Omeprazole - instructions for use, analogs, reviews and release forms (capsules 10 mg, 20 mg, 40 mg) of the drug for the treatment of gastritis and peptic ulcer of the stomach and duodenum in adults, children and during pregnancy
In this article, you can read the instructions for using the drug Omeprazole. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Omeprazole in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of omeprazole in the presence of existing structural analogues. Use for the treatment of gastritis and peptic ulcer of the stomach and duodenum in adults, children, as well as during pregnancy and lactation.
Omeprazole proton pump inhibitor.Reduces acid production - inhibits the activity of H + / K + ATPase in parietal cells of the stomach and blocks, thus, the final stage of secretion of hydrochloric acid.
Reduces basal and stimulated secretion irrespective of the nature of the stimulus. The antisecretory effect after taking 20 mg occurs within the first hour, a maximum after 2 hours. Inhibition of 50% of maximum secretion lasts 24 hours.
A single dose per day provides fast and effective suppression of day and night gastric secretion, reaching its maximum after 4 days of treatment and disappearing by the end of 3-4 days after the end of the admission. In patients with duodenal ulcer, taking 20 mg of omeprazole maintains an intragastric pH of 3 for 17 hours.
Pharmacokinetics
Absorption is high. Almost completely metabolized in the liver with the formation of 6 metabolites (hydroxyomeprazole, sulfide and sulfone derivatives and others), pharmacologically inactive. Kidney excretion (70-80%) and with bile (20-30%).
Indications
- peptic ulcer of the stomach and duodenum (including the prevention of relapses);
- reflux esophagitis;
- hypersecretory conditions (Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, polyendocrine adenomatosis, systemic mastocytosis);
- NSAIDs-gastropathy;
- eradication of Helicobacter pylori in infected patients with peptic ulcer of the stomach and duodenum (as part of combination therapy).
Forms of release
Capsules soluble in the intestines 10 mg, 20 mg and 40 mg.
Instructions for use and dosing regimen
Individual. When administered orally, a single dose of 20-40 mg. The daily dose is 20-80 mg; Frequency of application - 1-2 times a day. Duration of treatment is 2-8 weeks.
Inside, squeezed with a small amount of water (the contents of the capsule can not be chewed).
Peptic ulcer of duodenum in the phase of exacerbation - 1 caps. (20 mg) per day for 2-4 weeks (in resistant cases - up to 2 capsules per day).
Stomach ulcer in the phase of exacerbation and erosive-ulcerative esophagitis - 1-2 caps. per day for 4-8 weeks.
Erosive-ulcerative lesions of the gastrointestinal tract caused by the intake of NSAIDs - 1 caps. per day for 4-8 weeks.
Eradication Helicobacter pylori - 1 caps. 2 times a day for 7 days in combination with antibacterial agents.
Antrepid treatment of peptic ulcer of the stomach and duodenum - 1 caps. per day.
Antrepid treatment of reflux esophagitis - 1 caps.per day for a long time (up to 6 months).
Zollinger-Ellison syndrome - the dose is selected individually depending on the initial level of gastric secretion, usually from 60 mg / day. If necessary, the dose is increased to 80-120 mg / day, in this case it is divided into 2 divided doses.
Side effect
- nausea;
- diarrhea, constipation;
- stomach ache;
- flatulence;
- headache;
- dizziness;
- weakness;
- anemia, eosinopenia, neutropenia, thrombocytopenia;
- hematuria, proteinuria;
- arthralgia;
- muscle weakness;
- myalgia;
- skin rash.
Contraindications
- chronic liver diseases (including in history);
- increased sensitivity to omeprazole.
Application in pregnancy and lactation
Due to the lack of clinical experience, omeprazole is not recommended for use in pregnancy. If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.
special instructions
Before the start of therapy, it is necessary to exclude the possibility of the presence of a malignant process (especially with gastric ulcer), because Treatment with omeprazole can mask symptoms and delay correct diagnosis.
Against the background of the use of omeprazole, the results of laboratory tests of liver function and gastrin concentration in the blood plasma may be distorted.
Use in Pediatrics
Due to the lack of clinical experience, omeprazole is not recommended for use in children.
Drug Interactions
At simultaneous application with atrakury besylate the effects of atracurium besylate are prolonged.
When used simultaneously with bismuth, tricalium dicitrate, an undesirable increase in the absorption of bismuth is possible.
With simultaneous use with digoxin, a slight increase in the concentration of omeprazole in the blood plasma is possible.
With simultaneous use with disulfiram, a case of impaired consciousness and catatonia has been described; with indinavir - a decrease in the concentration of indinavir in blood plasma; with Ketoconazole - a decrease in the absorption of ketoconazole.
With prolonged simultaneous use with clarithromycin, there is an increase in the concentrations of omeprazole and Clarithromycin in the blood plasma.
The cases of decreasing the excretion of Methotrexate from the body in patients receiving omeprazole are described.
With simultaneous application with theophylline, a slight increase in the clearance of theophylline is possible.
It is believed that with the simultaneous use of omeprazole in high doses and phenytoin, an increase in the concentration of phenytoin in the blood plasma is possible.
Cases of increasing the concentration of cyclosporine in the blood plasma are described when used simultaneously with cclosporin.
At simultaneous application with Erythromycin the case of increase in concentration of an omeprazole in a blood plasma is described, thus efficiency of an omeprazole decreased.
Analogues of the drug Omeprazole
Structural analogs for the active substance:
- Vero-Omeprazole;
- Gastrozole;
- Demeprazole;
- Zhelezolic;
- A zerocide;
- Zolser;
- Chrismel;
- Losek;
- Losek MAPS;
- Omez;
- Omez Insta;
- Omesol;
- Omekaps;
- Omeprazole Sandoz;
- Omeprazole-AKOS;
- Omeprazole-Acry;
- Omeprazole-Richter;
- Omeprazole-FPO;
- Omepros;
- Omeface;
- Omizak;
- OmiPix;
- Omitox;
- Ortanol;
- Ozid;
- Pepticum;
- Pleom-20;
- Pomez;
- Romesque;
- Ulzol;
- Ulcozol;
- Ultop;
- Helicid;
- Helol;
- Cisagast.
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