Maxigan - instructions for use, analogs, testimonials and release forms (tablets, injections in ampoules for injection) for the treatment of headache and toothache, joints for arthrosis, arthritis in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Maxigan. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Maxigan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Maxigan in the presence of existing structural analogues.Use for the treatment of headaches and dental pain, joints with arthrosis, arthritis in adults, children, as well as during pregnancy and lactation. Composition and interaction of anesthetic drug with alcohol.

Maxigan - combined preparation with analgesic and antispasmodic effect.

The composition of the drug includes: non-narcotic analgesic methamizole sodium (analgin), myotropic antispasmodic drug pituophenone hydrochloride and m-holinoblokiruyuschee fenpiverinia bromide.

Metamizole sodium - an analgesic-antipyretic, is a derivative of pyrazolone. Has analgesic, antipyretic and anti-inflammatory effect.

Pitofenone hydrochloride has a direct myotropic effect on the smooth muscles of the internal organs and causes it to relax.

Fentiverinia bromide due to m-holinoblokiruyuschego action has an additional relaxing effect on smooth muscles.

The combination of the three components of the drug leads to a mutual enhancement of their pharmacological action, expressed in relieving pain, relaxing smooth muscles and reducing the elevated temperature.

Composition

Metamizole sodium + Pitophenone hydrochloride + Fentpuverinium bromide + excipients.

Indications

• moderately pronounced pain syndrome with spasms of smooth muscles of internal organs (including renal colic, hepatic colic, biliary colic, intestinal colic, algodismenorea (painful periods), dyskinesia of bile ducts);
• for short-term symptomatic treatment in neuralgia, arthralgia, ischialgia, myalgia;
• as an auxiliary preparation for pain relief after surgical interventions and diagnostic procedures;
• to reduce elevated body temperature for colds and infectious-inflammatory diseases (for tablets).

Forms of release

Tablets 500 mg + 5 mg + 100 μg.

Solution for injections (injections in ampoules).

Instructions for use and dosage

Maxigan in the form of tablets for oral administration is prescribed for adults and adolescents over 15 years 1-2 tablets 2-3 times a day. The maximum daily dose is 6 tablets. Duration of reception - no more than 5 days.

Children aged 6-8 years are prescribed 1/2 tablet, children aged 9-12 years - 3/4 tablets, children aged 13-15 years - 1 tablet.Multiplicity of reception - 2-3 times a day.

Tablets are preferable to take after meals.

Maxigan in the form of a solution for injection is prescribed intramuscularly or intravenously. Adults and adolescents over 15 years of age with severe acute colic are injected iv slowly (1 ml for 1 minute) 2 ml each. If necessary, the drug is administered again after 6-8 hours.

In / m the drug is administered 2 ml 2 times a day. The maximum daily dose is 4 ml. Duration of treatment - no more than 5 days.

For children, the drug is given in / m or / in depending on the age and body weight.

If necessary, repeated administration of the drug in the same doses is possible.

Before the introduction of the solution, it should be warmed in the hands.

Side effect

• skin rash;
• itching;
• anaphylactic shock;
• hives;
• angioedema;
• malignant exudative erythema (Stevens-Johnson syndrome);
• toxic epidermal necrolysis (Lyell's syndrome);
• burning sensation in the epigastric region;
• dry mouth;
• headache;
• dizziness;
• paresis of accommodation;
• thrombocytopenia, leukopenia, agranulocytosis (may be manifested by fever, chills, sore throat, difficulty swallowing, stomatitis, vaginitis,proctitis);
• bronchospasm (especially in predisposed patients);
• tachycardia;
• a decrease in blood pressure;
• oliguria, anuria;
• proteinuria;
• interstitial nephritis;
• staining the urine in red (due to Metamizol metabolites);
• difficulty urinating;
• when administered intramuscularly, infiltrates are possible at the site of administration;
• decreased sweating.

Contraindications

• severe liver dysfunction;
• severe renal dysfunction;
• genetic deficiency of glucose-6-phosphate dehydrogenase;
• tachyarrhythmia;
• angle-closure glaucoma;
• hyperplasia of the prostate (with clinical manifestations);
• oppression of bone marrow hematopoiesis;
• intestinal obstruction;
• megacolon;
• collapse;
• acute porphyria;
• granulocytopenia;
• chronic heart failure in the stage of decompensation;
• stable and unstable angina;
• pregnancy (1 trimester and the last 6 weeks);
• lactation period (breastfeeding);
• hypersensitivity to pyrazolone derivatives and other components of the drug.

Maxigan in the form of tablets is not prescribed for children under 5 years of age.

Solution for injection is not prescribed for children under 3 months of age or with a body weight of less than 5 kg.

Application in pregnancy and lactation

Maxigan is contraindicated in pregnancy (1 trimester and the last 6 weeks) and during lactation (breastfeeding).

