Famotidine - instructions for use, analogs, reviews and release forms (20 mg and 40 mg tablets) drugs for the treatment of gastritis, ulcers, gastroduodenitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Famotidine. There are reviews of visitors to the site - consumers of this medication, as well as the opinions of specialists in the use of Famotidine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Famotidine in the presence of existing structural analogues. Use for the treatment of gastritis, ulcers, gastroduodenitis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Famotidine - blocker of H2-histamine receptors of the 3rd generation. Suppresses basal and hydrochloric acid products stimulated by histamine, gastrin and acetylcholine. Reduces the activity of pepsin. Strengthens the protective mechanisms of the gastric mucosa and promotes the healing of damage associated with the action of hydrochloric acid (including the cessation of gastrointestinal bleeding and cicatrization of stress ulcers) by increasing the formation of gastric mucus, the content of glycoproteins in it, stimulating the secretion of bicarbonate by the gastric mucosa, endogenous synthesis of prostaglandins in it and the rate of regeneration.

Essentially does not change the concentration of gastrin in the plasma.

After oral administration, the effect begins after 1 hour, reaches a maximum within 3 hours. The duration of the drug in a single dose depends on the dose and is from 12 to 24 hours.

Composition

Famotidine + excipients.

Pharmacokinetics

After oral administration, it is rapidly absorbed from the digestive tract. Binding to plasma proteins is 15-20%. It penetrates through the placental barrier and is excreted in breast milk. 30-35% of famotidine is metabolized in the liver (with the formation of S-oxide).Elimination, mainly, occurs through the kidneys: 27-40% of the drug is excreted in the urine unchanged.

Indications

• peptic ulcer of the stomach and duodenum, prevention of relapses;
• erosive gastroduodenitis;
• functional dyspepsia associated with an increased secretory function;
• symptomatic and stressful gastrointestinal ulcers;
• reflux esophagitis;
• prevention of relapses associated with prolonged intake of NSAIDs;
• Zollinger-Ellison syndrome;
• systemic mastocytosis;
• polyendocrine adenomatosis;
• prevention of bleeding recurrences in the postoperative period;
• prevention of aspiration of gastric juice in patients undergoing general anesthetic surgery (Mendelssohn syndrome);
• prevention of aspiration pneumonitis;
• dyspepsia with epigastric or chest pain, arising at night or associated with food intake.

Forms of release

Tablets coated with 20 mg and 40 mg.

Instructions for use and dosing regimen

Inside, not liquid, squeezed enough water.

Adults

With peptic ulcer of stomach and duodenum in the phase of exacerbation, symptomatic ulcers,erosive gastroduodenitis usually prescribed 20 mg twice a day or 40 mg once a day at night. If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks.

With dyspepsia associated with increased secretory function of the stomach, appoint 20 mg 1-2 times a day.

In order to prevent recurrences of peptic ulcer, 20 mg once a day before bedtime is prescribed.

When refpux-esophagitis - 20-40 mg 2 times a day for 6-12 weeks.

With Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 20 mg every 6 hours and can be increased to 160 mg every 6 hours.

To prevent the aspiration of gastric juice with general anesthesia appoint 40 mg in the evening and / or in the morning before the operation.

Famotidine tablets should be swallowed without chewing, with plenty of water.

In renal failure, if the CK is less than 30 ml / min or the serum creatinine content is more than 3 mg / 100 ml, the daily dose of the drug should be reduced to 20 mg.

Children over 3 years old

With peptic ulcer of the stomach and duodenum in the phase of exacerbation,reflux-esophagitis Famotidine is prescribed for children weighing more than 10 kg at a rate of 2 mg / kg per day, divided into 2 doses or 20 mg twice a day, but not more than 40 mg per day.

Side effect

• dry mouth;
• nausea, vomiting;
• abdominal pain;
• flatulence;
• constipation;
• diarrhea;
• a violation of appetite;
• acute pancreatitis;
• headache;
• dizziness;
• insomnia;
• anxiety;
• noise in ears;
• increased fatigue;
• drowsiness;
• depression;
• nervousness;
• psychosis;
• blurred vision;
• paresis of accommodation;
• confusion of consciousness;
• hallucinations;
• hyperthermia;
• bradycardia;
• arrhythmia;
• vasculitis;
• a decrease in blood pressure;
• AV blockade;
• dry skin;
• alopecia;
• common acne;
• skin rash;
• itching;
• bronchospasm;
• angioedema;
• anaphylactic shock;
• leukopenia, thrombocytopenia, agranulocytosis, pancytopenia;
• hyperprolactinemia;
• gynecomastia;
• amenorrhea;
• decreased libido;
• impotence;
• fever;
• muscle pain;
• pain in the joints.

