Seduxen - instructions for use, analogs, reviews and release forms (5 mg tablets, injections in ampoules for injections) drugs for the treatment of psychoses, neuroses, insomnia, tics in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Seduxen. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Seduxen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Seduxen in the presence of existing structural analogs. Use to treat psychoses, neurotic disorders or neuroses, insomnia, tics in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Seduxen - a tranquilizer, a benzodiazepine derivative. Has anxiolytic, sedative, anticonvulsant, central muscle relaxant effect. The mechanism of action is associated with increased inhibitory effect of GABA in the central nervous system. The miorelaksiruyuschee effect is due also to the inhibition of spinal reflexes. Can cause an anticholinergic effect.

Composition

Diazepam + excipients.

Pharmacokinetics

Suction fast. Cmax in plasma is observed after 90 minutes. Binding to plasma proteins is 98%. It penetrates through the placental barrier, into the cerebrospinal fluid, and is excreted in breast milk. Metabolised in the liver. It is excreted by the kidneys - 70%.

Indications

• neuroses;
• borderline states with the phenomena of tension, anxiety, anxiety, fear;
• sleep disorders (insomnia);
• motor excitation of various etiologies in neurology and psychiatry;
• abstinence syndrome in chronic alcoholism;
• spastic conditions associated with the defeat of the brain or spinal cord, as well as myositis, bursitis, arthritis, accompanied by a strain of skeletal muscles;
• status epilepticus;
• premedication before anesthesia;
• as a component of combined anesthesia;
• facilitating labor activity;
• premature delivery;
• premature placental abruption;
• tetanus.

Forms of release

Tablets 5 mg.

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

Instructions for use and recommended doses

Pills

The dose of the drug is selected individually, and it is necessary to take into account both the patient's condition and the response to treatment - only general instructions are given below. At the beginning of therapy it is recommended to apply small doses of the drug with a gradual increase. Separate the daily dose for 2-4 admission is necessary individually. It is advisable to take 2/3 of the daily dose in the evening.

Adults, neurological disorders, psychosomatic diseases, anxiety-phobic disorders: usual single dose - 2.5-5 mg (1 / 2-1 tablets). The average daily intake for adults is 5-20 mg.

Single dose should not exceed 10 mg.

Symptomatic treatment of convulsive syndrome: usually 2.5-10 mg (1 / 2-2 tablets) 2-4 times a day.

In the complex treatment of mental disorders of organic origin: an initial dose of 20-40 mg (4-8 tablets) per day, supporting a daily dose of 15-20 mg (3-4 tablets).

Muscular contractures, spasticity, rigidity - 5-20 mg (1-4 tablets) per day.

In elderly and cachectic patients, as well as with a decrease in liver function, excretion of Seduxen may be significantly prolonged. It is recommended to begin treatment with a lower (approximately half) dose, which can be gradually increased, taking into account the individual tolerance of the drug.

The dose for children should always be determined individually, taking into account age, level of physical development, general condition and response to ongoing treatment. The initial dose for children is 1.25-2.5 mg per day, divided into 2-4 doses. This dose can be reduced or increased, taking into account the individual reaction to the therapy.

Children up to 6 months of use of anxiolytic drugs from the benzodiazepine group is not allowed.

Solution for intravenous and intramuscular injection

It is forbidden to enter extravasely (except for intramuscularly) and in the artery! Enter deep into the muscle with the / m application. In a vein to enter slowly: no more than 5 mg (1 ml) of a preparation within 1 minute, tk. a rapid introduction can cause apnea. Children to enter very slowly: more than 3 minutes.

In connection with the presence of significant individual differences in the response to the drug,treatment should begin with the lowest effective dose, gradually increasing it until the least effective and at the same time sufficiently tolerated dose is reached.

Stimulation of psychomotor agitation proceeding with anxiety - 10-20 mg intramuscularly, in severe cases - intravenously, if necessary - 10 mg 3-4 times a day.

Alcohol abstinence syndrome, delirium, conditions that occur with an increase in muscle tone - no more than 10 mg 3-4 times a day, IM.

