Gastrosidin - instructions for use, analogs, reviews and release forms (20 mg and 40 mg tablets) drugs for the treatment of stomach and duodenal ulcers, reflux esophagitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Gastrosidine. Comments of visitors of the site - consumers of this medication, as well as opinions of specialists on the use of gastrosidin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analgesics of gastrosidin in the presence of existing structural analogues. The use of gastric ulcers and duodenal ulcers, reflux esophagitis,Zollinger-Ellison syndrome in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Gastrosidine - blocker of histamine H2-receptors of the 3rd generation. Suppresses the production of hydrochloric acid, both basal and stimulated with histamine, gastrin and, to a lesser extent, acetylcholine. Simultaneously with a decrease in the production of hydrochloric acid and an increase in pH, the activity of pepsin decreases. Duration of action for a single dose depends on the dose and is from 12 to 24 hours.

Composition

Famotidine + excipients.

Pharmacokinetics

After ingestion quickly, but not completely, absorbed from the gastrointestinal tract (GIT). The maximum concentration of Famotidine (active ingredient of the drug Gastrosidin) in blood plasma is achieved after 2 hours. Bioavailability of it is 40-45% and slightly changes in the presence of food. Binding to blood proteins is 15-20%. A small portion of the active substance is metabolized in the liver to form famotidine S-oxide. The most part is excreted unchanged in the urine.

Indications

• stomach ulcers, including those complicated by hemorrhage;
• duodenal ulcer, including those complicated by hemorrhage;
• prevention of recurrences of peptic ulcer of the stomach and duodenum;
• gastroesophageal reflux with esophagitis;
• Zollinger-Ellison syndrome and other specified disorders of internal secretion of the pancreas;
• diseases and conditions accompanied by increased secretion of gastric juice;
• prevention of erosive and ulcerative gastrointestinal lesions against the background of non-steroidal anti-inflammatory drugs (NSAIDs).

Forms of release

Tablets coated with 20 mg and 40 mg.

Instructions for use and dosing regimen

Inside, for the treatment of peptic ulcer of the stomach and duodenum - 40 mg at night for 4 weeks (in the absence of effect - up to 8 weeks), for the prevention of exacerbations - 20 mg at night for 6 months, with Zollinger-Ellison syndrome - 20 mg every 6 hours (the maximum daily dose is 400 mg).

Side effect

• lack of appetite;
• dry mouth;
• disorders of taste;
• nausea, vomiting;
• bloating;
• diarrhea or constipation;
• Cholestatic (due to stagnation of bile) jaundice;
• increased levels of transaminases in blood plasma;
• headache;
• increased fatigue;
• noise in ears;
• transient mental disorders;
• arrhythmia (cardiac rhythm disturbance);
• agranulocytosis, pancytopenia, leukopenia, thrombocytopenia;
• muscle pain;
• pain in the joints;
• itching;
• fever;
• alopecia (baldness);
• common acne;
• dry skin.

Contraindications

• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to famotidine.

Application in pregnancy and lactation

Gastrosidine is contraindicated in pregnancy and lactation. Famotidine is excreted in breast milk.

Use in children

The clinical experience of using gastrosidin in children is limited.

special instructions

Gastrosidine is used with caution in patients with impaired renal and hepatic function.

Before starting treatment, it is necessary to exclude the possibility of having a malignant disease of the esophagus, stomach or duodenum.

Does not change the activity of microsomal enzymes of the liver.

It is necessary to observe the interval between taking antacids and famotidine for at least 1-2 hours.

Drug Interactions

With simultaneous use with anticoagulants, the possibility of increasing prothrombin time and development of bleeding is not ruled out.

With the simultaneous use of gastrosidin with antacids, magnesium hydroxide and aluminum hydroxide, a decrease in the absorption of famotidine is possible.

With simultaneous application with itraconazole, it is possible to reduce the concentration of Itraconazole in the blood plasma and reduce its effectiveness.

With simultaneous use with nifedipine, the case of a decrease in the minute volume of the heart and cardiac output is described, apparently due to the enhancement of the negative inotropic effect of nifedipine.

With simultaneous use with norfloxacin, the concentration of Norfloxacin in the blood plasma decreases; with probenecid - the concentration of famotidine in the blood plasma increases.

With simultaneous application, the case of increasing the concentration of phenytoin in plasma with a risk of developing toxic effects has been described.

With simultaneous use, the bioavailability of cefpodoxime decreases, apparently due to a decrease in its solubility in the contents of the stomach when the pH of the gastric juice is increased under the influence of gastrosidin.

With simultaneous application with cyclosporine, a slight increase in the concentration of cyclosporine in the blood plasma is possible.

Analogues of the drug Gastrosidine

Structural analogs for the active substance:

• Hysterogen;
• Kwamatel;
• Pepsidine;
• Ulfamide;
• Famopsin;
• Famosan;
• Famotel;
• Famotidine.

Analogues of the drug Gastrosidin on the pharmacological group (H2-antihistamines):

• Aksid;
• Acidex;
• Acyl;
• Belomet;
• Hysterogen;
• Gertokalm;
• Gistak;
• Histodyl;
• Zantak;
• Zantyn;
• Zoran;
• Kwamatel;
• Pepsidine;
• Pyloride;
• Primamet;
• Raniburl;
• Ranigast;
• Ranisan;
• Ranital;
• Ranitidine;
• Ranitin;
• Rantak;
• Roxane;
• Ranks;
• Simesan;
• Ulkodin;
• Ulkosan;
• Ulfamide;
• Famopsin;
• Famosan;
• Famotel;
• Famotidine;
• Cimetidine.

Recall of a gastroenterologist

I prescribe the drug Gastrosidin to a patient with peptic ulcer of the stomach and duodenum in the remission phase to prevent the development of relapses of the disease. The preventive course lasts six months. And in those cases when patients conscientiously and regularly take pills, they manage to avoid relapses of peptic ulcer. Important conditions are compliance with the diet and the rejection of bad habits. Patients tolerate gastrosidin well. I do not remember that in my practice there were any serious adverse reactions during the patients taking this drug.

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