Ascofen - instructions for use, analogs, reviews and release forms (tablets P painkillers) drug for the treatment of headache, dental pain in neuralgia, migraine in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Ascofen. There are reviews of visitors to the site - consumers of this anesthetic drug, as well as opinions of doctors of specialists on the use of Ascoffen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ascophene in the presence of existing structural analogues.Use for the treatment of headache, dental pain in neuralgia, migraine in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Ascofen - Combined drug, the effect of which is determined by the components that make up its composition.

Acetylsalicylic acid has an analgesic, antipyretic, anti-inflammatory effect associated with the suppression of COX-1 and -2, which regulate the synthesis of PG; inhibits the aggregation of platelets.

Caffeine increases the excitability of spinal cord reflex, excites the respiratory and vasomotor centers, dilates blood vessels in skeletal muscle, brain, heart, kidneys, reducing platelet aggregation; reduces drowsiness, a feeling of fatigue, increases mental and physical performance.

Paracetamol has an antipyretic, analgesic effect.

Composition

Acetylsalicylic acid + Paracetamol + Caffeine + auxiliary substances.

Indications

• moderately or poorly expressed pain syndrome (headache, toothache, neuralgia, myalgia, thoracic radicular syndrome, lumbago, arthralgia, algodismenorea, migraine) in adults;
• decrease in fever, with colds and other infectious and inflammatory diseases in adults and children over 15 years of age.

Forms of release

Pills.

Instructions for use and dosage

Inside, after eating. 1-2 tablets 2-3 times a day. The maximum daily dose is 6 tablets. The interval between doses of the drug should be at least 4 hours.

To reduce the irritant effect on the gastrointestinal tract, the drug should be taken after meals, washed down with water, milk, alkaline mineral water.

If there is a violation of the kidney or liver function, the break between doses is not less than 6 hours.

The drug should not be taken more than 5 days when prescribed as an anesthetic and more than 3 days - as an antipyretic. Other dosages and regimens are prescribed by the doctor.

Side effect

• anorexia;
• nausea, vomiting;
• gastralgia;
• diarrhea;
• erosive and ulcerative lesions of the gastrointestinal tract;
• gastrointestinal bleeding;
• hepatic and / or renal insufficiency;
• increased blood pressure;
• tachycardia;
• skin rash;
• angioedema;
• bronchospasm;
• dizziness;
• headache;
• visual impairment;
• noise in ears;
• reduction of platelet aggregation;
• hypocoagulation;
• hemorrhagic syndrome (nasal bleeding, gum bleeding, purpura and others);
• kidney damage with papillary necrosis;
• deafness;
• Stevens-Johnson syndrome;
• toxic epidermal necrolysis (Lyell's syndrome);
• Reye syndrome in children (metabolic acidosis disorders of the nervous system and psyche, vomiting, liver function disorders).

Contraindications

• hypersensitivity to acetylsalicylic acid or other NSAIDs or xanthines;
• hypersensitivity to other components of the drug;
• erosive and ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation), gastrointestinal bleeding;
• marked violations of the liver or kidneys;
• asthma induced by the use of acetylsalicylic acid, salicylates and other NSAIDs;
• hemorrhagic diathesis (von Willebrand's disease, hemophilia, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);
• exfoliating aortic aneurysm;
• deficiency of glucose-6-phosphate dehydrogenase;
• portal hypertension, vitamin K deficiency;
• increased excitability, sleep disturbance, anxiety disorders (agoraphobia, panic disorder);
• organic diseases of the cardiovascular system (acute myocardial infarction, severe course of coronary heart disease, arterial hypertension), paroxysmal tachycardia, frequent ventricular extrasystole;
• glaucoma;
• surgical interventions accompanied by bleeding;
• children's age till 15 years.

With caution: hyperuricemia, urate nephrolithiasis, gout, peptic ulcer and / or duodenal ulcer (in the anamnesis), heart failure of severe degree.

Application in pregnancy and lactation

Contraindicated in the use of Ascofen during pregnancy in the first and third trimester. In the 2nd trimester of pregnancy, one-time administration of the drug at recommended doses is possible only if the expected benefit for the mother does not exceed the potential risk to the fetus.

If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Use in children

Contraindicated in children under the age of 15 years.

special instructions

With continued use of the drug, control of peripheral blood and the functional state of the liver is necessary.Since Acetylsalicylic acid has an antiaggregant effect, the patient, if he is to undergo surgery, must warn the doctor in advance about taking the drug.

Acetylsalicylic acid in low doses reduces the excretion of uric acid. This can in some cases provoke a gout attack.

During treatment, you should stop using alcohol and alcohol-containing beverages (increased risk of gastrointestinal bleeding).

Acetylsalicylic acid has a teratogenic effect: when applied in the first trimester of pregnancy leads to malformations - the cleavage of the upper palate; in the third trimester - causes inhibition of labor (inhibition of PG synthesis), closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the small circulation.

Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the child due to a violation of the function of platelets.

The drug is not prescribed as an anesthetic for people under 18 years old, as an antipyretic agent - children under 15 years with acute respiratory diseases,caused by viral infections because of the danger of development of Reye's syndrome (encephalopathy and acute fatty liver dystrophy with acute development of hepatic insufficiency).

Drug Interactions

Enhances the effect of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic agents. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, anti-arthritis agents that promote the excretion of uric acid.

Increases the side effects of glucocorticosteroids (GCS), derivatives of sulfonylurea, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs (NSAIDs).

Avoid combination of the drug with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcohol-containing beverages (increases the risk of hepatotoxic effect).

Under the influence of paracetamol, the time of chloramphenicol elimination is increased by 5 times.

Caffeine accelerates the absorption of ergotamine.

Salicylamide, and other stimulators of microsomal oxidation contribute to the formation of toxic metabolites of paracetamol, which affect liver function.

Metoclopramide accelerates the absorption of paracetamol.With repeated admission, paracetamol can enhance the effect of anticoagulants (dicumarin derivatives).

Analogues of the drug Ascopen

Structural analogs for the active substance:

• Aquacitramone;
• Askofen P;
• Acifein;
• Co-plus;
• Migrenol Extra;
• Citramarin;
• Citramon;
• Citramon Ultra;
• Citrapar;
• Excerdine.

Analogues on the curative effect (funds for the treatment of migraine):

• Amigrenin;
• Amitriptyline;
• Analgin;
• Anaprilin;
• Andipal;
• Aspirin;
• Acetaminophen;
• Betalk;
• Vazobral;
• Diclofenac;
• Zomig;
• Zorex Morning;
• Ibufen;
• Caffetin;
• Ketonal;
• Corvitol;
• Metoprolol;
• MIG 200;
• Naklofen;
• Nalgezin;
• Next;
• Nilogrin;
• Noblessite;
• Novigan;
• NovoPassit;
• Nomigren;
• Nurofen;
• Nurofen for children;
• Obsidan;
• Omaron;
• Panadol;
• Paracetamol;
• Pentalgin;
• Pikamilon;
• Pliwalgin;
• Propranolol;
• Revalgine;
• Rudotel;
• Solpadein;
• Stugeron;
• Sumygamren;
• A sedative (sedative) collection;
• Faspik;
• Fezam;
• Flamax;
• Hyrumat;
• Cefexon;
• Cinnarizine;
• Egilok;
• Egilok Retard;
• Efkamon.

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