Ibuprofen - instructions for use, reviews, analogs and formulations (tablets 200 mg and 400 mg, suppositories 60 mg, gel and ointment 5%, syrup) for the treatment of inflammation and heat in adults, children and pregnancy
In this article, you can read the instructions for using the drug Ibuprofen. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ibuprofen in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ibuprofen in the presence of existing structural analogues. Use to treat inflammation and relieve heat, as well as analgesia in adults, children, as well as during pregnancy and lactation.
Ibuprofen - Non-steroidal anti-inflammatory agent, phenylpropionic acid derivative. Has anti-inflammatory, analgesic and antipyretic effect.
The mechanism of action is associated with oppression of the activity of COX, the main enzyme of arachidonic acid metabolism, which is the precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due both to peripheral (indirectly, through suppression of prostaglandin synthesis) and to the central mechanism (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Suppresses the aggregation of platelets.
With external application has anti-inflammatory and analgesic effect. Reduces the morning stiffness, promotes an increase in the volume of movements in the joints.
Pharmacokinetics
When ingestion ibuprofen is almost completely absorbed from the digestive tract. Simultaneous food intake slows down the rate of absorption. Metabolised in the liver (90%). 80% of the dose is excreted in the urine mainly in the form of metabolites (70%), 10% - unchanged; 20% is excreted through the intestines in the form of metabolites.
Indications
- inflammatory diseases of the joints and spine (including rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, gouty arthritis);
- moderate pain syndrome of various etiologies (including headache, migraine, toothache, neuralgia, myalgia, postoperative pain, posttraumatic pain, primary algodismenorea);
- febrile syndrome with "colds" and infectious diseases;
- is intended for symptomatic therapy, reducing pain and inflammation at the time of use, the progression of the disease is not affected.
Forms of release
Tablets coated with 200 mg and 400 mg.
Candles for rectal use for children 60 mg.
Gel for external use 5%.
Ointment for external use 5%.
Syrup or suspension for oral administration.
Tablets effervescent Ibuprofen - Hemofarm.
Instructions for use and dosage
Ibuprofen is prescribed for adults and children over 12 years inside, in tablets of 200 mg 3-4 times a day. To achieve a rapid therapeutic effect, the dose can be increased to 400 mg (2 tablets) 3 times a day. When the therapeutic effect is achieved, the daily dose of the drug is reduced to 600-800 mg.Take the morning dose before meals, drinking with a sufficient amount of water (for a faster absorption of the drug). The remaining doses are taken throughout the day after meals.
The maximum daily dose is 1200 mg (do not take more than 6 tablets in 24 hours). Repeated dose should not be taken more than 4 hours. The duration of the drug use without consulting a doctor is no more than 5 days.
Do not use in children younger than 12 years old without consulting a doctor.
Children from 6 to 12 years: 1 tablet no more than 4 times a day; the drug can be used only in the case of a child's body weight of more than 20 kg. The interval between taking the tablets is not less than 6 hours (the daily dose is not more than 30 mg / kg).
Apply externally for 2-3 weeks.
The maximum daily intake for adults with oral or rectal administration is 2.4 g.
Side effect
- NSAIDs-gastropathy (abdominal pain, nausea, vomiting, heartburn, decreased appetite, diarrhea, flatulence, constipation, rarely - ulceration of the gastrointestinal mucosa, which in some cases is complicated by perforation and bleeding);
- irritation or dryness of the oral mucosa;
- pain in the mouth;
- ulceration of the mucosa;
- dyspnea;
- bronchospasm;
- Hearing impairment: hearing loss, ringing or tinnitus;
- visual impairment: toxic damage to the optic nerve, blurred vision or double vision
- dryness and irritation of the eyes;
- edema of the conjunctiva and eyelids (allergic genesis);
- headache;
- dizziness;
- insomnia;
- anxiety;
- nervousness and irritability;
- psychomotor agitation;
- drowsiness;
- depression;
- confusion of consciousness;
- hallucinations;
- heart failure;
- tachycardia;
- increased blood pressure;
- allergic nephritis;
- skin rash (usually erythematous or urticaria);
- itching;
- angioedema;
- anaphylactoid reactions;
- anaphylactic shock;
- fever;
- allergic rhinitis;
- anemia (including hemolytic, aplastic);
- thrombocytopenia and thrombocytopenic purpura;
- agranulocytosis;
- leukopenia;
- increased sweating.
