Divina - instructions for use, analogs, reviews and release forms (tablets in the kit) for the treatment of osteoporosis and menopause or menopause symptoms in women, including use in pregnancy and lactation. Composition

In this article, you can read the instructions for using the drug Divina. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Divina in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Divina in the presence of existing structural analogs. Use for the treatment of osteoporosis and the symptoms of menopause or menopause in women,including use in pregnancy and lactation. Composition of the hormonal drug.

Divina - a combined hormone replacement preparation with natural estrogen - estradiol valerate and a natural Progesterone derivative - medroxyprogesterone acetate.

The introduction of a combination of estradiol valerate / medroxyprogesterone acetate closely mimics the natural cycle of hormonal activity characteristic of the normal menstrual cycle, i.e. The estrogen phase precedes the combined estrogen / progestagen phase, followed by menstrual bleeding occurring within 1 week after the last administration of the drug.

After 12 months of Divina's use, hot flushes and sweating increase at night.

In women in the climacteric period, against the background of Divina's intake, the mineral content and density of bone tissue do not decrease, i.e. prevents the development of osteoporosis.

The drug has a beneficial effect on lipid levels in the blood: reduces the level of lipoproteins of low density and cholesterol, reduces the risk of atherosclerosis; increases the level of high-density lipoproteins,which have an anti-atherogenic effect.

The use of divina prevents the development of hyperplasia and malignancy of the endometrium.

Composition

Estradiol valerate + Medroxyprogesterone acetate + excipients.

Pharmacokinetics

Estradiol valerate

When taking the drug inside the estradiol valerate is well absorbed from the digestive tract. Estradiol valerate is biotransformed mainly in the liver with the formation of a less active estriol. Metabolites of estradiol are excreted from the body with urine in the form of water-soluble compounds with glucuronic and sulfuric acids.

Medroxyprogesterone acetate

When you take 1 tablet Divina inside medroksiprogesterona acetate is well absorbed from the digestive tract. Medroxyprogesterone practically does not bind to plasma proteins. Medroxyprogesterone is excreted in the form of metabolites with urine and bile.

Indications

• relief of symptoms resulting from deficiency of estrogen and progesterone in menopausal women (hot flashes, night sweats and other symptoms);
• prevention of osteoporosis in postmenopausal women.

Forms of release

Tablets of two types: 21 pcs.in blister with the calendar scale, including: white tablets 2 mg: 11 pieces; tablets of blue color 2 mg + 10 mg: 10 pieces.

Instructions for use and reception scheme

Inside, 1 tablet per day (preferably in the evening) for 21 days, followed by a 7-day break, during which bleeding occurs menstrualnopodobnoe, and then again begin taking the tablets (see markings on the packaging with calendar scale).

During the first 11 days, pills containing only estrogen (white) are taken.

Then for the remaining 10 days - tablets containing a combination of estrogen with progesterone (blue).

Tablets can be taken at any time if the normal menstrual cycle has stopped or if it is irregular, and also on the 5th day of menstruation.

If you miss a pill, you should take it no later than 12 hours and then take the drug in the usual way.

Side effect

• violation of the regularity of bleeding (metrorrhagia);
• engorgement of mammary glands;
• headache;
• increased fatigue;
• nausea;
• a feeling of heaviness in the lower limbs.

Contraindications

• thromboembolic disorders or pathology of cerebral vessels in the anamnesis (including in the family);
• sickle-cell anemia;
• tumors of the pituitary gland;
• estrogen-dependent tumors (breast cancer, uterus);
• acute and chronic liver disease;
• endometriosis;
• arterial hypertension, resistant to therapy;
• pregnancy.

Application in pregnancy and lactation

Divina is contraindicated in pregnancy.

The drug can not be used as a contraceptive.

Use in children

Children are not used.

special instructions

In the climacteric period, differences in the duration of the menstrual cycle are possible, so some women may begin bleeding while taking blue tablets of Divin's drug. In these cases, it is necessary to temporarily stop taking the drug, and after the end of the bleeding, resume taking white tablets.

Impact on the ability to drive vehicles and manage mechanisms

Divina does not affect the ability to drive a car and engage in other activities that require increased attention and speed of psychomotor reactions.

Drug Interactions

With the simultaneous use of divin may reduce the effectiveness of antihypertensive drugs, oral anticoagulants and oral hypoglycemic drugs.

Barbiturates, anticonvulsants, tetracyclines and rifampicin reduce the Divina effect when applied simultaneously.

Analogues of the drug Divina

Structural analogs for the active substance:

• Divertrain;
• The individual.

Analogues on the curative effect (remedies for the elimination of menopausal and climacteric disorders):

• Alliter;
• Bellaspon;
• Gel for normalization of vaginal microflora "Floragin Gel";
• Gynodian Depot;
• Grandaxin;
• Deprim;
• Deprim forte;
• Diazepec;
• The Divigel;
• Duphaston;
• Inoklim;
• Ipronal;
• Climadinone;
• Climadinon Uno;
• Climaxan is homeopathic;
• Climakt Hel;
• Climacoplane;
• Klimalanin;
• Climara;
• Klimen;
• Klimodien;
• Cliogest;
• Krajonon;
• Menopace;
• Metovit;
• Miakaltsik;
• Microfolline;
• The Nervochel;
• Noblessite;
• Novo Passit;
• Ovariamine;
• Ovestin;
• Pausogest;
• Premarin;
• Proginova;
• Revmelid;
• Relanium;
• Remens;
• Sagenite;
• Sinestrol;
• Teletext;
• Triaclim;
• Femoston;
• Phlogenzyme;
• Chloroproticsen;
• Cyclime;
• Cyclo Proginova;
• Estimax;
• Estroel;
• Estrogele;
• Estrofem;
• Ethinyl estradiol.

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