Xizal - instructions for use, analogs, reviews and release forms (drops, tablets 5 mg) drugs for the treatment of rhinitis, urticaria and other manifestations of allergies in adults, children and pregnancy. Composition and interaction with alcohol

In this article, you can read the instructions for using the drug Xizal. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Xyzal in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Xizal in the presence of existing structural analogues. Use for the treatment of rhinitis, conjunctivitis, urticaria and other manifestations of allergy in adults, children, as well as during pregnancy and lactation.Composition and interaction of the drug with alcohol.

Xizal - blocker of histamine H1 receptors, Cetirizine enantiomer, belongs to the group of competitive antagonists of histamine. The affinity for histamine H1 receptors in levocetirizine (Xisal active ingredient) is 2 times higher than that of cetirizine.

Xizal influences the histamine-dependent stage of allergic reactions, and also reduces the migration of eosinophils, reduces vascular permeability, and limits the release of inflammatory mediators. Prevents development and facilitates the course of allergic reactions, has antiexudative, antipruritic effect, practically does not have anticholinergic and antiserotonin action. In therapeutic doses, it practically does not have a sedative effect.

Composition

Levocetirizine dihydrochloride + excipients.

Pharmacokinetics

Pharmacokinetic parameters of levocetirizine vary linearly and practically do not differ from the pharmacokinetics of cetirizine. After ingestion, levocetirizine is rapidly absorbed from the digestive tract. The intake of food does not affect the degree of absorption, although its rate decreases. Bioavailability is 100%.The binding of levocetirizine to plasma proteins is 90%. Less than 14% is metabolized in the liver by N- and O-dealkylation (unlike other histamine H1 receptor blockers that are metabolized in the liver with the participation of cytochrome P450 isoenzymes) to form a pharmacologically inactive metabolite. Because of the low level of metabolism and the lack of a metabolic potential, the interaction of levocetirizine with other drugs is unlikely. About 85.4% of the dose is excreted by the kidneys unchanged by glomerular filtration and tubular secretion; about 12.9% is excreted through the intestine.

Indications

Symptomatic therapy of allergic diseases and conditions:

year-round (persistent) and seasonal (intermittent) allergic rhinitis and allergic conjunctivitis (itching, sneezing, rhinorrhea, lacrimation, congestion hyperemia, nasal congestion);
Pollinosis (hay fever);
urticaria (including chronic idiopathic urticaria);
angioedema;
other allergic dermatoses, accompanied by itching and rashes.

Forms of release

The tablets covered with a cover of 5 mg.

Drops for oral administration.

Instructions for use and dosing regimen

The drug is administered orally during meals or on an empty stomach.

Tablets are taken with a small amount of water, without chewing.

Drops for ingestion are taken with a teaspoon. If necessary, the dose of the drug can be diluted in a small amount of water immediately before use.

Adults and children over 6 years of age: daily dose of 5 mg (1 tablet or 20 drops).

Children aged 2 to 6 years: 1.25 mg (5 drops) 2 times a day; daily dose of 2.5 mg (10 drops).

Side effect

headache;
fatigue;
drowsiness;
asthenia;
aggression;
excitation;
convulsions;
hallucinations;
depression;
impaired vision;
tachycardia;
dyspnea;
dry mouth;
abdominal pain;
nausea;
diarrhea;
hepatitis;
myalgia;
increase in body weight;
itching;
rash;
hives;
angioedema;
anaphylaxis.

Contraindications

terminal stage of renal failure (QC less than 10 ml / min);
children under 6 years (for tablets);
children under 2 years of age (for drops for oral administration);
pregnancy;
increased sensitivity to the components of the drug, especially in patients with galactosemia or severe intolerance to lactose (for tablets);
hypersensitivity to levocetirizine or piperazine derivatives.

Application in pregnancy and lactation

Adequate and strictly controlled clinical trials on the safety of use of the drug in pregnant women have not been conducted, therefore Xyzal should not be administered during pregnancy.

Levocetirizine excreted in breast milk, so if you need to use the drug during lactation, breastfeeding for the duration of admission should be discontinued.

In experimental animal studies, there were no direct or indirect adverse effects of levocetirizine on the developing fetus (including in the postnatal period), the course of pregnancy and childbirth also did not change.

Use in children

Contraindicated in children under 6 years (for tablets); in children under 2 years (for drops for oral administration).

Children older than 6 years: daily dose of 5 mg (1 tablet or 20 drops).

Children aged 2 to 6 years: 1.25 mg (5 drops) 2 times a day; daily dose of 2.5 mg (10 drops).

Application in elderly patients

Since Xisal is excreted by the kidneys, when the drug is prescribed for elderly patients, the dose should be adjusted depending on the magnitude of the CC.

special instructions

The patient should be careful when taking the drug and drinking alcohol at the same time.

Impact on the ability to drive vehicles and manage mechanisms

At an objective estimation of ability to driving of motor transport and work with mechanisms it is authentic not revealed any undesirable phenomena at purpose or appointment of a preparation in the recommended dose. Nevertheless, during the treatment period, it is advisable to refrain from engaging in potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

The interaction of levocetirizine with other drugs has not been studied.

When studying the drug interaction of the racemate cetirizine with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, glipizide and diazepam, no clinically significant undesirable interaction was detected.

With simultaneous application with theophylline (400 mg per day), the total clearance of cetirizine is reduced by 16%, the pharmacokinetic parameters of theophylline do not change.

In a number of cases with the simultaneous use of Xyzal with ethanol (alcohol) or drugs,which have a depressing effect on the central nervous system, it is possible to enhance their effect on the central nervous system, although it has been shown that the racemate of cetirizine potentiates the effect of alcohol.

Xizal analogues of the drug

Structural analogs for the active substance:

Glencet;
Zenaro;
Zodak Express;
Levocetirizine;
Suprastinex;
Cezer;
Eltset.

Analogues on the curative effect (means for the treatment of pollinosis):

Allergies;
Benarin;
Vibroloor;
Vibrocil;
Delufen;
Zincet;
Zirtek;
Zodak;
Zodak Express;
Kestin;
Ketotifen;
Claridol;
Lethisen;
Lotharen;
Nazarel;
Peritol;
Pipolphen;
Primalan;
Ruzam;
Singulex;
Suprastin;
Suprastinex;
Tavegil;
Telfast;
Fexadine;
Fenkarol;
Cetrin;
Erius;
Erolin.

If there are no analogues of the medication for the active substance, you can go to the links below for diseases, from which the corresponding drug helps, and to look at the available analogs for therapeutic effects.

Used for the treatment of diseases: allergy, dermatosis, runny nose, pollinosis, conjunctivitis, pruritus, allergic rhinitis, hives, allergic conjunctivitis, hay fever, angioedema, allergic dermatosis, contact dermatitis, chronic lichen, angioedema