For tetanus - 10-20 mg IM or IV (including drip in the form of a dropper), every 2-8 hours, depending on the clinical picture.

With epileptic status - the initial dose is 10-30 mg IV, which can be repeated after 0.5-1 h, then after 4 hours. The maximum daily dose is 80-100 mg. After cessation of seizures, you can go to the / m introduction (10 mg every 4-6 hours, if necessary - for several days).

For the removal of spasm of skeletal muscles - for 0.5 h before the operation - no more than 10 mg, IM.

Newborns older than 5 weeks (older than 30 days) - 0.1-0.3 mg / kg body weight IV, slowly. The maximum dose is 5 mg. If necessary, depending on the clinical picture, after 2-4 hours the injection can be repeated, however, the administration of more than 3 injections per day is permissible only in the case of tetanus and epileptic status.Except for absolute indications - epilepsy, tetanus - administration of the drug to children under 6 years is not recommended due to age-related features of distribution, metabolism and safety of use.

Children older than 5 years - 1 mg IV every 2-5 minutes to a maximum dose of 0.2 mg / kg (with convulsions - up to 0.3 mg / kg), if necessary, after 2-4 hours treatment can be repeated. With the increase in epileptic seizures and the epileptic status of the dose, the initial dose is 2-10 mg IV, then 0.5-1 hours later, after 4 hours the dose can be repeated. The introduction of more than 3 injections per day is permissible only in the case of tetanus and epileptic status.

Side effect

• drowsiness;
• dizziness;
• muscle weakness;
• confusion of consciousness;
• depression;
• visual impairment;
• diplopia;
• dysarthria;
• headache;
• tremor;
• ataxia;
• excitation;
• sense of anxiety;
• sleep disorders;
• hallucinations;
• hiccough;
• development of drug dependence (with prolonged use);
• memory impairment;
• constipation;
• nausea;
• dry mouth;
• salivation;
• increased activity of transaminases and alkaline phosphatase in the blood plasma;
• jaundice;
• increased or decreased libido;
• urinary incontinence;
• with parenteral application, some decrease in blood pressure is possible;
• breathing disorders;
• skin rash.

Contraindications

• severe myasthenia gravis;
• severe chronic hypercapnia;
• indication in the history of alcohol or drug dependence (except acute withdrawal);
• increased sensitivity to diazepam and other benzodiazepines.

Application in pregnancy and lactation

Do not use Seduxen Diazepam in the 1st trimester of pregnancy, except in cases of extreme necessity. It should be borne in mind that with the use of diazepam in pregnancy, a significant change in the fetal heart rate is possible.

When used in obstetrics in doses recommended for the relief of labor, in newborns, more often in premature babies, temporary hypotension, hypothermia, and respiratory failure are possible.

With regular admission during lactation, breastfeeding should be discontinued.

Use in children

It is necessary to avoid the use of Seduxen in newborns, since they have not yet fully formed the enzyme system involved in the metabolism of diazepam.

special instructions

With extreme caution apply in patients with cardiac and respiratory insufficiency, organic changes in the brain (in such cases, it is recommended to avoid parenteral diazepam administration), with angle-closure glaucoma and predisposition to it, with myasthenia gravis.

Special care is required when using Seduxen, especially at the beginning of treatment, in patients who have been receiving long-term antihypertensive drugs of central action, beta-adrenoblockers, anticoagulants, cardiac glycosides.

If you cancel therapy, the dose should be reduced gradually. With sudden withdrawal of diazepam after prolonged use, anxiety, agitation, tremors, convulsions are possible.

Seduxen should be abolished with the development of paradoxical reactions (acute agitation, anxiety, sleep disturbances and hallucinations).

After intravenous injection of diazepam, an increase in the activity of CK in the blood plasma is possible (which should be taken into account in the differential diagnosis of myocardial infarction).

Avoid intraarterial administration.

During the treatment period, do not drink alcohol.

It is released by prescription.

Impact on the ability to drive vehicles and manage mechanisms

Seduxen may cause a slowdown in the rate of psychomotor reactions, which should be taken into account for patients engaging in potentially hazardous activities.

