Imovan - instructions for use, analogs, reviews and release forms (7.5 mg tablets) hypnotics for the treatment of insomnia and difficulties with falling asleep in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Imovan. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of sleeping hypnosis in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Imovan in the presence of existing structural analogues. Use to treat insomnia and difficulties with falling asleep in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Imovan - hypnotics from the group of cyclopyrrolones. It has the following pharmacological properties: hypnotic, sedative, tranquilizing, anticonvulsant and muscle relaxant. These effects are associated with its effect on CNS receptors related to the macromolecular complex GABA, modulating the opening of channels for chloride ions.

Zopiclone (the active substance of Imovan) has the property of reducing the time to sleep and the frequency of nocturnal awakenings, increasing the duration of sleep and improving the quality of sleep and awakening.

Adapting to the hypnotic effect of the drug is absent for a long period of treatment, up to 17 weeks.

Composition

Zopiclone + auxiliary substances.

Pharmacokinetics

Imovan is rapidly absorbed. Absorption of the drug does not depend on sex, nor on food intake. The connection with plasma proteins is approximately 45%. After repeated administration of cumulation Zopiclone and its metabolites do not occur. Individual differences are insignificant. The main metabolites are the N-oxide derivative (pharmacologically active) and N-desmethyl metabolite (pharmacologically inactive).In the urine, zopiclone is excreted (approximately 80%), mainly in the form of metabolites, with a caloric mass of about 16%.

In elderly patients, despite a slight decrease in the metabolism in the liver and an elongation of the half-life to about 7 hours, no cumulation of the drug in the plasma was detected even after repeated administration.

Indications

treatment of transient, situational and chronic insomnia in adults (including difficulties with falling asleep, night and early awakenings).

Forms of release

Tablets coated with 7.5 mg.

Instructions for use and effective dose

Treatment should be conducted as short as possible and not more than 4 weeks. An extension of the treatment period is possible after a reassessment of the patient's condition. The drug is taken before bedtime.

Duration of treatment of transient insomnia - from 2 to 5 days, situational insomnia - from 2 to 3 weeks. In chronic insomnia, the duration of the course treatment the doctor determines individually.

The recommended adult dose is 7.5 mg. Do not exceed the indicated dose.

Treatment of elderly patients, patients with impaired liver function or with chronic pulmonary insufficiency begin with a dose of 3.75 mg and, if necessary, increase it to 7.5 mg.

In patients with renal insufficiency, it is recommended to begin treatment with a dose of 3.75 mg, despite the fact that in this pathology cumulation of zopiclone and its metabolites is not detected.

Side effect

bitter taste in the mouth;
dizziness;
headache;
residual drowsiness after waking up;
possible anterograde amnesia;
nightmarish dreams;
irritability;
confusion;
hallucinations;
aggressiveness;
confusion of consciousness;
depressed mood;
violation of coordination of movements;
depressive state;
inadequate behavior with possible development of amnesia;
dyspepsia;
nausea;
dry mouth;
itching;
rash;
angioedema;
anaphylactic reactions;
withdrawal syndrome, which manifests itself in various symptoms, such as ricochet insomnia, anxiety, tremor, excessive sweating, agitation, confusion, headache, tremor, tachycardia, delirium, nightmares, hallucinations, irritability;
seizures.

Contraindications

severe myasthenia gravis;
severe respiratory failure;
severe hepatic impairment;
sleep apnea syndrome;
age to 18 years;
hypersensitivity to the components of the drug.

Application in pregnancy and lactation

It is not recommended to use Imovan during pregnancy and lactation (breastfeeding).

Use in children

Contraindicated in children and adolescents under the age of 18 years.

Application in elderly patients

Treatment of elderly patients begins with a dose of 3.75 mg and, if necessary, increases it to 7.5 mg.

special instructions

When prescribing Imovan, it should be remembered that although the risk is minimal, it is impossible to completely exclude the development of addiction to zopiclone and its abuse. The risk of dependence or abuse arises in cases of dose disruption and duration of treatment; abuse of alcohol and / or medicines; reception with alcohol or other psychotropic drugs.

The risk of developing ricochet insomnia and withdrawal syndrome after a sharp discontinuation of zopiclone intake can not be ruled out, especially after long-term treatment. Therefore, it is recommended to gradually reduce the dose of Imovan and notify the patient about it.

Possible development of anterograde amnesia, especially with interruption of sleep or after a considerable time between taking the drug and going to sleep.To reduce the risk of manifestation of anterograde amnesia, it is necessary to take the pill just before bedtime; ensure a sleep duration of at least 6 hours.

The drug is not indicated for the treatment of depression and can even mask its symptoms.

It is released by prescription.

Impact on the ability to drive vehicles and manage mechanisms

Because of its pharmacological properties, zopiclone can degrade the ability to drive vehicles and work with mechanisms, so during the treatment period the patient should refrain from such activities.

Drug Interactions

It is not recommended simultaneous reception with alcohol, tk. it is possible to enhance the sedative effect of zopiclone.

Strengthening the oppressive effect on the central nervous system is possible with the simultaneous administration of Imovan with neuroleptics, hypnotics, tranquilizers, sedatives, antidepressants, opioid analgesics, antiepileptic drugs, anesthetics, antihistamines with sedative effect, and erythromycin.

Taking Imovan reduces the concentration of trimipramine in the plasma and its effect.

With the simultaneous administration of Imovan with inhibitors of the isoenzyme CYP3A4 (erythromycin, clarithromycin, ketoconazole, ritonavir), an increase in zopiclone concentration in plasma is possible.

With the simultaneous administration of Imovan with inducers of the isoenzyme CYP3A4 (including rifampicin, carbamazepine, phenobarbital, phenytoin), a decrease in zopiclone concentration in plasma is possible.

Analogues of the medicinal product Imovan

Structural analogs for the active substance:

Zopiclone;
Piklodorm;
Relaxon;
Somnol;
Thorson.

Analogues for the pharmacological group (hypnotics):

Andante;
Berlidorm 5;
Bromizoval;
Heminearrin;
Hypnogen;
Donormil;
Dormikum;
Zaleplon;
Zolpidem;
Zolsana;
Iwadal;
Melaxen;
Melarena;
Melatonin;
Nitrazadone;
Nitrazepam;
Nitram;
Nitrust;
Nitrosan;
Onyria;
Radedorm 5;
Reladorm;
The Raslip;
Rohypnol;
Sanvall;
Signopam;
Snovitel;
Phenobarbital;
Flormidal;
Circadian;
Estazolam;
Eunotin.

If there are no analogues of the medication for the active substance, you can go to the links below for diseases, from which the corresponding drug helps, and to look at the available analogs for therapeutic effects.

Used for the treatment of diseases: insomnia, sleep disturbance