Use in children

Solution for injection is not prescribed for children under 3 months of age or with a body weight of less than 5 kg.

Maxigan in the form of tablets for oral administration is prescribed for adolescents over 15 years 1-2 tablets 2-3 times a day. The maximum daily dose is 6 tablets. Duration of reception - no more than 5 days.

Children aged 6-8 years are prescribed 1/2 tablet, children aged 9-12 years - 3/4 tablets, children aged 13-15 years - 1 tablet. Multiplicity of reception - 2-3 times a day.

For children, the drug is administered intramuscularly or intravenously, depending on the age and body weight.

special instructions

With caution and under the supervision of a doctor, the drug should be prescribed for violations of liver or kidney function, with a predisposition to arterial hypotension (systolic pressure less than 100 mm Hg), bronchospasm, with increased sensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) or non-opioid analgesics (in including those with a history of "aspirin triad").

With prolonged (more than 1 week) use of the drug, it is necessary to control the picture of peripheral blood (the number of leukocytes and platelets) and the functional state of the liver. If suspicion of agranulocytosis or thrombocytopenia, the use of Maxigan should be discontinued.

Solution for injection is not used to stop acute abdominal pains until the cause is clarified.

Parenteral administration of the drug is used in emergency cases (for example, renal or hepatic colic) and in those cases when taking the drug inside is not possible. With caution should be carried out in / in the introduction of the drug (because there is a risk of developing arterial hypotension). I / O administration should be slow, the patient should be in a prone position, it is necessary to monitor blood pressure, heart rate and respiratory rate.

When using Maxigan, avoid drinking alcohol.

Radiocontrast agents and colloidal blood substitutes should not be used during treatment with drugs containing metamizole sodium.

Impact on the ability to drive vehicles and manage mechanisms

During the period of taking the drug, it is not recommended to drive vehicles and engage in other potentially dangerous activities requiring rapidity of psychomotor reactions.

Drug Interactions

With the simultaneous use of Maxigan with other non-opioid analgesics, there is a mutual increase in toxic effects.

Tricyclic antidepressants, oral contraceptives, Allopurinol disrupt metamizole sodium metabolism and increase its toxicity.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole sodium.

With simultaneous application of Maxigan with cyclosporine, the level of the latter in the blood decreases.

Sedatives and tranquilizers increase the analgesic effect of metamizole sodium.

With the simultaneous appointment of Maxigan with blockers of histamine H1 receptors, butyrophenones, phenothiazines, amantadine and quinidine, m-cholinoblocking action may be enhanced.

With simultaneous use with ethanol (alcohol), there is a mutual enhancement of effects.

With the simultaneous use of Maxigan with chlorpromazine or other phenothiazine derivatives, it is possible to develop pronounced hyperthermia.

Metamizole sodium, displacing from the bond with protein oral hypoglycemic drugs, indirect anticoagulants, GCS and Indomethacin can enhance their clinical effects.

With the simultaneous use of Maxigan with thiamazole and cytostatics, the risk of developing leukopenia increases.

With simultaneous use of codeine, blockers of histamine H2-receptors, Propranolol slows the inactivation of metamizole sodium and enhances its effect.

Pharmaceutical interaction

Solution for injection is not pharmaceutically compatible in one syringe with solutions of other medications.

Analogues of the drug Maxigan

Structural analogs for the active substance:

• Baralgetas;
• I took it;
• Bralangin;
• Geomag;
• Plenalgin;
• Revalgine;
• Renalgan;
• Spasgan;
• Spazmalgon;
• Spazmaline;
• Spasmaton;
• Spazmoblok;
• Spasmopharm;
• Trinalgin.

Analogues for the pharmacological group (NSAIDs of pyrazolones):

• Analgin;
• Analgin solution in ampoules;
• Andipal;
• Baralgetas;
• Baralgin M;
• Benalgin;
• Bralangin;
• I took it;
• Geomag;
• Quatrox;
• Metamizol sodium;
• Optalgin;
• Otypax;
• Otyrerelax;
• Pentafuphene;
• Pentalgin;
• Pentalgin H;
• Pentans;
• Pentanov H;
• Pepper plaster Doctor pepper with analgesic action;
• Piralgin;
• Plenalgin;
• Propyphenazone;
• Revalgine;
• Renalgan;
• Santoperalgin;
• Santotitralgin;
• Sedal M;
• Sedalgin Neo;
• Sedalgin Plus;
• Spasgan;
• Spasdulzin for children;
• Spazmalgon;
• Spazmaline;
• Spasmaton;
• Spazmoblok;
• Spasmopharm;
• Tempalgin;
• Tempanginol;
• Tetralgin;
• Tetralgin H;
• Trialgin;
• Trinalgin;
• Folikap.

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