Sifloks - instructions for use, reviews, analogs and forms of release (tablets 250 mg and 500 mg) of a drug for the treatment of angina, bronchitis, otitis and cystitis in adults, children and pregnancy. Composition of antibiotic and alcohol

In this article, you can read the instructions for using the drug Sifloks. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of antibiotic Siflox in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Siflox in the presence of existing structural analogs. Use for the treatment of angina, bronchitis, otitis and cystitis in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Sifloks - a synthetic antibacterial agent of a broad spectrum of action from the group of fluoroquinolones. Ciprofloxacin (active ingredient of Siflox) It is highly effective against virtually all gram-negative and gram-positive pathogens (Pseudomonas, Haemophilus and Escherichia coli, Shigella, Salmonella, meningococcus, gonococcus, staphylococcus many strains, some enterococci and Campylobacter, Legionella, Mycoplasma, Chlamydia, mycobacteria). Does not affect gram-negative anaerobic bacteria (Bacteroides), spirochetes.

Composition

Ciprofloxacin hydrochloride + excipients.

Pharmacokinetics

When taken orally, Siflox is rapidly absorbed from the gastrointestinal tract. Bioavailability of the drug is on average 70%. The degree of binding to plasma proteins is 30%.

After oral drug readily crosses the tissue and fluid, reaching the highest concentration in the bile, lung, kidney, liver, gall bladder, uterus, semen, prostate tissue and fluids, tonsils, endometrium, fallopian tubes and ovaries. Ciprofloxacin is also well distributed in bones, watery eyes, bronchial secretions,saliva, nasal secretions, skin, muscles, fatty tissues, cartilage, pleura, lymph and fluid in the abdominal cavity. Siflox accumulates in blood neutrophils, penetrates into the cerebrospinal fluid in small amounts.

The half-life is approximately 4 hours, 50-70% of the drug is excreted in urine and 15-30% is excreted with feces.

Indications

• angina or tonsillitis (inflammation of the tonsils);
• otitis media (inflammation of the middle ear);
• sinusitis or sinusitis (inflammation of the paranasal sinuses);
• mastoiditis (inflammation of the mastoid process of the temporal bone);
• nasopharyngitis (inflammation of the nasopharyngeal mucosa);
• laryngotracheitis (inflammation of the mucous larynx and trachea);
• bronchitis (inflammation of bronchial mucosa);
• pneumonia (pneumonia);
• urethritis (inflammation of the mucous urethra);
• cystitis (inflammation of the bladder);
• pyelonephritis (inflammation of the renal pelvis);
• prostatitis (inflammation of the prostate gland);
• adnexitis (inflammation of the ovaries and fallopian tubes);
• endometritis (inflammation of the mucous membrane of the uterus);
• gonorrhea (venereal disease);
• osteomyelitis (purulent-necrotic process in the bone);
• septic arthritis (purulent inflammation of the joint);
• peritonitis (inflammation of the peritoneum);
• septicemia (ingress of bacteria into the bloodstream);
• Cholangitis and cholecystitis (inflammation of the biliary tract and gallbladder);
• infections of the skin and soft tissues;
• dental infection.

Forms of release

Tablets coated with 250 mg and 500 mg.

Instructions for use and dosing regimen

Inside, with uncomplicated infections of the urinary tract - 250 mg 2 times a day. In severe infections of the urinary tract - 500 mg 2 times a day. In severe infections of the respiratory tract and osteomyelitis - 750 mg 2 times a day. At other infections - on 500 mg 2 times a day, at an acute gonorrhea - once 250 mg. The course of treatment: gonorrhea - 1 day, kidney and urinary tract infections - 7-10 days, streptococcal infections - at least 10 days. Usually treatment is continued for 72 hours after clinical and microbiological recovery.

Side effect

• nausea, vomiting;
• diarrhea;
• lack of appetite;
• gastrointestinal bleeding;
• headache;
• dizziness;
• hallucinations;
• irritability;
• insomnia;
• skin rashes, itching;
• swelling of the tongue and throat;
• nose bleed;
• dyspnea;
• angina (attack of pain in the heart);
• a feeling of palpitations;
• paroxysmal tachycardia (a sharp increase in heart rate);
• arterial hypertension;
• migraine;
• arthralgia (joint pain);
• noise in ears;
• loss of hearing;
• diplopia (double vision);
• increased photosensitivity;
• retention of urination;
• eosinophilia (increase in the number of eosinophils in the blood);
• leukopenia or leukocytosis;
• increased level of transaminases (liver enzymes);
• increase in the level of alkaline phosphatase in the blood;
• Crystalluria (crystals of salts in the urine).

