Hikontsil - instructions for use, analogs, reviews and release forms (capsules or tablets 250 mg and 500 mg, powder for oral suspension) antibiotic for the treatment of infections in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Hiconcile. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Hiconcil in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Hiconcile in the presence of existing structural analogues.Use for the treatment of angina, pneumonia, gonorrhea, cystitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Hiconcile - an antibiotic of a group of semisynthetic penicillins of a wide spectrum of action. It is a 4-hydroxyl analogue of ampicillin. Has a bactericidal effect. Amoxicillin (the active substance of the drug Hiconcil) is active against aerobic Gram-positive bacteria: Staphylococcus spp. (staphylococcus) (with the exception of strains producing penicillinase), Streptococcus spp. (streptococcus); aerobic Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli (E. coli), Shigella spp. (Shigella), Salmonella spp. (salmonella), Klebsiella spp. (Klebsiella).

Amoxicillin is resistant to microorganisms that produce penicillinase.

In combination with metronidazole, it shows activity against Helicobacter pylori (Helicobacter pylori). It is believed that Hiconcyl inhibits the development of Helicobacter pylori resistance to metronidazole.

Between amoxicillin and ampicillin there is cross-resistance.

The spectrum of antibacterial action expands with simultaneous use of amoxicillin and clavulanic acid beta-lactamase inhibitor.In this combination, amoxicillin activity increases with respect to Bacteroides spp., Legionella spp. (Legionella), Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other Gram-negative bacteria remain resistant.

Composition

Amoxicillin + excipients.

Pharmacokinetics

When administered orally, amoxicillin is rapidly and completely absorbed from the gastrointestinal tract (GIT), does not degrade in the acidic environment of the stomach. With intravenous, intramuscular administration and ingestion, similar concentrations of amoxicillin are achieved in the blood. The binding of amoxicillin with plasma proteins is about 20%. Chiconcil widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver are reported. About 60% of the dose taken orally is excreted unchanged in the urine by glomerular filtration and tubular secretion. Some amount of amoxicillin is determined in the feces.

Indications

• acute and chronic bronchitis;
• pneumonia (pneumonia);
• acute tonsillitis (sore throat);
• chronic tonsillitis;
• acute and chronic pyelonephritis;
• infectious diseases of the skin and soft tissues, including abscess, furuncle, carbuncle, phlegmon, pyoderma (purulent skin lesion),impetigo (skin infectious disease caused by streptococci and staphylococci);
• gonococcal infection (gonorrhea);
• inflammatory disease of the cervix, including cervicitis (inflammation of the cervix), endocervicitis (inflammation of the mucous membrane of the cervical canal), exocervicitis (infectious inflammation of the outer surface of the cervix);
• inflammatory disease of the uterus, including endometritis (inflammation of the mucous membrane of the uterus), myometritis (inflammatory disease of the uterus flowing with damage to its muscular membrane), metritis (damage to the entire wall of the uterus), pyometra (congestion and retention in the uterine cavity of purulent exudate), abscess the uterus;
• salpingitis (inflammation of the fallopian tubes) and oophoritis (inflammation of the ovaries);
• cystitis (inflammation of the bladder);
• urethritis (inflammation of the urethra);
• chronic gastritis in the phase of exacerbation, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori (in combination with metronidazole);
• leptospirosis;
• listeriosis;
• Lyme disease (tick-borne borreliosis).

Forms of release

Capsules 250 mg and 500 mg (sometimes mistakenly called pills).

Powder for the preparation of a suspension for ingestion of 125 mg and 250 mg in 5 ml.

Instructions for use and dosing regimen

The dosage regimen of Hiconcil is individual.

For oral administration, a single dose for adults and children older than 10 years (with a body weight of more than 40 kg) is 250-500 mg, with a severe course of the disease - up to 1 g.

For children aged 5-10 years, a single dose is 250 mg; at the age from 2 to 5 years - 125 mg; for children under 2 years of age, the daily dose is 20 mg per 1 kg of body weight.

For adults and children, the interval between meals is 8 hours.

In the treatment of acute uncomplicated gonorrhea - 3 g once (in combination with probenecid).

In patients with impaired renal function with creatinine clearance (CK) of 10-40 ml per minute, the interval between doses should be increased to 12 hours; with QC less than 10 ml per minute, the interval between doses should be 24 hours.

Side effect

• allergic reactions: urticaria, erythema, Quincke's edema, rhinitis, conjunctivitis, rarely anaphylactic shock;
• fever;
• pain in the joints;
• eosinophilia;
• possible development of superinfections (especially in patients with chronic diseases or reduced resistance of the body);
• with prolonged use in high doses: dizziness, ataxia, confusion, depression, peripheral neuropathies, convulsions;
• when used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis, rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, hematopoietic disorders (hematopoiesis);
• when used in combination with clavulanic acid: cholestatic jaundice, hepatitis, rarely - erythema multiforme, toxic epidermal necrolysis (Lyell's syndrome), exfoliative dermatitis.

