
  • stomach ache;
  • flatulence;
  • headache;
  • dizziness;
  • weakness;
  • anemia, eosinopenia, neutropenia, thrombocytopenia;
  • hematuria, proteinuria;
  • arthralgia;
  • muscle weakness;
  • myalgia;
  • skin rash.

 

Contraindications

  • chronic liver diseases (including in history);
  • increased sensitivity to omeprazole.

 

Application in pregnancy and lactation

 

Due to the lack of clinical experience, omeprazole is not recommended for use in pregnancy. If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.

 

special instructions

 

Before the start of therapy, it is necessary to exclude the possibility of the presence of a malignant process (especially with gastric ulcer), because Treatment with omeprazole can mask symptoms and delay correct diagnosis.

 

Against the background of the use of omeprazole, the results of laboratory tests of liver function and gastrin concentration in the blood plasma may be distorted.

 

Use in Pediatrics

 

Due to the lack of clinical experience, omeprazole is not recommended for use in children.

 

Drug Interactions

 

At simultaneous application with atrakury besylate the effects of atracurium besylate are prolonged.

 

When used simultaneously with bismuth, tricalium dicitrate, an undesirable increase in the absorption of bismuth is possible.

 

With simultaneous use with digoxin, a slight increase in the concentration of omeprazole in the blood plasma is possible.

 

With simultaneous use with disulfiram, a case of impaired consciousness and catatonia has been described; with indinavir - a decrease in the concentration of indinavir in blood plasma; with Ketoconazole - a decrease in the absorption of ketoconazole.

 

With prolonged simultaneous use with clarithromycin, there is an increase in the concentrations of omeprazole and Clarithromycin in the blood plasma.

 

The cases of decreasing the excretion of Methotrexate from the body in patients receiving omeprazole are described.

 

With simultaneous application with theophylline, a slight increase in the clearance of theophylline is possible.

 

It is believed that with the simultaneous use of omeprazole in high doses and phenytoin, an increase in the concentration of phenytoin in the blood plasma is possible.

 

Cases of increasing the concentration of cyclosporine in the blood plasma are described when used simultaneously with cclosporin.

 

At simultaneous application with Erythromycin the case of increase in concentration of an omeprazole in a blood plasma is described, thus efficiency of an omeprazole decreased.

 

Analogues of the drug Omeprazole

 

Structural analogs for the active substance:

  • Vero-Omeprazole;
  • Gastrozole;
  • Demeprazole;
  • Zhelezolic;
  • A zerocide;
  • Zolser;
  • Chrismel;
  • Losek;
  • Losek MAPS;
  • Omez;
  • Omez Insta;
  • Omesol;
  • Omekaps;
  • Omeprazole Sandoz;
  • Omeprazole-AKOS;
  • Omeprazole-Acry;
  • Omeprazole-Richter;
  • Omeprazole-FPO;
  • Omepros;
  • Omeface;
  • Omizak;
  • OmiPix;
  • Omitox;
  • Ortanol;
  • Ozid;
  • Pepticum;
  • Pleom-20;
  • Pomez;
  • Romesque;
  • Ulzol;
  • Ulcozol;
  • Ultop;
  • Helicid;
  • Helol;
  • Cisagast.

