Erythropoietin - instructions for use, analogs, reviews and release forms (injections in ampoules for injection in a solution of 500 IU and 2000 IU) of a drug for the treatment of anemia, including aplastic in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Erythropoietin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Erythropoietin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Erythropoietin in the presence of existing structural analogues.Use for the treatment of anemia, including aplastic in adults, children (including prematurity), as well as during pregnancy and lactation. Composition of the drug.

Erythropoietin - recombinant human erythropoietin (purified glycoprotein), which is a hematopoietic growth factor. Obtained by the method of genetic engineering. Increases the number of erythrocytes, reticulocytes, stimulates the synthesis of hemoglobin in cells. Has no effect on leukopoiesis. It is believed that erythropoietin interacts with specific erythropoietin receptors on the cell surface.

Composition

Epoetin beta + auxiliary substances.

Pharmacokinetics

After subcutaneous administration, Cmax in plasma is reached after 12-28 hours. The half-life in the final phase is 13-28 hours.

After intravenous administration of T1 / 2 active substance is 4-12 hours.

Indications

• severe anemia, which appears against the background of chronic renal failure;
• anemia with bone marrow lesions and some chronic diseases (including aplastic anemia, anemia in myelodysplastic diseases, chronic inflammatory diseases, AIDS, cancer);
• prevention of anemia in premature newborns born with a body weight of 750-1500 g until the 34th week of pregnancy;
• to increase the volume of donor blood, intended for subsequent autotransfusion in order to avoid blood transfusions.

Forms of release

Solution for intravenous and subcutaneous administration of 500 IU and 2000 IU (injections in ampoules for injections).

Instructions for use and dosing regimen

Doses, the scheme and duration of treatment are set individually, depend on the severity of anemia, the severity of the patient's condition, the nature of the disease. Enter subcutaneously and intravenously. Initial doses - 50-150 IU / kg, the frequency of administration - an average of 3 times a week.

Side effect

• arterial hypertension;
• hypertensive crisis;
• encephalopathy (more often with hypertensive crises);
• headache;
• confusion of consciousness;
• thrombocytosis;
• thrombotic complications;
• hyperkalemia;
• skin rash;
• anaphylactoid reactions.

Contraindications

• uncontrolled arterial hypertension;
• a previous myocardial infarction or stroke of the brain during the previous month;
• unstable angina;
• a thromboembolism in the anamnesis;
• hypersensitivity to epoetin beta.

Application in pregnancy and lactation

In pregnancy and during lactation, Erythropoietin is used only if the intended benefit of treatment for the mother exceeds the potential risk of side effects in the mother, fetus or child. In experimental studies, teratogenic action was not detected.

Use in children

Not noted.

special instructions

Use with caution in epilepsy, thrombocytosis, liver failure, vascular insufficiency, with malignant neoplasms; in patients with nephrosclerosis who are not receiving hemodialysis, since a more rapid deterioration in kidney function is possible.

The effectiveness of treatment decreases with iron deficiency in the body, with infectious and inflammatory diseases, hemolysis.

The drug is classified as doping for the purposes of professional sports.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, one should refrain from occupations requiring increased attention and speed of psychomotor reactions.

Drug Interactions

With the simultaneous use of drugs that affect hematopoiesis (such as iron preparations), the stimulating effect of Erythropoietin can be enhanced.

Analogues of the drug Erythropoietin

Structural analogs for the active substance:

• Vero Epoetin;
• Recormon;
• Epostim;
• Epoetin;
• Epoetin beta;
• Erythropoietin alfa is a human recombinant;
• Erythrostim.

Analogues on the pharmacological group (stimulators of hemopoiesis):

• Actyferrin;
• Aktiferrin compositum;
• Aeprin;
• Betaleukin;
• Binocrit;
• Biofer;
• Venofer;
• Wialfer;
• Hematogen;
• Hemofer;
• Gino Tardiferon;
• Iron gluconate 300;
• The iron fumarate;
• Iron sulfate;
• Iron polymaltose;
• The Immigra;
• Interleukin 1 beta;
• CosmoFer;
• Leukogen;
• Leukomax;
• To the Leichest;
• Leucite;
• Maltofer;
• Maltofer Foul;
• Methyluracil;
• Monofer;
• Neupogen;
• Neuromax;
• Neutrostim;
• Neostimium;
• Unstable;
• Normosang;
• Nucleospermate sodium;
• Panagen;
• Pentoxyl;
• Polydane;
• The Revolade;
• Sorbifer Durules;
• Tardiferon;
• Tevagrastim;
• Fenules 100;
• Ferlatum;
• Ferrinate;
• Ferro Folgamma;
• Ferrograduum;
• Ferronal;
• Ferroplex;
• Ferrum Lek;
• Filgrastim;
• Filerim;
• Folacin;
• Folic acid;
• Heferol;
• Ceruloplasmin;
• Cyanocobalamin;
• Epokrin;
• Epomax;
• Eporati;
• Epostim;
• Epoetin;
• Epoetin beta;
• Eprex;
• Eralfon;
• Erythropoietin alfa is a human recombinant;
• Erythrostim.

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