Contraindications

• Infectious mononucleosis;
• lymphocytic leukemia;
• severe GI infections accompanied by diarrhea or vomiting;
• respiratory viral infections;
• allergic diathesis;
• bronchial asthma;
• hay fever;
• increased sensitivity to penicillins and / or cephalosporins;
• for use in combination with metronidazole: diseases of the nervous system; hematopoietic disorders, lymphocytic leukemia, infectious mononucleosis, hypersensitivity to nitroimidazole derivatives;
• for use in combination with clavulanic acid: history of liver function abnormalities and jaundice associated with amoxicillin in combination with clavulanic acid.

Application in pregnancy and lactation

Hiconcil penetrates the placental barrier, in small quantities is excreted in breast milk.

If you need to use amoxicillin during pregnancy, you should carefully weigh the expected benefit of therapy for the mother and the potential risk to the fetus.

With caution apply Hiconcil during lactation (breastfeeding).

Use in children

The use of hiconcil in children is possible according to the dosing regimen.

Amoxicillin in combination with Metronidazole is not recommended for use in patients younger than 18 years.

special instructions

With caution apply Hiconcil in patients prone to allergic reactions.

Patients with a renal dysfunction dose and the interval between Hiconcil doses should be adjusted in accordance with the values ​​of CC.

Amoxicillin in combination with metronidazole should not be used for liver disease.

Against the background of combined therapy with metronidazole, it is not recommended to drink alcohol.

Drug Interactions

Hiconcil can reduce the effectiveness of oral contraceptives.

With the simultaneous use of amoxicillin with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin), synergy appears; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

Amoxicillin strengthens the effect of indirect anticoagulants, suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index.

Amoxicillin reduces the effect of drugs, in the process of metabolism of which parahaminobenzoic acid (PABA) is formed.

Probenecid, diuretics, allopurinol, phenylbutazone, non-steroidal anti-inflammatory drugs (NSAIDs) reduce the tubular secretion of Hiconcil, which may be accompanied by an increase in its concentration in the blood plasma.

Antacids, glucosamine, laxatives, aminoglycosides slow down and decrease, and Ascorbic acid increases the absorption of amoxicillin.

With combined use of Hiconcil and clavulanic acid, the pharmacokinetics of both components do not change.

Analogs of the drug Hiconcil

Structural analogs for the active substance:

• Amoxisar;
• Amoxicillin;
• Amosin;
• Gonoform;
• Grunamox;
• Danemox;
• Ospamox;
• Flemoxin Solutab;
• EcoBall.

Analogues of the drug Hiconcil on the pharmacological group (penicillins);

• Amovicomb;
• Amoxivan;
• Amoxiclav;
• Amoxisar;
• Amoxicillin;
• Amoxicillin + Clavulanic acid;
• Amosin;
• Ampioks;
• Ammisid;
• Ampicillin;
• Arlette;
• Augmentin;
• Bactocklave;
• Benzylpenicillin;
• Betaclav;
• Bicillin;
• Vepicombin;
• Verklav;
• Gonoform;
• Grunamox;
• Danemox;
• Zetsil;
• Carbenicillin;
• Clamosar;
• Cliacil;
• Cloxacillin;
• Libacil;
• Maripen;
• Médoclase;
• Novaklav;
• Oxamp;
• Oksamsar;
• Oxacillin;
• Ospamox;
• Ospen;
• Panklav;
• Penicillin;
• Penodyl;
• Pensilina;
• Pentrexyl;
• Piperacillin sodium + Tazobactam sodium;
• Piprax;
• Pipracil;
• Picillin;
• Prostaflin;
• Puricillin;
• Ranklav;
• Rapiklav;
• Retarpen;
• Stadacillin;
• Sultasin;
• Tazocine;
• Taromentine;
• Tacillin;
• Timentin;
• Trifamox;
• Unazine;
• Phenoxymethylpenicillin;
• Fibell;
• Flemoclav Solutab;
• Flemoxin Solutab;
• Flukloxacillin;
• Foraklav;
• Helicocin;
• Helithrix;
• Ecobol;
• Ecoclave;
• Extensillin.

Response of a therapist

Ampicillin in the treatment of infectious diseases is our everything. Therefore, the drug Hiconcil I often appoint patients with bronchitis, pneumonia, sore throats, inflammatory processes in the urinary tract. An excellent result Hiconcil also shows in the treatment of exacerbations of chronic diseases, namely chronic tonsillitis, bronchitis, pyelonephritis. As for side effects, they, of course, happen, but it is rare. Undesirable reactions are most often caused by skin rashes, which quickly disappear after the drug is withdrawn. It is encouraging that many pathogenic microorganisms have not yet been able to develop resistance to ampicillin and remain sensitive to it.

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