Andriol - instructions for use, reviews, analogs and forms of release (capsules or tablets 40 mg) of a drug based on testosterone for the treatment of infertility and hormone therapy in men. Composition

In this article, you can read the instructions for using the drug Andriol. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Andriol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Andriol in the presence of existing structural analogues. Use to treat infertility and hormone therapy in men. Composition of the hormonal drug.

Andriol is a hormonal drug, contains testosterone in its composition. Testosterone is an endogenous hormone necessary for the normal development of male genital organs and secondary sexual characteristics, to maintain normal function of the testicles, the prostate and seminal vesicles, maintaining libido and potency. The use of the drug for the treatment of hypogonadism in men leads to a clinically significant increase in the concentration in the plasma of testosterone, dihydrotestosterone and androstenedione and a decrease in globulin binding sex hormones (SHGG). In men with primary (hypergonadotropic) hypogonadism, the use of the drug leads to a normalization of the gonadotropin concentration.

Composition

Testosterone undecanoate + excipients.

Pharmacokinetics

After ingestion, a significant portion of Andriol along with the lipophilic solvent is absorbed into the small intestine and enters the lymphatic system, thus avoiding the primary passage through the liver. With the absorption of testosterone, undecanoate is partially reduced to form the dihydrotestosterone undecanoate. From the lymphatic system, he enters the plasma.In the plasma and tissues, as a result of the hydrolysis of testosterone undecanoate and diddrotestosterone undecanoate, the natural male sex hormones testosterone and dihydrotestosterone are released.

A single dose of 80-160 mg of Andriol leads to a clinically significant increase in the total plasma concentration of testosterone, Cmax is approximately 40 nmol / L and is achieved 4-5 hours after administration. The increased concentration of testosterone is retained, but at least within 8 hours. It is excreted mainly with urine in the form of conjugates (etiocholanolone and androsterone).

Indications

Hormone replacement therapy for violations associated with testosterone deficiency:

• post-stroke syndrome;
• eunuchoidism;
• hypopituitarism;
• endocrine impotence;
• Some forms of infertility associated with impaired spermatogenesis;
• menopausal symptoms in men, such as decreased libido and physical activity, deterioration in overall well-being;
• masculinization in transsexuals;
• osteoporosis in men, caused by a deficiency of androgens.

Forms of release

Capsules 40 mg (sometimes mistakenly called pills).

Instructions for use and dosage

The dose is selected individually depending on the clinical effect.

As a rule, the initial dose is 120-160 mg per day for 2-3 weeks, maintaining a dose of 40-120 mg per day.

The drug should be taken with food, washed down with a small amount of water. Capsules should be swallowed whole, not liquid. It is advisable to take half the dose in the morning, and the second half in the evening. If an uneven number of capsules is taken, a higher dose should be taken in the morning.

Side effect

In boys in the prepubertal period:

• premature puberty;
• premature closure of bone growth zones;
• increased frequency of erections and an increase in the size of the penis.

In men:

• priapism;
• increased sexual arousal;
• oligospermia;
• decrease in ejaculate volume.

In all patients:

• sodium and water retention.

Contraindications

• hypersensitivity to any components of the drug;
• verified or suspected carcinoma of the prostate or breast;
• pregnancy and lactation.

Application in pregnancy and lactation

Contraindicated in pregnancy and lactation.

Use in children

It is used with caution in boys in the prepubertal period in order to avoid premature closure of the epiphyses and accelerated puberty.

special instructions

With caution: in boys in the prepubertal period in order to avoid premature closure of the epiphyses and accelerated puberty; latent or severe heart failure, renal dysfunction, arterial hypertension, epilepsy, migraine (currently or in anamnesis); benign prostatic hypertrophy.

At the household level, Andriol is used in bodybuilding and professional sports for building muscle mass after training. It is worth noting the negative side effects when using drugs in an unusual dosage and purpose.

In case of androgen-dependent side effects, treatment should be discontinued. After their disappearance it is necessary to resume treatment with lower doses. The use of the drug may affect the results of some laboratory tests.

Drug Interactions

With the simultaneous use with inductors of enzymes of microsomal oxidation (barbiturates,rifampicin) may reduce the effectiveness of the drug.

Analogues of the drug Andriol

Structural analogs for the active substance:

• Andriol TC;
• Androgel;
• Nebido;
• Testosterone propionate.

Analogues for the pharmacological group (androgens and antiandrogens):

• Avodart;
• Alfinal;
• Anandron;
• Androblok;
• Androgel;
• Androkur;
• Androkur Depot;
• Balutar;
• Bellune 35;
• Bicalutamide;
• Bicutuler;
• Bicane;
• Bikaprost;
• Bilumide;
• Diane 35;
• Grain;
• Casodex;
• Methyltestosterone;
• Nebido;
• Nemestran;
• Omnadren;
• Penester;
• Proviron;
• Proscar;
• Prosteride;
• Sustanon 250;
• Test for injection 10%;
• Urofin;
• Finast;
• Finasteride;
• Finpros;
• Flutakan;
• Flutamide;
• Flutaplex;
• Chloe;
• Cyproterone Teva;
• Erica 35.

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