Contraindications

• pregnancy;
• lactation period;
• children under 3 years of age with a body weight of less than 20 kg (for this dosage form);
• increased sensitivity to famotidine and other blockers of histamine H2 receptors.

Application in pregnancy and lactation

During pregnancy and lactation, the use of the drug is contraindicated.

Use in children

Children over 3 years:

With peptic ulcer of the stomach and duodenum in the phase of exacerbation, reflux-esophagitis Famotidine is prescribed for children with a body weight of more than 10 kg at a rate of 2 mg / kg per day, divided into 2 doses or 20 mg twice a day, but not more than 40 mg per day.

Contraindicated in children under 3 years of age with a body weight of less than 20 kg (for this dosage form).

special instructions

Before the beginning of treatment it is necessary to exclude the possibility of having a malignant disease of the esophagus, stomach or duodenum, since Famotidine can mask symptoms.

Symptoms of duodenal ulcer can disappear within 1-2 weeks, therapy should continue until scarring is confirmed by endoscopic or X-ray data.

They abolish famotidine gradually because of the risk of developing the "rebound" syndrome with a sharp cancellation.

With long-term treatment in weakened patients, as well as under stress, bacterial lesions of the stomach are possible with the subsequent spread of infection.

Famotidine (a blocker of histamine H2 receptors) should be taken 2 hours after taking Itraconazole or Ketoconazole in order to avoid a significant decrease in their absorption.

It counteracts the influence of pentagastrin and histamine on the acid-forming function of the stomach, therefore it is not recommended to apply famotidine for 24 hours prior to the test.

Famotidine suppresses skin reaction to histamine, thus leading to false negative results (it is recommended to stop using Famotidine before conducting diagnostic skin tests to detect an allergic skin reaction of immediate type).

During treatment, avoid eating foods, beverages and other medications that can cause irritation of the gastric mucosa.

The efficacy of famotidine in inhibiting night secretion of acid in the stomach can be reduced by smoking.

Patients with burns may need to increase the dose of the drug due to increased clearance.

If a dose is missed, it must be taken as soon as possible; Do not take if it is time to take the next dose; do not double the dose. If there is no improvement, consult a doctor.

Drug Interactions

Increases the absorption of Amoxicillin and clavulanic acid.

Compatible with 0.18 and 0.9% sodium chloride solution, 4% and 5% Dextrose solution, 4.2% sodium bicarbonate solution.

With simultaneous use with antacid agents containing magnesium and aluminum, sucralfate decreases the intensity of absorption of famotidine, therefore, a break between taking these drugs should be at least 1-2 hours.

Due to the increase in the pH of the contents of the stomach with simultaneous intake may decrease absorption of ketoconazole and itraconazole.

Drugs that depress the bone marrow increase the risk of developing neutropenia.

Inhibits the metabolism in the liver of diazepam, hexobarbital, propranolol, lidocaine, phenytoin, theophylline, indirect anticoagulants.

Analogues of the drug Famotidine

Structural analogs for the active substance:

• Hysterogen;
• Gastrosidin;
• Kwamatel;
• Kwamatel mini;
• Pepsidine;
• Ulfamide;
• Famopsin;
• Famosan;
• Famotel;
• Famotidine of Stade;
• Famotidine Akos;
• Famotidine Acry;
• Famotidine Apo.

Analogues for the pharmacological group (agents for the treatment of gastric ulcers):

• Acrylase;
• Almagel;
• Almol;
• Alfogel;
• Alugastrin;
• Anacid forte;
• Antioxidant;
• Acidex;
• Acyl;
• Belomet;
• Betamax;
• Bimaral;
• Venter;
• Galavit;
• Galidor;
• Gastal;
• Gasterin;
• Gastricid;
• De Nol;
• Derinat;
• Dibazol;
• Drotaverine;
• Zantak;
• A zerocide;
• Zolser;
• Iberogast;
• Controllers;
• Lanzap;
• Lansoprazole;
• Losek;
• Maalox;
• Metoclopramide;
• Milk of magnesia;
• Nexium;
• But the spine;
• But the forte;
• Nolpaz;
• Omez;
• Omeprazole;
• Omeface;
• Panavir;
• Ranigast;
• Ranitidine;
• Roxane;
• Rutatsid;
• Spazmol;
• Spasmonet;
• Sulpiride;
• Talcid;
• Ulkodin;
• Ultop;
• Phosphalugel;
• Cisagast;
• Cigapan;
• Eglek;
• Erbisol.

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