Rellip - instructions for use, analogs, reviews and release forms (15 mg sleeping pills) drugs for the treatment of sleep disorders and insomnia in adults, children and pregnancy. Composition and habituation

In this article, you can read the instructions for using the drug Leslie. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Raslip in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Raslip if there are existing structural analogues. Use to treat sleep disorders and insomnia in adults, children, as well as during pregnancy and lactation.Composition and the possibility of developing addiction when taking the drug.

Leslie - blocker of histamine H1 receptors from the group of ethanolamines. It has hypnotic, antihistamine, sedative and m-holinoblocking action.

Reduces the time of falling asleep, increases the duration and quality of sleep, does not change the phase of sleep.

The duration of the action is 6-8 hours.

Composition

Doxylamine succinate + excipients.

Pharmacokinetics

After ingestion, it is rapidly and almost completely absorbed from the digestive tract. Cmax in blood plasma is determined on average 2 hours after ingestion. Well penetrates through the histohematological barriers, the blood-brain barrier (BBB). Metabolised in the liver. 60% is excreted by the kidneys unchanged, in part - through the intestine.

In patients older than 65 years, as well as with hepatic and renal failure, the half-life may be prolonged. When you repeat the course of treatment Css drug and its metabolites in blood plasma is reached later and at a higher level.

Indications

• transient sleep disturbances (insomnia).

Forms of release

The tablets covered with a cover of 15 mg.

Instructions for use and dosage

The drug is used inside, 15-30 minutes before bedtime. The tablets are washed down with a small amount of liquid.

The recommended dose is 1 / 2-1 tablets per day. If the treatment is ineffective, the dose can be increased to 2 tablets on the recommendation of the doctor.

Duration of treatment - from 2 to 5 days; If insomnia persists, the patient should consult a doctor. Strong addiction with the use of Rheslip does not develop.

In connection with the data on the increase in plasma concentration and the decrease in plasma clearance of doxylamine, patients with renal and hepatic insufficiency are recommended to reduce the dose.

Histamine H1 receptor blockers should be given with caution to patients over 65 years of age due to possible dizziness and delayed reactions with a risk of falls (eg, at night awakenings after taking sleeping pills). In view of data on the increase in plasma concentration, decrease in plasma clearance and an increase in the half-life of doxylamine, a dose reduction is recommended.

Side effect

• constipation;
• dry mouth;
• a feeling of palpitations;
• visual impairment and accommodation;
• blurred vision;
• drowsiness during the day (in this case, the dose should be reduced);
• confusion of consciousness;
• hallucinations;
• retention of urine;
• increased level of CK;
• rhabdomyolysis.

If any of the undesirable reactions specified in the instruction are aggravated or any other undesirable phenomena not indicated in the instructions are noted, the patient should be informed about this to the doctor.

Contraindications

• closed angle glaucoma or family history of angle-closure glaucoma;
• diseases of the urethra and prostate gland, accompanied by a violation of the outflow of urine;
• lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
• children and adolescence up to 15 years;
• hypersensitivity to doxylamine, other components of the drug or to other antihistamines.

Carefully:

• patients with cases of apnea in history (due to the fact that doxylamine can aggravate the syndrome of nocturnal sleep apnea);
• patients over 65 years of age (due to possible dizziness and delayed reactions with the risk of falls (for example, during night awakenings after taking sleeping pills), and also in connection with the possible increase in the half-life period);
• patients with renal and hepatic insufficiency (the half-life may increase).

Application in pregnancy and lactation

Based on the results of adequate and well-controlled studies, doxylamine can be used in pregnant women throughout pregnancy.

The use of the drug Rellip during breastfeeding is contraindicated. If you need to use the drug during lactation, breastfeeding should be discontinued.

Use in children

Contraindicated use of the drug in children and adolescents under 15 years.

Application in elderly patients

The drug should be administered with caution to patients older than 65 years.

special instructions

It should be taken into account that insomnia can be caused by a number of reasons, in which there is no need to prescribe this medication.

