Ciprolet - instructions for use, analogs, reviews and release forms (tablets 250 mg and 500 mg, eye drops, injections in injections) of a drug for the treatment of angina, cystitis and other infections in adults, children and pregnancy
In this article, you can read the instructions for using the drug Tsiprolet. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Ciprolet in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ciprolet in the presence of existing structural analogs. Use for the treatment of angina, sinusitis, cystitis and other infectious diseases in adults, children,as well as during pregnancy and lactation.
Tsiprolet - antibacterial preparation of a wide spectrum of action from the group of fluoroquinolones. It is bactericidal. The drug inhibits the DNA enzyme enzyme of bacteria, as a result of which DNA replication and the synthesis of bacterial cell proteins are disturbed. Ciprofloxacin (the active substance of the drug Tsiprolet) acts both on multiplying microorganisms, and on those in the resting phase.
Ciprofloxacin susceptible gram-negative and gram-positive bacteria and some intracellular pathogens: Legionella pneumophila, Brucella spp, Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium-intracellulare.. The majority of staphylococci, resistant to methicillin, are resistant to ciprofloxacin.
The sensitivity of bacteria Streptococcus pneumoniae, Enterococcus faecalis is moderate.
To a drug resistant Corynebacterium spp., Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. The effect of the drug against Treponema pallidum has not been adequately studied.
Pharmacokinetics
When taken orally, Ciprolet is rapidly absorbed from the digestive tract. Orally taken ciprofloxacin is distributed in tissues and body fluids. High drug concentrations are observed in bile, lung, kidney, liver, gall bladder, uterus, semen, prostate tissue, tonsils, endometrium, fallopian tubes and ovaries. The concentration of the drug in these tissues is higher than in the serum.Ciprofloxacin also penetrates well into the bones, eye fluid, bronchial secretion, saliva, skin, muscles, pleura, peritoneum, lymph. In the cerebrospinal fluid the drug penetrates in a small amount, where its concentration is 6-10% of that of serum.
The main way to remove ciprofloxacin from the body through the kidneys. With urine, 50-70% is output. From 15 to 30% is excreted with feces.
Indications
Mixed bacterial infections caused by sensitive Gram-positive and Gram-negative microorganisms, in association with anaerobic microorganisms and / or protozoa:
- infections of the respiratory tract (acute bronchitis, chronic bronchitis in the acute stage, pneumonia, bronchiectatic disease);
- infection of the ENT organs (otitis media, sinusitis, frontal sinitis, sinusitis, mastoiditis, tonsillitis, pharyngitis);
- Infections of the oral cavity (acute ulcerative gingivitis, periodontitis, periostitis);
- infection of the kidneys and urinary tract (cystitis, pyelonephritis);
- infections of the pelvic organs and genital organs (prostatitis, adnexitis, salpingitis, oophoritis, endometritis, tubular abscess, pelvioperitonitis);
- intra-abdominal infections (infections of the gastrointestinal tract, biliary tract, intraperitoneal abscesses);
- infections of the skin and soft tissues (infected ulcers, wounds, burns, abscesses, phlegmon, ulcerative skin lesions with diabetic foot syndrome, pressure ulcers);
- infection of bones and joints (osteomyelitis, septic arthritis);
- postoperative infections.
Forms of release
Tablets coated with 250 mg and 500 mg.
Eye drops 3 mg / ml.
Solution for infusions (injections in ampoules for injection) 2 mg / ml.
Tablets coated with a film coat of the combined preparation Tsiprolet A.
Instructions for use and dosage
Pills
The dose of Ciprolet depends on the severity of the disease, type of infection, body condition, age, body weight and kidney function.
In uncomplicated diseases of the kidneys and urinary tract appoint 250 mg twice a day, and in severe cases - 500 mg 2 times a day.
In diseases of the lower respiratory tract of medium severity - 250 mg 2 times a day, and in more severe cases - 500 mg 2 times a day.
For the treatment of gonorrhea, a single dose of Ziprolet in a dose of 250-500 mg is recommended.
With gynecological diseases, enteritis and colitis with severe course and high fever, prostatitis, osteomyelitis appoint 500 mg twice a day (for treatment of ordinary diarrhea, you canapply in a dose of 250 mg 2 times a day).
Tablets should be taken on an empty stomach, with plenty of fluids.
The duration of treatment depends on the severity of the disease, but treatment should always last at least 2 more days after the disappearance of the symptoms of the disease. Usually the duration of treatment is 7-10 days.
Ampoules
The drug should be administered intravenously drip for 30 minutes (200 mg) and 60 minutes (400 mg). The solution for infusion is compatible with 0.9% sodium chloride solution, Ringer's solution, 5% and 10% Dextrose solution, 10% fructose solution, and also a solution containing 5% dextrose solution with 0.225% or 0.45% sodium chloride solution.
The dose of Ciprolet depends on the severity of the disease, the type of infection, the condition of the body, age, body weight and kidney function in the patient.
Single dose, on average, is 200 mg (in severe infections - 400 mg), the frequency of administration is 2 times a day. The duration of treatment depends on the severity of the disease and is 1-2 weeks, if necessary, more prolonged administration of the drug.
