Demoton B - instructions for use, analogs, reviews and release forms (injections in ampoules for injections of 2 ml) of the drug for the treatment of vitamin B deficiency, radiculitis, neuralgia and ischemic heart disease in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Demeton B. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Demoton B in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Demoton B in the presence of existing structural analogs. Use to treat deficiency of B vitamins, radiculitis, neuralgia and ischemic heart disease in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Demeton B - a complex of vitamins. The drug regulates protein, carbohydrate and fat metabolism, it is necessary for the normal functioning of the central nervous system, thyroid, liver, gastrointestinal tract, skin and mucous membranes, replenishes the deficiency of B vitamins.

Vitamin B1 (thiamine hydrochloride) in the human body as a result of phosphorylation processes is converted into cocarboxylase, which is a coenzyme of many enzyme reactions. Vitamin B1 plays an important role in carbohydrate, protein and fat metabolism, as well as actively participates in the processes of nervous excitation in synapses, improves the metabolism of myocardiocytes and their contractile function.

Vitamin B2 (riboflavin) is the most important catalyst in the processes of cellular respiration and visual perception. Riboflavin, regulating the oxidation-reduction processes, takes part in carbohydrate, protein and fat metabolism. Riboflavin plays an important role in the formation of deoxyribonucleic acid, participates in the synthesis of hemoglobin, promotes tissue regeneration processes (including skin cells),correction of trophic disorders in intestinal cells and normalization of the activity of the stomach and intestines.

Vitamin B6 (pyridoxine) plays an important role in the metabolism. Vitamin B6 is necessary for the normal functioning of the central and peripheral nervous system. Participates in the biosynthesis of neurotransmitters: dopamine, norepinephrine, adrenaline, histamine and gamma-aminobutyric acid (GABA).

Vitamin B6 promotes normalization of lipid metabolism.

Nicotinamide (vitamin PP) in the form of nicotinamide adenine nucleotide (NAD) and its phosphate (NADP) are part of many enzymes involved in the metabolism of proteins necessary for cellular respiration, glycolysis and fat synthesis.

Composition

Thiamine hydrochloride 10 mg + Pyridoxine hydrochloride 4 mg + Riboflavin sodium phosphate is equivalent to riboflavin 4 mg + Nicotinamide 40 mg + excipients.

Pharmacokinetics

Thiamine hydrochloride is metabolized in the liver, metabolites are excreted in the urine. It penetrates the blood-brain barrier, placental barriers, found in breast milk. In case of an overdose, it is excreted in the urine and then unchanged.

Pyridoxine hydrochloride after intramuscular injection is rapidly absorbed into the bloodstream and distributed in the body. About 80% of the vitamin binds to blood plasma proteins. Pyridoxine is distributed throughout the body, passes through the placenta and is found in breast milk, is deposited in the liver. It is excreted in the urine.

Riboflavin is excreted in the urine in the form of metabolites. When the dose is increased, most of the drug is excreted in the urine, unchanged.

Nicotinamide is quickly distributed to all tissues of the body. A small amount of it is excreted in the urine unchanged.

Indications

hypo- and avitaminosis B1, B2, B6, including in patients on enteral feeding through the probe, on hemodialysis;
malabsorption syndrome (intestinal absorption disorders);
polyneuropathy of various etiologies, including diabetic and alcoholic;
viral hepatitis;
encephalopathy (diabetic, alcoholic and others);
neuritis;
Neuralgia, including the trigeminal nerve, intercostal;
radiculitis, lumbago;
plexitis, peripheral paresis and paralysis;
paresis of the facial nerve;
myalgia (pain in the muscles);
intestinal atony;
severe liver dysfunction;
myocardial dystrophy;
ischemic heart disease (IHD);
rheumatic heart disease;
chronic circulatory failure;
thyrotoxicosis;
chronic alcoholism;
shingles;
dermatosis, neurodermatitis;
long-term non-healing wounds and ulcers;
asthenic syndrome;
radiation sickness;
menorrhagia (uterine bleeding);
anemia;
when using isoniazid anti-tuberculosis drugs;
prevention of stomatitis, glossitis, gastritis, enteritis, colitis, proctitis after prolonged use of antibiotics;
in ophthalmology (gemeralopia, conjunctivitis, keratitis, iritis, cataract, corneal ulcer);
hypovitaminosis during pregnancy and lactation (breastfeeding).

Forms of release

Solution for injection 2 ml (injections in ampoules).

Instructions for use and dosing regimen

Demoton B is administered intramuscularly or slowly intravenously.