Laboratory indicators:
- bleeding time (may increase);
- serum glucose concentration (may decrease);
- clearance of creatinine (may decrease);
- hematocrit or hemoglobin (may decrease);
- serum creatinine concentration (may increase);
- activity of "liver" transaminases (may increase).
Contraindications
- hypersensitivity to any of the ingredients that make up the drug. Hypersensitivity to acetylsalicylic acid or other NSAIDs, incl. anamnestic data on an attack of bronchial obstruction, rhinitis, hives after taking acetylsalicylic acid or other NSAIDs; complete or incomplete syndrome of acetylsalicylic acid intolerance (rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
- erosive and ulcerative diseases of the organs of the gastrointestinal tract in the stage of exacerbation (including peptic ulcer of the stomach and duodenum, Crohn's disease, ulcerative colitis);
- inflammatory bowel disease;
- hemophilia and other disorders of blood clotting (including hypocoagulation), hemorrhagic diathesis;
- period after aortocoronary shunting;
- gastrointestinal bleeding and intracranial hemorrhage;
- severe hepatic impairment or active liver disease;
- progressive kidney disease;
- marked renal failure with creatinine clearance less than 30 ml / min, confirmed hyperkalemia;
- pregnancy;
- children's age till 6 years.
Application in pregnancy and lactation
Contraindicated in pregnancy. Apply with caution in the lactation period.
special instructions
The drug should be treated at the lowest effective dose, the minimum possible short course. During long-term treatment, control of the peripheral blood picture and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, careful monitoring including esophagogastroduodenoscopy, a general blood test (determination of hemoglobin), and analysis of feces for latent blood are shown.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test.
Patients should refrain from all activities requiring increased attention, rapid mental and motor reaction. During the period of treatment, ethanol (alcohol) is not recommended.
Drug Interactions
It is not recommended simultaneous reception of ibuprofen with Acetylsalicylic acid and other NSAIDs. With the simultaneous administration of ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (possibly increasing the incidence of acute coronary insufficiency in patients receiving as an antiplatelet agent a small dose of acetylsalicylic acid,after the start of taking ibuprofen). When administered with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding increases at the same time. Simultaneous reception with serotonin reuptake inhibitors (citalopram, fluoxetine, paroxetine, sertraline) increases the risk of developing serious gastrointestinal bleeding.
Cefamandol, cefaperazone, cefotetan, valproic acid, plikamycin, increase the frequency of hypoprothrombinemia. Cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects. Drugs that block tubular secretion, reduce excretion and increase the plasma concentration of ibuprofen. Inducers of microsomal oxidation (phenytoin, ethanol (alcohol), barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication.Inhibitors of microsomal oxidation - reduce the risk of hepatotoxic effects. Reduces the hypotensive activity of vasodilators, natriuretic and diuretic activity in Furosemide and hydrochlorothiazide. Reduces the effectiveness of uricosuric drugs, increases the effect of indirect anticoagulants, antiaggregants, fibrinolytics (increased risk of hemorrhagic disorders), enhances ulcerogenic effects with bleeding mineralocorticosteroids, glucocorticosteroids, colchicine, estrogens, ethanol (alcohol). Strengthens the effect of oral hypoglycemic drugs and insulin derivatives of sulfonylurea. Antacids and colestyramine reduce absorption. Increases the concentration in the blood of digoxin, lithium preparations, methotrexate. Caffeine increases the analgesic effect.
Analogues of the drug Ibuprofen
Structural analogs for the active substance:
- Advance;
- ArthroCam;
- Bonifen;
- Brufen;
- Brufen retard;
- Burana;
- Deblock;
- Children's Motrin;
- Dolgit;
- Ibuprom;
- Ibuprom Max;
- Ibuprom Sprint Caps;
- Ibuprofen Lannacher;
- Ibuprofen Nycomed;
- Ibuprofen-Verte;
- Ibuprofen-Hemofarm;
- Ibusan;
- Ibutop gel;
- Ibufen;
- Iprene;
- MIG 200;
- MIG 400;
- Nurofen;
- Nurofen for children;
- Nurofen Period;
- Nurofen UltraKap;
- Nurofen fort;
- Nurofen Express;
- Pedee;
- Solpaflex;
- Faspik.
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