Ampioks - instructions for use, reviews, analogs and forms of release (capsules or tablets 250 mg, injections in ampoules for injection in sodium solution) antibiotic for the treatment of angina, sinusitis and bronchitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Ampiox. Comments from visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Ampiox in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ampiox for the presence of existing structural analogs.Use for the treatment of angina, sinusitis, bronchitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition of antibiotic.

Ampiox - Combined antibiotic, combining the spectrum of action of ampicillin and oxacillin.

Ampicillin - semi-synthetic penicillin, acts bactericidal, acid-fast. It is active against Gram-positive, non-penicillinase (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae), and Gram-negative (Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Salmonella spp. (Salmonella), Shigella spp. (Shigella), Proteus mirabilis (proteus), Haemophilus influenzae) of microorganisms.

Oxacillin is a penicillin-resistant semisynthetic antibiotic from the penicillin group, acid-fast; has bactericidal action against gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae, Actinimyces spp., Bacillus anthracis, Corynebacterium diphtheriae, anaerobic spore-forming rods, including Clostridium), Gram-negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis), Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Klebsiella pneumoniae (Klebsiella), Actinomyces spp., Treponema spp.

Pseudomonas aeruginosa and other non-fermenting gram-negative bacteria are resistant to the action of the combination, most strains of Proteus vulgaris, Providencia rettgeri, Morganella morganii.

Composition

Oxacillin (in the form of the sodium salt) + Ampicillin (in the form of trihydrate) + auxiliary substances (capsules).

Oxacillin sodium + Ampicillin sodium + excipients (ampoules).

Pharmacokinetics

When intravenously introduced into the blood, drug concentrations are rapidly created that exceed those of intramuscular injection.

Both antibiotics are excreted by the kidneys, in part - with bile. When repeated injections are not cumulated.

Indications

Bacterial infections caused by susceptible pathogens:

• sinusitis;
• tonsillitis;
• otitis media;
• bronchitis;
• pneumonia;
• cholangitis;
• cholecystitis;
• pyelonephritis;
• pyelitis;
• cystitis;
• urethritis;
• gonorrhea;
• cervicitis;
• infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, etc.).

Prevention of postoperative complications during surgical interventions (including against the background of immunodeficiency), infections in newborns (infection of the amniotic fluid, impaired breathing of the newborn, requiring the use of resuscitative measures, the risk of aspiration pneumonia).

Severely leaking infections:

• sepsis;
• endocarditis;
• meningitis;
• postpartum infection.

Forms of release

Capsules 250 mg (sometimes mistakenly called pills).

Powder for the preparation of solution for intramuscular and intravenous injection Ampiox Sodium (injections in ampoules for injection).

Instructions for use and dosage

Capsules

Inside, a single dose for adults and children over 14 years is 0.5-1 g, daily - 2-4 g. Children 3-7 years - 100 mg / kg per day, 7-14 years - 50 mg / kg per day. Duration of treatment - from 5-7 days to 2 weeks. The daily dose is divided into 4-6 receptions.

Ampoules

Intramuscularly and intravenously (struyno, drip), the daily dose for adults and children over 14 years old is 3-6 g; for newborns, prematurity and children under 1 year - 100-200 mg / kg per day; 1-6 years - 100 mg / kg per day; 7-14 years - 100 mg / kg per day. The daily dose is administered in 3-4 doses, with an interval of 6-8 hours. If necessary, these doses can be increased by 1.5-2 times.

For the / m introduction, the contents of the vial (0.2 and 0.5 g) are dissolved respectively into 2 and 5 ml of water for injection.

For intravenous administration (within 2-3 minutes), a single dose is dissolved in 10-15 ml of water for injection or 0.9% NaCl solution.

For intravenous administration of adults, a single dose is dissolved in 100-200 ml of 0.9% NaCl solution or 5% Dextrose solution and injected at a rate of 60-80 cap / min; Children as a solvent use 30-100 ml of a 5-10% solution of dextrose. In / in the drug administered 5-7 days, followed by a transition to the / m or oral reception.

The solutions are used immediately after preparation.

Side effect

• hives;
• hyperemia of the skin;
• angioedema;
• rhinitis;
• conjunctivitis;
• fever;
• arthralgia;
• eosinophilia;
• anaphylactic shock;
• superinfection;
• dysbiosis;
• change in taste;
• vomiting, nausea;
• diarrhea;
• pseudomembranous enterocolitis;
• leukopenia, neutropenia, anemia;
• at the site of infiltration, soreness.

Contraindications

• hypersensitivity;
• Infectious mononucleosis;
• lymphocytic leukemia.

Application in pregnancy and lactation

Possible use of Ampioxa during pregnancy according to the indications.

It is excreted in breast milk in low concentrations. If you need to use the drug during lactation, you should decide whether to stop breastfeeding.

Use in children

Use with caution in children born to mothers with hypersensitivity to penicillins. Apply on indications.

special instructions

In course treatment it is necessary to monitor the status of the functions of the organs of hematopoiesis, liver and kidneys.

The possibility of developing superinfection (due to the growth of insensitive microflora) requires a corresponding change in antibacterial therapy.

In patients who are hypersensitive to penicillins, there may be cross-allergic reactions with cephalosporin antibiotics.

When used in high doses in patients with renal insufficiency, the toxic effect of Ampiox on the CNS is possible.

Drug Interactions

Antacids, glucosamine, laxatives, food, aminoglycosides (for enteral administration) slow down and decrease absorption; Ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; bacteriostatic medicinal products (macrolides, chloramphenicol, lincosamines, tetracyclines, sulfonamides) - antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism which forms PABC, ethinyl estradiol - the risk of bleeding "breakthrough".

Diuretics, allopurinol, tubular secretion blockers, phenylbutazone, non-steroidal anti-inflammatory drugs (NSAIDs), and other drugs that block tubular secretion, increase the concentration of the drug in the plasma, which increases the risk of developing toxic effects.

Allopurinol increases the risk of skin rash.

Analogues of the drug Ampiox

Structural analogs for the active substance:

• Ampiox sodium;
• Oxamp;
• Oxamp sodium;
• Oxampicin;
• Oksamsar.

Analogues on the curative effect (antibiotics for the treatment of bacterial pneumonia):

• Avelox;
• Azitral;
• AzitRus forte;
• Amoxisar;
• Ammisid;
• Glevo;
• Carbenicillin disodium salt;
• Clamosar;
• Oxamp;
• Ospen;
• Sumazid;
• Urophosfabol;
• Flemoclav Solutab;
• Fromromide;
• Fusidine sodium;
• Edicyin.

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