In acute gonorrhea, the drug is administered intravenously once in a dose of 100 mg.
For the prevention of postoperative infections are administered intravenously 30-60 min before surgery ina dose of 200-400 mg.
Side effect
- nausea, vomiting;
- diarrhea;
- stomach ache;
- flatulence;
- anorexia;
- dizziness;
- headache;
- increased fatigue;
- anxiety;
- tremor;
- insomnia;
- nightmarish dreams;
- peripheral paralgesia (anomaly of perception of a feeling of pain);
- sweating;
- increased intracranial pressure;
- anxiety;
- confusion of consciousness;
- depression;
- hallucinations;
- migraine;
- fainting;
- impairment of taste and smell;
- impaired vision (diplopia, change in color perception);
- noise in ears;
- hearing loss;
- tachycardia;
- heart rhythm disturbances;
- a decrease in blood pressure;
- leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia;
- hematuria (blood in the urine);
- glomerulonephritis;
- retention of urine;
- itching;
- hives;
- point hemorrhages (petechiae);
- dyspnea;
- vasculitis;
- nodal erythema;
- arthralgia;
- arthritis;
- tenosynovitis;
- ruptures of tendons;
- general weakness;
- superinfection (candidiasis, pseudomembranous colitis);
- pain and burning at the injection site.
Contraindications
- pseudomembranous colitis;
- deficiency of glucose-6-phosphate dehydrogenase;
- pregnancy;
- lactation period (breastfeeding);
- children and adolescents under the age of 18 (before the completion of the process of skeleton formation);
- increased sensitivity to ciprofloxacin or other drugs from the group of fluoroquinolones.
Application in pregnancy and lactation
The drug is contraindicated for use in pregnancy and lactation.
special instructions
If a severe and prolonged diarrhea occurs during or after treatment, the diagnosis of pseudomembranous colitis should be ruled out, which requires immediate discontinuation of the drug and the appointment of appropriate treatment.
If pain occurs in the tendons or when the first signs of tendovaginitis appear, treatment should be discontinued.
During treatment with Ciprolet it is necessary to provide a sufficient amount of fluid while observing normal diuresis.
During treatment with Ciprolet, contact with direct sunlight should be avoided.
Impact on the ability to drive vehicles and manage mechanisms
Patients taking Ciprolet should be careful when driving a car and practicing other potentially hazardous activities,requiring increased attention and speed of psychomotor reactions (especially with simultaneous use of alcohol).
Drug Interactions
Due to the decrease in the activity of microsomal oxidation in hepatocytes, it increases the concentration and prolongs T1 / 2 theophylline (and other xanthines, for example, caffeine), oral hypoglycemic drugs, indirect anticoagulants, and helps to reduce the prothrombin index.
Non-steroidal anti-inflammatory drugs (excluding acetylsalicylic acid) increase the risk of seizures.
Metoclopramide accelerates the absorption of ciprofloxacin, which leads to a decrease in the time to reach its Cmax.
Joint appointment of uricosuric drugs leads to a delay in excretion (up to 50%) and an increase in the plasma concentration of ciprofloxacin.
When combined with other antimicrobial agents (beta-lactams, aminoglycosides, clindamycin, metronidazole), synergy is usually observed; can be successfully used in combination with azlocillin and ceftazidime in infections caused by Pseudomonas spp .; with mezlocillin, azlocillin and other beta-lactamantibiotics - with streptococcal infections; with isoxazolylpenicillins and Vancomycin - with staphylococcal infections; with Metronidazole and Clindamycin - with anaerobic infections.
Increases the nephrotoxic effect of cyclosporine, there is an increase in serum creatinine, so these patients need to monitor this indicator 2 times a week.
With simultaneous reception increases the effect of indirect anticoagulants.
The infusion solution is pharmaceutically incompatible with all infusion solutions and preparations that are physico-chemically unstable under acidic conditions (the pH of the infusion solution of ciprofloxacin is 3.5-4.6). Do not mix the IV solution with solutions having a pH of more than 7.
Analogues of the drug Tsiprolet
Structural analogs for the active substance:
- Altsipro;
- Afenoxin;
- Basijen;
- Betaciprol;
- Vero-Ciprofloxacin;
- Zindolin 250;
- Isfipro;
- Quintor;
- Quipro;
- Liprokhin;
- Microfleks;
- Oftotsipro;
- PROCIPRO;
- Recipro;
- Siflox;
- Ceprova;
- Ciloxane;
- Cipraz;
- Ciprinol;
- Cyprinol SR;
- Ciprobay;
- Ciprobide;
- Ciprobrin;
- Citrodox;
- Ciprolake;
- Ciprolone;
- Cipromed;
- Cipropane;
- Ciprosan;
- Ciprosine;
- Ciprosol;
- Ciprofloxabol;
- Ciprofloxacin;
- Ciprofloxacin Buffus;
- Ciprofloxacin-ACOS;
- Ciprofloxacin-promed;
- Ciprofloxacin-Teva;
- Ciprofloxacin-FPO;
- Ciprofloxacin hydrochloride;
- Cytar;
- Cifloxinal;
- Tsifran;
- The figure of OD;
- Ecocylol.
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