Griseofulvin - instructions for use, analogs, reviews and release forms (125 mg tablets, liniment or ointment Farkos) drugs for the treatment of skin fungus, nails, dermatophytosis, favus in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Griseofulvin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Griseofulvin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Griseofulvin analogs in the presence of existing structural analogues. Use to treat fungus skin, nails, dermatophytosis, favus in adults,children, as well as during pregnancy and lactation. Composition of the preparation.

Griseofulvin antifungal antibiotic. It has a fungistatic effect. It is active against dermatophytes of the genera Trichophyton, Microsporum, Epidermophyton. Inhibits the cell division of fungal cells in the metaphase, disrupting the structure of the mitotic spindle. Griseofulvin accumulates in varying degrees in the cells of the skin, hair and nails, which are the precursors of keratin, making keratin resistant to fungal infestation. As the isolation of infected keratin is replaced by a healthy tissue.

Composition

Griseofulvin + excipients.

Griseofulvin + Salicylic acid + auxiliary substances (Griseofulvin Farkos).

Indications

Dermatophytosis of the scalp, smooth skin and nails caused by susceptible to the preparation fungi, including:

• microsporia (ringworm);
• trichophytosis;
• favus.

Epidermophytia of the feet and brushes, caused by Trichophyton rubrum, Trichophyton interdigitale.

Forms of release

Tablets 125 mg.

Liniment Griseofulvin Farkos (sometimes mistakenly called ointment or cream).

Other dosage forms, be it a solution, shampoo or suspension, do not exist.

Instructions for use and how to use them

Pills

In microsporia, the daily intake for adults is up to 1000 mg (8 tablets), children are prescribed at the rate of 21-22 mg / kg of body weight per day. The drug should be taken daily until the first negative mycological analysis, and then in the same dose take 2 weeks every other day and 2 weeks 2 times a week.

With onychomycosis, trichophytosis and paw paws, the daily dose of the drug for adults weighing up to 50 kg is 625 mg (5 tablets), then for every 10 kg of body weight the dose of the drug is increased by 125 mg (1 tablet). The maximum daily dose is 1 g (8 tablets)

With trichophytosis and favus, the drug is prescribed to children at a rate of 18 mg / kg of body weight per day. The course of treatment is carried out as in microsporia.

With onychomycosis for children and adolescents, the drug is prescribed at the rate of 16 mg / kg body weight.

With onychomycosis, the drug is prescribed during the first month every day, the second month - every other day, then 2 times a week until the nail is completely replaced with a healthy one. The total duration of treatment should be at least 8 months.

Tablets should be taken during meals with vegetable oil (1 teaspoon).

Liniment

Outerly, apply a thin layer on the affected skin 1-2 times a day.The daily dose of ointment should not exceed 20 grams, cream - 30 g.

With smooth skin dermatomycosis, ointment or cream is applied to the affected skin 1-2 times a day for 2-3 weeks, with microsporia of the scalp - for 2-4 weeks.

With onychomycosis, the ointment is applied to the cleared lesions of the nails for 2 weeks daily, and then 1 time every 2 days until the nail is completely changed. When the surgical removal of the affected nail on the nail bed is applied 1 time in 2 days (until the healthy nail grows).

Side effect

• dyspepsia;
• headache;
• dizziness;
• disorientation;
• leukopenia, leukocytosis, eosinophilia;
• hives;
• skin rash.

Contraindications

• abnormal liver function;
• impaired renal function;
• changes in the morphological composition of the blood;
• porphyria;
• malignant tumors;
• uterine bleeding;
• systemic lupus erythematosus;
• impaired cerebral circulation (including in the anamnesis);
• pregnancy;
• lactation period;
• children under 14 years (for liniment);
• increased sensitivity to griseofulvin.

Application in pregnancy and lactation

Griseofulvin is contraindicated in pregnancy and lactation.

Use in children

Children are recommended to prescribe multivitamins in conjunction with Griseofulvin.

The use of the drug in the form of liniment is prohibited in children under the age of 14 years.

special instructions

When applying Griseofulvin it is necessary to monitor the morphological composition of the blood once every 10-15 days.

If allergic reactions occur, antiallergic therapy should be prescribed. When the severity of manifestations of allergic reactions increases, the drug should be canceled for 3-4 days. After the disappearance of the manifestations, the drug should be prescribed again, starting with 1/2 tablet a day and gradually for 3-4 days, increasing it to therapeutic.

In the process of treating the dermatophytosis of the scalp, you need to shave your hair weekly and wash your hair with warm water and soap twice a week. Treatment Griseofulvin should be combined with external use of antifungal drugs.

With onychomycosis, it is recommended to combine the use of Griseofulvin with the removal of affected nails with keratolytic patches and local antifungal therapy.

Ointment is not recommended for prescription.

Impact on the ability to drive vehicles and manage mechanisms

Patients taking Griseofulvin should refrain from engaging in potentially dangerous activities that require increased attention and speed of psychomotor reactions.

Drug Interactions

During the treatment should be avoided taking ethanol (alcohol).

Analogues of the drug Griseofulvin

Structural analogs for the active substance:

• Griseofulvin Farkos;
• Fulcin.

Analogues on the curative effect (agents for the treatment of mycosis nails):

• Amphotericin B;
• Anmarine liniment 1%;
• Anmarine solution 0.25%;
• Atitis;
• Batrafen;
• Binafin;
• Bifonazole cream 1%;
• Bifonazole powder 1%;
• Bifonazole solution 1%;
• Griseofulvin Farkos;
• Dactanol;
• Diflason;
• Diflucan;
• Itrazole;
• Itraconazole;
• Itramikol;
• Iphenec;
• Ketoconazole;
• Lamisyl;
• Lamican;
• Loceril;
• Mikoderil;
• Mikozan set to remove fungal lesions from the nail plate;
• Mikozolone;
• Mycosorrhal;
• Mycomomax;
• Miconazole;
• Mycosyst;
• Mycospores;
• Mycospores Set;
• Mycoflucan;
• Nizoral;
• Nofung;
• Onyelp;
• Orungal;
• Offlomil Luck;
• Rumikoz;
• Terbisyl;
• Terbinafine;
• Thermic;
• Trozid;
• Fluconazole;
• Flucostat;
• Fulcin;
• Fungolon;
• Fungoterbine;
• Exifin;
• Exodermil.

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