Cyclovir - instructions for use, analogs, reviews and release forms (200 mg tablets, cream or ointment 5%) of the drug for the treatment of herpes, shingles, chickenpox in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Cyclovir. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ciclovir in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ciclovir with available structural analogues. Use for the treatment of herpes, shingles, chickenpox or chickenpox in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Cyclovir - interacts with enzymes of virus infected host cells (has structural similarity with DNA deoxyguanidine) and stops replication of the virus. Has a selective effect on the synthesis of viral DNA.

It is active against the Herpes simplex virus types 1 and 2, the Varicella zoster virus, the Epstein-Barr virus and cytomegalovirus.

Composition

Acyclovir + excipients.

Pharmacokinetics

When administered, the bioavailability is 15-30%. Widely distributed in the tissues and body fluids, penetrates the blood-brain barrier (BBB). Binding to plasma proteins is 9-33%. Metabolised in the liver. It is excreted in the urine, in a small amount - with feces.

Indications

• infections of the skin and mucous membranes caused by the herpes simplex virus or the herpes zoster virus;
• herpes lips or genitals.

Forms of release

Tablets 200 mg.

Cream for external use 5% (sometimes mistakenly called ointment or gel).

Other dosage forms, be it suspension, syrup, solution or capsules at the time of publication of the drug in the Directory did not exist.

Instructions for use and dosing regimen

Pills

Inside, the course - 5 days (with shingles - additionally within 3 days).

Adults and children over 5 years of age: for infections caused by the herpes simplex virus, 200 mg 5 times a day (for prevention, 200 mg 4 times a day); at a shingling deprive - on 800 mg 5 times a day. Children under 2 years - 1/2 dose of adults.

Prophylactic (with organ transplant and other diseases) use is determined by the period of risk - usually 6 weeks.

Cream

Nakozhno, on the affected surface 5 times a day with an interval of 4 hours. Course - 5-10 days.

Side effect

• nausea, vomiting;
• diarrhea;
• headache;
• increased fatigue;
• increase in urea, creatinine and bilirubin in the blood serum;
• increased activity of liver enzymes;
• allergic skin reactions;
• irritation in the place of application of the cream.

Contraindications

• increased sensitivity to acyclovir and valacyclovir;
• children under 5 years (for tablets).

Application in pregnancy and lactation

The use of Ciclovir in pregnancy is possible in cases where the intended benefit to the mother exceeds the potential risk to the fetus.

In experimental animal studies, it has been shown that Acyclovir penetrates the placental barrier.

Use in children

Contraindicated in children under 5 years (in the form of tablets).

special instructions

It is not recommended to use tablets for the treatment of newborns.

In the treatment with Ciclovir, a large amount of liquid is recommended (to prevent the formation of a precipitate of acyclovir in the renal tubules).

Not to be confused with the drug Citovir 3, which is used to treat and prevent ARVI and influenza.

The toxic effect of acyclovir on the CNS is more likely in patients with impaired immunity, in elderly patients, using high doses.

Ciclovir therapy in clinical practice recorded thrombocytopenic purpura and / or hemolytic uraemic syndrome, in rare cases with a fatal outcome, in patients with clinically expressed forms of HIV infection.

It is not recommended for prescribing to children for the treatment of chicken pox if the disease is mild.

In the treatment of genital herpes, sexual intercourse should be avoided or condoms should be used. The use of Ciclovir does not prevent the transmission of the virus to the partner.

Cream and ointment for external use (5%) is not recommended to be applied to the mucous membranes of the mouth and eyes. possible development of pronounced local inflammation.

Drug Interactions

With the simultaneous use of probenecid reduces the tubular secretion of acyclovir and thereby increases the concentration in the blood plasma and T1 / 2 acyclovir.

When used simultaneously with mycophenolate mofetil increases the AUC of acyclovir and an inactive metabolite of mycophenolate mofetil.

With the simultaneous use of Ciclovir with nephrotoxic drugs, the risk of developing nephrotoxic action increases (especially in patients with impaired renal function).

Analogues of the drug Ciclovir

Structural analogs for the active substance:

• Acigerpine;
• Acyclovir;
• Acyclostad;
• Vivorax;
• Virolex;
• Gervirax;
• Gerpevir;
• Gerperax;
• Herpes;
• Zovirax;
• Lysavir;
• The Medovar;
• Provirsan;
• Supperan;
• Cyclovax;
• Cycloviral;
• Cytivir.

Analogues on the curative effect (agents for the treatment of herpes):

• Alpisarin ointment;
• Amiksin;
• Anaferon;
• Anaferon child;
• Antigerpes;
• Arbidol;
• Acyclovir;
• Walogard;
• Valtrex;
• Valtsikon;
• Vectavir;
• Virazole;
• Wirdel;
• Virosept;
• Vitaherpavak;
• Viferon;
• Galavit;
• Gevisos;
• Herpferon;
• Groprinosin;
• Devirs;
• Zovirax;
• Isoprinosine;
• Immunomax;
• Kagocel;
• Kipferon;
• Lavomax;
• Lysavir;
• Lycopid;
• Lomagherpan;
• Lorinden C;
• Sodium nucleate;
• Neovir;
• Panavir;
• Supperan;
• Famvir;
• Fenistil Pencivir;
• Ferrovir;
• Cyclovax;
• Cycloferon;
• Epigenum sex;
• Erazaban;
• Ergoferon.

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