The daily dose to be administered depends on the age of the patient: for children from 3 to 6 years - 1 ml of the drug, from 6 to 12 years - 2 ml (one ampoule) of the drug, from 12 years and older - 2-4 ml of the drug.

The length of the course of treatment depends on the assessment of the patient's clinical status. The recommended course of treatment is 10 to 20 days.If necessary, it can be extended on the recommendation of the attending physician, but no more than up to 30 days.

Side effect

allergic reactions;
itching;
tachycardia (heart palpitations);
anaphylactic shock;
paresthesia (spontaneous sensations of burning, tingling, crawling);
deterioration of touch;
drowsiness (with prolonged use of the drug in high doses).

Contraindications

increased sensitivity to vitamins B1, B2, B6, nicotinamide or excipients of the drug;
children under 3 years.

Application in pregnancy and lactation

The conducted studies did not reveal an increased risk for the fetus and the baby when treated with the drug Demoton B during pregnancy and lactation.

Use in children

Contraindicated in childhood up to 3 years.

Application in elderly patients

There are no special cautions regarding the use of the drug Demoton B in the elderly.

special instructions

When treated with Demoton B, it is possible to stain urine yellow, which is not clinically significant and is due to the presence of riboflavin in the formulation.

Impact on the ability to drive vehicles and manage mechanisms

Data on the impact on the ability to drive vehicles or potentially dangerous mechanisms are not available.

Drug Interactions

Thiamin completely dissolves in solutions containing sulfites. Antacids reduce the absorption of vitamin B1. Thiamin is incompatible with mercuric chloride, iodide, carbonate, acetate, tannic acid, iron-ammonium citrate, as well as sodium phenobarbital, benzyl-penicillin, erythromycin, glucose and metabisulphite. Copper accelerates the breakdown of thiamine, and, in addition, thiamine loses its effect when pH values increase (pH more than 3).

Vitamin B6 should not be prescribed to patients taking levodopa, as it weakens the effect of the drug for the treatment of parkinsonism. Vitamin B6 reduces the therapeutic effect of Phenobarbital and phenytoin by 50%.

Nicotinamide enhances the effect of antihypertensive drugs and is an Isoniazid agonist.

Analogues of the drug Demoton B

There are no structural analogs to the active substance of the drug Demeton B.

Analogues of the drug Demoton B on the pharmacological group (vitamins and vitamin-like agents in combinations):

Additive;
Aevit;
Ambien;
Ascorutin;
Ascofol;
Beviplex;
Benfolipen;
Berroca;
Biovital;
Velmen;
Vitabeks;
Vitagamma;
Vitaspectrum;
Vitatcitrol;
Vitrum;
Hexavit;
Gendevit;
Heptavit;
Decamewith;
Jériton;
Jungle;
Doppelherz;
Duovit;
Ideos;
Jodilife;
Calcevit;
Kaltsinov;
Quadevite;
Complivit;
Lavita;
Livolin Forte;
Limanowit E;
Macrovitis;
Maxamin forte;
Materna;
Milgamma;
Multi-tabs;
Natemille;
Neurobion;
Neurogamma;
Neuromultivitis;
Oligovit;
Pantobrigger;
Pentovit;
Perfectil;
Pikovitz;
Pregnavit;
Pregnacea;
The Revalid;
Revit;
Ricavit;
Sana'a-Sol;
Supradin;
Taxophytus;
Taufon;
Teravit;
Trigamma;
Triovit;
Undevit;
Upsovit;
Foliber;
Centrum;
Elevit Pronatal;
Unigamma;
Unicab.

Review of the neurologist's doctor

With neuralgia, radiculitis, neuritis with severe pain syndrome in complex treatment, I prescribe to patients intramuscular injections of the drug Demeton B. As the patients say, the main disadvantage of this medication is unbearable pain when the solution is injected into the muscle. Therefore, I try not to assign courses of Demoton B for more than 10 days. Patients with a history of allergic reactions to multivitamin preparations usually develop similar reactions to Demato B.Therefore, I always collect allergic anamnesis in detail, trying to find out if the patient ever had undesirable reactions to multivitamin funds.

If there are no analogues of the medication for the active substance, you can go to the links below for diseases, from which the corresponding drug helps, and to look at the available analogs for therapeutic effects.

Used for the treatment of diseases: hypovitaminosis, vitamin deficiency, lack of vitamins, avitaminosis, malabsorption syndrome, polyneuropathy, viral hepatitis, encephalopathy, neuritis, neuralgia, radiculitis, plexite, chronic alcoholism, asthenic syndrome, radiation sickness