Drug Interactions

When used simultaneously with drugs that exert a depressing effect on the central nervous system (including neuroleptics, sedatives, hypnotics, opioid analgesics, anesthetics), the oppressive effect on the central nervous system, on the respiratory center, and severe arterial hypotension increases.

With simultaneous use with tricyclic antidepressants (including with amitriptyline), it is possible to increase the oppressive effect on the central nervous system, increase the concentration of antidepressants, and increase cholinergic action.

Patients who received long-term antihypertensive drugs of central action, beta-blockers, anticoagulants, cardiac glycosides, degree and mechanisms of drug interaction are unpredictable.

With simultaneous use with muscle relaxants, the effect of muscle relaxants is increased, the risk of apnea increases.

When used simultaneously with oral contraceptives, it is possible to enhance the effects of diazepam.Increased risk of development of breakthrough bleeding.

With simultaneous use with bupivacaine may increase the concentration of bupivacaine in blood plasma; with Diclofenac - may increase dizziness; with Isoniazid - a reduction in the excretion of diazepam from the body.

Drugs that induce induction of liver enzymes, incl. antiepileptic drugs (carbamazepine, phenytoin), can accelerate the excretion of diazepam.

With simultaneous use with caffeine, the sedative and, perhaps, the anxiolytic effect of diazepam decreases.

With simultaneous application with clozapine, arterial hypotension, respiratory depression, loss of consciousness are possible; with levodopa - suppression of antiparkinsonian action is possible; with lithium carbonate - a case of development of a coma is described; with Metoprolol - reduction of visual acuity, deterioration of psychomotor reactions are possible.

With simultaneous application with paracetamol, a decrease in the excretion of diazepam and its metabolite (desmethyldiazepam) is possible; with Risperidone - cases of ZNS development are described.

With simultaneous use with rifampicin, the excretion of diazepam increases due to a significant increase in its metabolism underinfluence of rifampicin.

Theophylline in low doses, perverts the sedative effect of Seduxen.

With the simultaneous use in rare cases, diazepam inhibits metabolism and enhances the effect of phenytoin. Phenobarbital and phenytoin can accelerate the metabolism of diazepam.

With simultaneous application of fluvoxamine increases the concentration in the blood plasma and side effects of diazepam.

With simultaneous use with cimetidine, omeprazole, disulfiram, an increase in the intensity and duration of action of diazepam is possible.

With the simultaneous use of ethanol (alcohol) or ethanol-containing drugs, the oppressive effect on the central nervous system (mainly the respiratory center) increases, and a syndrome of pathological intoxication may also occur.

Analogues of the drug Seduxen

Structural analogs for the active substance:

• Apaurin;
• Valium Rosh;
• Diazepabene;
• Diazepam;
• Diazepec;
• Diapam;
• Relanium;
• Relium;
• Sibazon.

Analogues on the pharmacological group (anxiolytics or tranquilizers):

• Adaptol;
• Alzolam;
• Alprazolam;
• Alprox;
• Anvifen;
• Atarax;
• Afobazol;
• Bromazep;
• Bromide;
• Hydroxysine;
• Grandaxin;
• Diazepam;
• Diazepec;
• Diamidazepam;
• Zolomax;
• Ipronal;
• Kassadan;
• Xanax;
• Xanax retard;
• Lexotan;
• Librax;
• Lorazepam;
• Loram;
• Laurafen;
• Mebicar;
• Mebiks;
• Mezapam;
• Mexiprim;
• Mexicin;
• Miolastane;
• Napoton;
• Neurophasole;
• Neurol;
• Nobrethum;
• Nozepam;
• Noophen;
• Oxazepam;
• Rudotel;
• Selanc;
• Sibazon;
• Spitomin;
• Stresam;
• Tazepam;
• Tenoten;
• Tenoten for children;
• Tofizopam;
• Tranquesipam;
• Tranxen;
• Phenazepam;
• Fenzitate;
• Fenibut;
• Phenorelaxane;
• Helex;
• Elenium;
• Elzepam.

Similar medicines:

Other medicines: