Clomid - instructions for use, reviews, analogs and forms of release (tablets 50 mg) drugs to treat infertility and stimulate ovulation in women with ovarian hypofunction. Composition

In this article, you can read the instructions for using the drug Clomid. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Clomid in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Clomid in the presence of existing structural analogues. Use to treat infertility and stimulate ovulation in women with ovarian hypofunction, as well as during pregnancy and lactation. Composition of the preparation.

Clomid - blocks estrogen receptors in the hypothalamus and ovaries, enhances the secretion of the gonadotrophic hormones (LH, FSH) by the pituitary gland, which stimulates the maturation and endocrine activity of the follicle; as a consequence - stimulates ovulation and increases the concentration of estradiol in the blood.

Composition

Clomiphene citrate + auxiliary substances.

Pharmacokinetics

Clomiphene is rapidly absorbed from the digestive tract. Undergoes intestinal-hepatic recirculation. It is excreted mainly with feces - 42% and about 8% with urine.

Indications

• to stimulate ovulation infertility due to secondary ovarian hypofunction, mainly due to functional hypothalamic-pituitary disorders;
• functional uterine bleeding;
• secondary amenorrhea or pronounced oligomenorrhoea;
• polycystic ovary syndrome (of the Stein-Levental type);
• androgen insufficiency;
• Chiari-Frommel syndrome.

Forms of release

Tablets 50 mg.

Instructions for use and dosage

Inside, the recommended dose for the first cycle is 50 mg 1 time per day for 5 days, starting from the 5th day of the menstrual cycle. In the case of ovulation, there is no need to increase the dose on subsequent cycles of treatment.

In the absence of effect, the second cycle of treatment is prescribed (not earlier than 30 days after the first) at a dose of 100 mg for 5 days; An increase in the dose or duration of treatment should not be performed.

An effective full course for the majority of patients is 3 cycles. In the absence of effect, further continuation of treatment is not advisable.

Side effect

• headache;
• dizziness;
• nausea;
• tides;
• visual impairment;
• cystic enlargement of the ovaries.

Contraindications

• severe hepatic-renal insufficiency;
• uterine bleeding of unclear etiology;
• ovarian cyst;
• tumor or deficiency of pituitary gland function;
• pregnancy.

Application in pregnancy and lactation

Use of the drug Clomid is contraindicated in pregnancy and lactation (breast-feeding).

Use in children

Contraindicated use in children.

special instructions

Before and during treatment, constant monitoring of the gynecologist is necessary, ovarian function should be checked, vaginal examinations should be performed, the phenomenon of "pupil" and others should be observed. When enlarging the ovaries or their cystic transformation, treatment with clomiphene is suspended until the ovaries are normalized.Therapy is continued with the use of minimal doses or shorten the period of treatment.

Against the background of treatment it is recommended to monitor liver function.

Impact on the ability to drive vehicles and manage mechanisms

It is impossible to appoint persons without the exemption from work whose professional activity requires quick physical and mental reactions.

Drug Interactions

Clomid blocks estrogen receptors and weakens the action of hexestrol.

Compatible with preparations of gonadotropic hormones.

Analogues of the drug Clomid

Structural analogs for the active substance:

• Clomiphene;
• Clostilbite;
• Serofen;
• Serpafar.

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