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Reviews (19):
Guests
gastritis
A good drug. He helped me with a stomach ulcer. Had in his passive surgery for perforation of the ulcer, he was treated with many variants of omeprazole, from expensive to the cheapest, but the difference in them was not particularly felt. So you do not need to overpay, you are treated with usual capsules of usual Omeprazole, the result will be the same as from expensive analogues.
Guests
Karine
Tried, helps.
Guests
Vadim
From heartburn helped.
Guests
Yuri
The drug is wonderful, after the course of taking two weeks, this is the third month as there is no heartburn. And it was the case that heartburn tormented almost every day and not one decade. I eat everything.
Guests
Olga
I see how everyone praises omeprazole, I want to add that sort of my spoon of tar. At me often in the spring there are exacerbations - the stomach hurts. The diagnosis of erosive gastritis has been put for several years. Last year, the doctor prescribed this drug, well helped, the pain disappeared pretty quickly, and I safely forgot about my gastritis until this spring.Decided again to resort to it, as always - 1 capsule once a day before breakfast. I drank three days, but on the 4th .. this, I must say, was a real horror - what was happening to my face and the skin of my hands! A red rash was everywhere! It was necessary to sit down on the sick leave and treat the allergy, which caused omeprazole, which I think even now I'm afraid.
Guests
galena
Thanks for the feedback. I'll try for heartburn.
Guests
Clara
I was also prescribed omeprazole in capsules, after the first application a terrible allergy was poured out, that it is not possible to fall asleep for several days.
Visitors
Raisa
Good afternoon. I had a nausea and I passed the EGF, because stood on record with an atrophic gastritis. To me have diagnosed Superficial gastroduodenitis moderately expressed. I started treatment according to the doctor's prescription: amoxicillin, clarithromycin, omez 1 ton. 2 times a day for 2 weeks, motilac - 5 days. On the 5th day, pains began in the stomach. Has recovered, has passed anew FGDS, since. pain did not pass, depression, pressure, insomnia were added.The result: the stomach contains mucus, bright pink, shiny, edematous. Bulb 12 p / to - mucous bright pink, edematous. The diagnosis is superficial gastroduodenitis. The conclusion of US - an anomaly of the form of a gall bladder, an inflection of a body z.p. Assigned: afobazol, glycine, motilium and chamomile. OA blood and biochemistry are within normal limits. The pain remained. We do not take a biopsy (or do not want to take). The pressure itself coped with mint (one minus - belching sour in the mouth). Now I was prescribed De-Nol on 2t 2 times a day, Ursosan for the night - 3 months and Omeprazole for 1t. 2 times a day for 2 weeks. My question is this: Is Omega and Omeprazole the same medicine? There are rare acute pains in the lower abdomen on the left (I think the intestine can). The chair returned to normal. Acidity does not determine us. Why do pains last so long? And what kind of examination can I still go through (we have physicians therapists all after the institute just now)? Thank you so much.
Administrators
admin
RaisaOf course, to make a biopsy and determine helikobakter are obliged, these are the standards of world medicine, without this you can only guess whether you have a Helicobacter pylori bacterium or not, and this bacterium is the main factor in provoking gastritis or stomach and duodenal ulcers.You can make a blood test for helikobakter (usually taken in paid medical centers), also a fairly predictive analysis. I do not prescribe the respiratory urease test for Helicobacter primarily, it can show incorrect results, which will be misinterpreted. The result is to understand if you have helikobakter or not and treat it repeatedly, if the tests confirm the presence of bacteria in the body.

Omez and Omeprazole are analog preparations, contain the same active substance - omeprazole. So the difference between them will not be special and the effects should be similar.

Ursosan was prescribed correctly, because it is possible that bile stagnates because of an inflection. If there are no stones in the gallbladder and ducts, you can recommend still poprinimat Holosas or other choleretic preparations to expel the bile stagnant in the bladder and in this moment to ease the condition.

In general, with a gastroenterologist you should communicate tightly, because I see a few problems and so far the final diagnosis is not going. It is necessary дообследоваться and to recover.
Visitors
Raisa
Thank you very much for the answer.
Guests
Olga
Omeprazole helps me very well for heartburn. I used to take ranitidine, it also very quickly and relieves heartburn, but my hair falls out heavily, so I switched to omeprazole. Of side effects, there is sometimes swelling and increased gas formation.
Guests
derevce
I have an ulcer bulb. Have registered a vent, but it can not be bought. Can I replace omeprazole and how to take it?
Administrators
admin
derevce, In occasion of such replacements it is necessary to address to the attending physician because Omeprazole and Venter different preparations and medical effects in groups are also different, although they can be used to treat the same diseases. An ulcer is serious. Venter - a gastroprotective agent, forms a protective layer on the gastric mucosa, leading to ulcer healing. Omeprazole is an inhibitor of the proton pump, reduces the secretion of hydrochloric acid and also contributes to cicatrization of the ulcer. I would prescribe both of these drugs and it is possible that you were prescribed.
Guests
Vera Kapmakova
I have a hernia of the esophagus, heartburn practically does not pass. Will omeprazole help me?
Administrators
admin
Vera Kapmakova, Of oestrus hernia omeprazole, of course, will not relieve, but as a symptomatic remedy for heartburn should help. The course for 1 month for 30 minutes before a meal can poprinimat for a start. Then you can add (in the case of primary therapy effectiveness) on demand weekly courses, when heartburn will manifest.
Guests
Galina
Dear, the administrator. And how to take omeprazole - before, during or after a meal? In the annotation, nothing about this is written. Thank you.
Administrators
admin
Galina, Already more than once answered here this question. Omeprazole is taken in the morning 30 minutes before meals.
Tell me, please, what are the differences between omez and omeprazole? Which of these two drugs can be better suited for diagnoses of hypertension, angina pectoris, stenosis, gallstones, age 76? I'm not asking for self-treatment.
Administrators
admin
Natalia 08042015, None. The difference is only in personal prejudices and producers, but these funds help in the same way. If pobochka will be on Omeprazole, then at 95% I can say that it will be on Omez.

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