The preparation of Rellip has a sedative effect, suppresses cognitive abilities and slows down the psychomotor reactions. The first generation of histamine H1 receptor blockers can cause m-holinoblock, antiall-adrenergic and antiserotonin effects, which can cause dry mouth, constipation, urinary retention, accommodation and vision disorders.

Like all sedatives or hypnotics, doxylamine may worsen sleep apnea syndrome by increasing the number and duration of episodes of apnea.

One tablet contains 50 mg of lactose monohydrate that should be considered in patients with a rare congenital galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption.

Impact on the ability to drive vehicles and manage mechanisms

In connection with possible drowsiness during the day to avoid car driving, using machinery, and other activities that require high concentration and psychomotor speed reactions.

Overdose

Symptoms: daytime sleepiness, agitation, mydriasis, accommodation disturbances, dry mouth, flushing of the face and neck, pyrexia, sinus tachycardia, delirium, hallucinations, depressed mood, anxiety, incoordination, tremors, athetosis, convulsions (epileptic syndrome) , a coma.

Involuntary movements are sometimes harbingers of convulsions, which may indicate a severe degree of poisoning.Even in the absence of convulsions severe poisoning with doxylamine can cause the development of rhabdomyolysis, which is often accompanied by acute renal failure. In such cases, standard therapy with constant control of the level of CK is indicated.

If symptoms of poisoning occur, the patient should consult a doctor immediately.

Treatment: symptomatic (m-cholinomimetics and other agents), as a first aid is shown the reception of activated charcoal (50 g for adults and 1 g / kg of body weight for children).

Drug Interactions

With the simultaneous use of the drug Rellip with sedative antidepressants (amitriptyline, doxepin, mianserin, mirtazapine, trimipramine), barbiturates, benzodiazepines, clonidine, morphine derivatives (analgesics, antitussives), neuroleptics, anxiolytics, blockers of histamine H1 receptors with sedative effect, antihypertensive drugs central action, thalidomide, baclofen, pizotifenum, the inhibitory effect on the central nervous system is enhanced.

When used simultaneously with m-holinoblokiruyuschimi means (atropine, imipramine antidepressants, antiparkinsonian drugs, atropine antispasmodics,disopyramide, phenothiazine neuroleptics), the risk of such side effects as urinary retention, constipation, and dry mouth increases.

Because ethanol (alcohol) enhances the sedative effect of most antagonists of histamine H1 receptors, including. of the preparation, it is necessary to avoid simultaneous use of this drug with alcoholic beverages and drugs containing ethanol.

Analogs of the medicine

Structural analogs for the active substance:

• Valocordin Doxylamine;
• Doxylamine succinate;
• Donormil.

Analogues on the curative effect (funds for the treatment of insomnia):

• Aminazine;
• Andante;
• Barbovan;
• Berlidorm 5;
• Bilobil;
• Bromazepam;
• Bromide;
• Valdisphere;
• Valerian;
• Valocordin;
• Valoserdine;
• Wernison;
• Glycine;
• Diazepam;
• Donormil;
• Dormikum;
• Dormiplant;
• Zopiclone;
• Iwadal;
• Imovan;
• Insomnia;
• Klozasten;
• Corwaldine;
• Corvalol;
• Corvalol Forte;
• Xanax;
• Xanax retard;
• Lexotan;
• Loram;
• Laurafen;
• Melaxen;
• Melarena;
• Merlit;
• Mirtazonal;
• Mystic;
• Morpheus;
• Napoton;
• Neurobutal;
• The Nervochel;
• Nitrazepam;
• Nitram;
• Noblessite;
• NovoPassit;
• Nozepam;
• Oxazepam;
• Passidorm;
• Persen;
• Piklodorm;
• Radedorm 5;
• Radepour 10;
• Relaxon;
• Relium;
• Rudotel;
• Sanason Lek;
• Sanvall;
• Seduxen;
• Somnol;
• Tazepam;
• Terialgen;
• Tizerzin;
• A sedative (sedative) collection;
• Phenazepam;
• Fenibut;
• Phenobarbital;
• Chloroproticsen;
• Circadian;
• Elenium;
• Elzepam;
• Eunotin;
• Yantavit.

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