Contraindications

• hypersensitivity to the components of the drug;
• age to 18 years;
• pregnancy;
• the period of breastfeeding.

Carefully:

• pronounced atherosclerosis of cerebral vessels;
• impaired cerebral circulation;
• mental illness;
• epilepsy;
• epileptic syndrome;
• marked renal or hepatic insufficiency;
• elderly age.

Application in pregnancy and lactation

Siflox is contraindicated in pregnancy, during lactation.

Use in children

Contraindicated in children and adolescents under the age of 18 years.

Application in elderly patients

Care should be taken when applying in old age.

special instructions

Siflox can cause a reaction from the CNS in the form of tremors, tension, dizziness, confusion, hallucinations and seizures in rare cases. In this regard, Siflox should be used with caution in patients with CNS disorders. In patients with seizures in the history of Siflox can be used only against the background of adequate anticonvulsant therapy.

Cases of polyneuropathy (based on neurologic symptoms, such as pain, burning, sensory disorders, or muscle weakness, alone or in combination) were seen in patients receiving Siflox. It is necessary to cancel the drug in patients with symptoms of neuropathy (pain, burning, tingling, numbness, weakness) in order to prevent the development of irreversible disorders.

Therapy with quinolones can be associated with hypersensitivity reactions that can develop even after a single dose of the drug. Therapy with Siflox should be stopped at the first sign of an allergic reaction.

As with other broad spectrum antimicrobial agents, prolonged use of Siflox may lead to increased growth of insensitive microorganisms and superinfection.

With prolonged therapy, periodic assessment of the function of vital organs and systems (kidney, liver and hematopoiesis) is recommended. To prevent crystalluria should ensure the intake of liquid in sufficient quantities.

Impact on the ability to drive vehicles and manage mechanisms

Siflox can cause a weakening of attention and reaction, so patients taking Siflox should be limited to activities related to the need for rapid concentration of attention and high reactivity.

Drug Interactions

Antatsidy containing aluminum and magnesium, can reduce the level of absorption of the drug Sifloks. Metoclopramide accelerates the absorption of Siflox.

Simultaneous reception of Siflox with Teofillin, Methotrexate, Glibenclamide, Tizanidine, Duloxetine, Ropinirole raises the plasma level in the blood of the latter. Siflox lowers the clearance of Caffeine and may increase the half-life of the serum.

The combined use of probenecid and Siflox increases the concentration of antibiotic in the blood plasma.

Simultaneous application of Siflox and Omeprazole leads to a slight decrease in the maximum plasma concentration and the average concentration in the urine of Siflox.

Simultaneous use of Siflox, aminoglycosides, beta-lactam antibiotics gives an additive and synergistic effect.

Simultaneous use of Siflox with vitamin K antagonists can enhance its anticoagulant effect.

Alcohol can increase the chance of side effects.

Analogues of the drug Sifloks

Structural analogs for the active substance:

• Afenoxin;
• Basijen;
• Betaciprol;
• Zindolin 250;
• Isfipro;
• Quintor;
• Quipro;
• Liprokhin;
• Microfleks;
• Nirtsip;
• Oftotsipro;
• PROCIPRO;
• Recipro;
• Rozip;
• Ceprova;
• Ciloxane;
• Cipronol;
• Ciprobay;
• Ciprobide;
• Ciprobrin;
• Citrodox;
• Ciproxyl;
• Tsiprolet;
• Ciprolone;
• Cipromed;
• Cipropane;
• Ciprosan;
• Ciprosine;
• Ciprofloxacin;
• Cytar;
• Cifloxinal;
• Tsifran;
• Cyphrazide;
• Ecocylol.

Response of infectious diseases physician

Sifloks is an antibiotic of Turkish origin, belongs to the group of second generation fluoroquinolones. Its advantages are a wide spectrum, activity against the majority of gram-positive and gram-negative microorganisms. In addition, antibiotics based on ciprofloxacin, including Siflox, destroy intracellular parasites, and can be used to treat infections caused by chlamydia and mycoplasmas.Of the disadvantages - the inability to prescribe during pregnancy and childhood, the risk of use in epilepsy and in old age. Sifloks are often prescribed for the treatment of pneumonia in combination with carbapenems, especially if the pathogen is Pseudomonas aeruginosa. But, if you choose from the group of fluoroquinolones, it is better to give preference to the "respiratory" antibiotics of the third and fourth generation (Levofloxacin, Moxifloxacin), since they are also effective against pneumococci.

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