Zopiclone - instructions for use, reviews, analogs and forms of release (tablets of 3.75 mg and 7.5 mg) of the drug of sleeping pills for the treatment of insomnia and difficulties of falling asleep in adults, children and during pregnancy. Composition

In this article, you can read the instructions for the use of a hypnotic drug Zopiclone. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Zopiclone in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Zopiclone in the presence of existing structural analogues. Use to treat insomnia and difficulty falling asleep in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Zopiclone - hypnotics from the group of cyclopyrrolone derivatives.Nebenzodiazepine agonist of benzodiazepine receptors. It also has sedative, anxiolytic, central muscular-relaxing, anticonvulsant and amnestic properties. Like benzodiazepine derivatives, zopiclone enhances GABA-ergic processes in the brain, interacting with benzodiazepine receptors, which increases the sensitivity of GABA receptors to the mediator. However, zopiclone appears to interact with other sites of the benzodiazepine receptor than benzodiazepines.

Zopiclone reduces the time of falling asleep, reduces the number of nocturnal awakenings, increases the total duration of sleep. Virtually does not affect the structure of sleep, does not significantly reduce the amount of fast sleep. Phenomena have no or very few effects on awakening. Repeated receptions of zopiclone are not accompanied by cumulation.

In patients with nocturnal manifestations of bronchial asthma in combination with preparations of the methylxanthine series (theophylline), it reduces asthma attacks in the early pre-dawn hours, reduces their intensity and duration.

Composition

Zopiclone + auxiliary substances.

Pharmacokinetics

Quickly and completely absorbed from the digestive tract.Easily passes through the histohematological barriers, including the blood-brain barrier (BBB), and spreads to organs and tissues, including. brain. Do not cumulate.

Indications

• sleep disturbances (difficulty falling asleep, frequent nocturnal awakenings, early awakening);
• transient, situational and chronic insomnia;
• sleep disorders in mental disorders;
• bronchial asthma with night attacks (in combination with a one-time intake of a daily dose of theophylline).

Forms of release

Tablets 3.75 mg and 7.5 mg.

Instructions for use and dosage

Inside. The dose and duration of treatment is determined by the doctor strictly individually. The average dose is 7.5 mg once, at night, the maximum dose is 15 mg. Patients over 65 years of age, patients with liver disease or chronic respiratory failure, half the dose (3.75 mg) is recommended.

The course of treatment: from several days to 4 weeks.

Side effect

• sensation of bitter or metallic taste in the mouth;
• dry mouth;
• nausea, vomiting;
• dizziness;
• headache;
• drowsiness;
• confusion of consciousness;
• anterograde amnesia;
• hallucinations;
• nightmarish dreams;
• skin rash;
• addiction, drug dependence;
• withdrawal syndrome, incl. ricochet insomnia.

Contraindications

• severe respiratory failure;
• pregnancy (especially 1 and 3 trimester);
• lactation (breastfeeding);
• children and adolescence up to 15 years;
• increased sensitivity to zopiclone.

Application in pregnancy and lactation

Zopiclone is contraindicated in pregnancy and lactation (breastfeeding).

Use in children

Contraindicated in children under the age of 15 years.

special instructions

With caution appoint for severe hepatic insufficiency, myasthenia gravis.

The risk of drug dependence is minimal if the duration of zopiclone application does not exceed 4 weeks. However, there is a potential danger of dependence on zopiclone.

Cancellation should be carried out gradually, because With a sharp cessation of treatment, there may be a resumption of insomnia, frequent awakenings, headache and muscle pain, anxiety, agitation, distraction, irritability.

Paradoxical reactions are more often observed in elderly patients. When there are paradoxical reactions zopiclone should be canceled.

During the treatment should be excluded from drinking alcohol.

The drug is released by prescription.

Impact on the ability to drive vehicles and manage mechanisms

The next day after taking the drug, you should carefully drive the car and work with the mechanisms.

Drug Interactions

With simultaneous application reduces the concentration of trimipramine in the plasma and its effect.

Zopiclone enhances the effect of drugs that depress the central nervous system (including neuroleptics, other hypnotics, antiepileptic medicines, some antihistamines, alcohol).

Analogues of the drug Zopiclone

Structural analogs for the active substance:

• Imovan;
• Piklodorm;
• Relaxon;
• Somnol;
• Thorson.

Analogues on the pharmacological group (hypnotics):

• Andante;
• Berlidorm 5;
• Bromizoval;
• Valocordin;
• Heminearrin;
• Hypnogen;
• Diphenhydramine hydrochloride;
• Donormil;
• Dormikum;
• Zaleplon;
• Zolpidem;
• Zolsana;
• Iwadal;
• Imovan;
• Melaxen;
• Melarena;
• Melatonin;
• Nitrazadone;
• Nitrazepam;
• Nitram;
• Nitrust;
• Nitrosan;
• Onyria;
• Piklodorm;
• Radedorm;
• Reladorm;
• Relaxon;
• The Raslip;
• Rohypnol;
• Sanvall;
• Signopam;
• Snovitel;
• Somnol;
• Thorson;
• Phenobarbital;
• Phenobarbital tablets for children;
• Flormidal;
• Circadian;
• Estazolam;
• Eunotin.

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